Results 131 to 140 of about 2,827 (245)

Mechanism of Isonitrilase, a Nonheme Iron Decarboxylase Involved in the Biosynthesis of the Isonitrile Group in Peptides: A Computational Study

Chemistry – A European Journal, EarlyView.
A combination of molecular dynamics and quantum mechanics calculations shows that substrate is tightly bound inside the enzyme structure that enables two successive catalytic cycles with dioxygen and α‐ketoglutarate with an initial desaturation followed by hydrogen abstraction and decarboxylation steps to form an isonitrile substituent.
Chengxu Zhu, Sam P. de Visser
wiley   +1 more source

REDUCTIVE COUPLING OF METHYL ALPHA-BROMO-ALPHA-CHLOROCARBOXYLATES

, 1994
CuBr-LiOCH3 in methanol efficiently promotes the reductive coupling of methyl alpha-bromo-alpha-chlorocarboxylates to dimethyl alpha,alpha'-dichloro ...
BONI M, ZUCCHI, Claudia, PAGNONI, Ugo Maria, GHELFI, Franco   +3 more
core  

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Implementation of guideline‐recommended medical therapy for patients with heart failure in Europe

ESC Heart Failure, Volume 12, Issue 2, Page 790-798, April 2025.
Abstract Physicians' adherence to guideline‐recommended heart failure (HF) treatment remains suboptimal, especially regarding the target doses. In particular, there is evidence that non‐cardiologists are less compliant with HF guideline recommendations. This is likely to have a detrimental impact on patients' survival, readmissions and quality of life.
Maurizio Volterrani, Petar Seferovic, Gianluigi Savarese, Ilaria Spoletini, Egidio Imbalzano, Antoni Bayes‐Genis, Ewa Jankowska, Michele Senni, Marco Metra, Ovidiu Chioncel, Andrew J. S. Coats, Giuseppe M. C. Rosano   +11 more
wiley   +1 more source

Asymmetric carbolithiation of 2-phenylselenofumarate derivatives: a short synthesis of (-)-roccellaric acid

, 2000
(−)-Roccellaric acid and variously substituted succinates are obtained through direct asymmetric carbolithiation of 2-phenylselenofumarate derivatives, followed by reaction with suitable ...
MARGARITA R, PARLANTI L, ORSINI, MONICA, ORLANDO C, PIANCATELLI G.   +4 more
core  

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger, Elric Zweck, Constanze Moos, Patrick Horn, Fabian Voß, Heinz‐Peter Schultheiss, Jacob Eifer Møller, Udo Boeken, Hug Aubin, Artur Lichtenberg, Malte Kelm, Michael Roden, Amin Polzin, Ralf Westenfeld, Julia Szendroedi, Daniel Scheiber   +15 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Dimethyl fumarate as a versatile therapeutic agent: molecular mechanisms and potential clinical applications. [PDF]

Mol Biol Rep
Zingkou E, Medoro A, Davinelli S, Saso L, Sotiropoulou G, Pampalakis G.   +5 more
europepmc   +1 more source

Succinates via asymmetric conjugate additions

, 1998
Available from British Library Document Supply Centre-DSC:D201324 / BLDSC - British Library Document Supply CentreSIGLEGBUnited ...
Todd, R.S.
core  

First-trimester urinary glycolic acid and methylsuccinic acid measurement for preeclampsia prediction: A Systematic review protocol. [PDF]

PLoS One
Chagonda S, Kodogo V, Katambarare F, Mawira R, Marume M, Manasa J, Tanyanyiwa D, Matenga J.   +7 more
europepmc   +1 more source