Results 21 to 30 of about 29,384 (211)

Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography

IUCrJ, 2021
Here, we illustrate what happens inside the catalytic cleft of an enzyme when substrate or ligand binds on single-millisecond timescales. The initial phase of the enzymatic cycle is observed with near-atomic resolution using the most advanced X-ray ...
Suraj Pandey, George Calvey, Andrea M. Katz, Tek Narsingh Malla, Faisal H. M. Koua, Jose M. Martin-Garcia, Ishwor Poudyal, Jay-How Yang, Mohammad Vakili, Oleksandr Yefanov, Kara A. Zielinski, Sasa Bajt, Salah Awel, Katarina Doerner, Matthias Frank, Luca Gelisio, Rebecca Jernigan, Henry Kirkwood, Marco Kloos, Jayanath Koliyadu, Valerio Mariani, Mitchell D. Miller, Grant Mills, Garrett Nelson, Jose L. Olmos Jr, Alireza Sadri, Tokushi Sato, Alexandra Tolstikova, Weijun Xu, Abbas Ourmazd, John C. H. Spence, Peter Schwander, Anton Barty, Henry N. Chapman, Petra Fromme, Adrian P. Mancuso, George N. Phillips Jr, Richard Bean, Lois Pollack, Marius Schmidt   +39 more
doaj   +1 more source

Antibiofilm Activity of β-Lactam/β-Lactamase Inhibitor Combination against Multidrug-Resistant Salmonella Typhimurium

Pathogens, 2022
This study was designed to assess the effect of β-lactam/β-lactamase inhibitor combinations on the inhibition of biofilm formation of Salmonella Typhimurium.
Nana Nguefang Laure, Juhee Ahn
doaj   +1 more source

In vitro synergism of combinations of colistin with selected antibiotics against colistin-resistant Acinetobacter baumannii

GMS Hygiene and Infection Control, 2014
[english] Aim: The in vitro activity of colistin in combination with sulbactam, netilmicin, and vancomycin against colistin-resistant strains was investigated. Furthermore, the clonal relationship of the strains was analyzed.
Percin, Duygu, Akyol, Selcan, Kalin, Gamze   +2 more
doaj   +1 more source

Sulbactam-containing β-lactamase inhibitor combinations [PDF]

, 2008
Sulbactam irreversibly inhibits the hydrolytic activity of β-lactamases. This compound is commercially available in combination with either ampicillin or cefoperazone. In each instance, the activity of the partner antibiotic against β-lactamase-producing
Sierra Valverde, Álvaro Javier, Akova, M.   +1 more
core   +1 more source

The known-unknown: third- and fourth-generation cephalosporins combined with sulbactam [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2023
Despite the presence of more than 100 different antibacterials in the therapeutic arsenal, beta-lactam antibiotics, in general, and the third-generation cephalosporins, in particular, remain the main option for the treatment of the most of infections in ...
Stetsiouk O.U., Kovalenko T.N., Andreeva I.V., Belkova Yu.A.   +3 more
doaj   +1 more source

The Potential Role of Sulbactam and Cephalosporins Plus Daptomycin Against Daptomycin-Nonsusceptible VISA and H-VISA Isolates: An In Vitro Study

Antibiotics, 2019
This study assesses the synergistic effect of the combination of cephalosporins and sulbactam with daptomycin against daptomycin-nonsusceptible, vancomycin-intermediate resistant Staphylococcus aureus (VISA) or heterogeneous vancomycin-intermediate S ...
Chih-Cheng Lai, Chi-Chung Chen, Ying-Chen Lu, Tsuey-Pin Lin, Hung-Jui Chen, Bo-An Su, Chien-Ming Chao, Yin-Ching Chuang, Hung-Jen Tang   +8 more
doaj   +1 more source

Case Report: First Case of Cefotaxime-Sulbactam-Induced Acute Intravascular Hemolysis in a Newborn With ABO Blood Type Incompatibility by the Mechanism of Non-Immunologic Protein Adsorption

Frontiers in Immunology, 2021
BackgroundABO blood type incompatibility hemolytic disease of newborn (ABO-HDN) and drug-induced immune hemolytic anemia (DIIHA) due to non-immunologic protein adsorption (NIPA) mainly cause extravascular hemolysis.
Yuanjun Wu, Yong Wu, Yong Yang, Baochan Chen, Jianqun Li, Ganping Guo, Fu Xiong, Fu Xiong   +7 more
doaj   +1 more source

Changing Patterns of Resistance to Ampicillin/Sulbactam [PDF]

, 1995
Objective: To report on methods to halt the increasing resistance of gram-negative organisms to ampicillin/sulbactam. Design: A before-after observational design was used to evaluate susceptibility of organisms to ampicillin/sulbactam.
Phillip F Pierce, Helen C Turner, Sally Usdin Yasuda, Mary A Young, Princy N Kumar, Joseph G Timpone   +5 more
core   +1 more source

Risk-factor analysis and predictive-model development of acute kidney injury in inpatients administered cefoperazone-sulbactam sodium and mezlocillin-sulbactam sodium: a single-center retrospective study [PDF]

, 2023
Objective: Acute kidney injury (AKI) is a common adverse reaction observed with the clinical use of cefoperazone-sulbactam sodium and mezlocillin-sulbactam sodium.
Xiao Li, Ruiqiu Zhang, Liming Gao, Weiguo Liu, Ping Chen, Xin Huang   +5 more
core   +1 more source

 -Lactamase Inhibition and In Vitro Activity of Sulbactam and Sulbactam/Cefoperazone [PDF]

Clinical Infectious Diseases, 1997
beta-Lactamase inhibitors such as sulbactam are beta-lactam compounds that have low antimicrobial activity but are able to inhibit enzymes (beta-lactamases) that destroy beta-lactam antibiotics like penicillins and cephalosporins. The main activity of beta-lactamase inhibitors is directed against plasmid-mediated transferable enzymes and various ...
openaire   +2 more sources