Results 21 to 30 of about 40,698 (218)

Cefotaxime/sulbactam: clinical and pharmacological characteristics [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2019
The recently approved cefotaxime/sulbactam, combination of third-generation cephalosporin (cefotaxime) and beta-lactamase inhibitor (sulbactam), can combat resistance mechanisms associated with the production of serine beta-lactamases, including some ...
Ortenberg E.A., Golub A.V.
doaj   +1 more source

Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography

IUCrJ, 2021
Here, we illustrate what happens inside the catalytic cleft of an enzyme when substrate or ligand binds on single-millisecond timescales. The initial phase of the enzymatic cycle is observed with near-atomic resolution using the most advanced X-ray ...
Suraj Pandey, George Calvey, Andrea M. Katz, Tek Narsingh Malla, Faisal H. M. Koua, Jose M. Martin-Garcia, Ishwor Poudyal, Jay-How Yang, Mohammad Vakili, Oleksandr Yefanov, Kara A. Zielinski, Sasa Bajt, Salah Awel, Katarina Doerner, Matthias Frank, Luca Gelisio, Rebecca Jernigan, Henry Kirkwood, Marco Kloos, Jayanath Koliyadu, Valerio Mariani, Mitchell D. Miller, Grant Mills, Garrett Nelson, Jose L. Olmos Jr, Alireza Sadri, Tokushi Sato, Alexandra Tolstikova, Weijun Xu, Abbas Ourmazd, John C. H. Spence, Peter Schwander, Anton Barty, Henry N. Chapman, Petra Fromme, Adrian P. Mancuso, George N. Phillips Jr, Richard Bean, Lois Pollack, Marius Schmidt   +39 more
doaj   +1 more source

Effect of β-lactamase inhibitors on in vitro activity of β-lactam antibiotics against Burkholderia cepacia complex species [PDF]

, 2016
Background: Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients. Intrinsic resistance to a wide range of antimicrobial agents, including a variety of beta-
Coenye, Tom, Everaert, Annelien
core   +2 more sources

In vitro synergism of combinations of colistin with selected antibiotics against colistin-resistant Acinetobacter baumannii

GMS Hygiene and Infection Control, 2014
[english] Aim: The in vitro activity of colistin in combination with sulbactam, netilmicin, and vancomycin against colistin-resistant strains was investigated. Furthermore, the clonal relationship of the strains was analyzed.
Percin, Duygu, Akyol, Selcan, Kalin, Gamze   +2 more
doaj   +1 more source

Antibiofilm Activity of β-Lactam/β-Lactamase Inhibitor Combination against Multidrug-Resistant Salmonella Typhimurium

Pathogens, 2022
This study was designed to assess the effect of β-lactam/β-lactamase inhibitor combinations on the inhibition of biofilm formation of Salmonella Typhimurium.
Nana Nguefang Laure, Juhee Ahn
doaj   +1 more source

Antibiotic-resistant Escherichia Coli from Retail Poultry Meat with Different Antibiotic Use Claims [PDF]

, 2018
Background We sought to determine if the prevalence of antibiotic-resistant Escherichia coli differed across retail poultry products and among major production categories, including organic, “raised without antibiotics”, and conventional.
Davis, Gregg S., Grande, Heidi, Horwinski, Joseph, Hungate, Bruce A., Koch, Benjamin, Liu, Cindy M., Nordstrom, Lora, Papp, Katerina, Price, Lance B., Waits, Kara, Weaver, Brett   +10 more
core   +2 more sources

The known-unknown: third- and fourth-generation cephalosporins combined with sulbactam [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2023
Despite the presence of more than 100 different antibacterials in the therapeutic arsenal, beta-lactam antibiotics, in general, and the third-generation cephalosporins, in particular, remain the main option for the treatment of the most of infections in ...
Stetsiouk O.U., Kovalenko T.N., Andreeva I.V., Belkova Yu.A.   +3 more
doaj   +1 more source

The Potential Role of Sulbactam and Cephalosporins Plus Daptomycin Against Daptomycin-Nonsusceptible VISA and H-VISA Isolates: An In Vitro Study

Antibiotics, 2019
This study assesses the synergistic effect of the combination of cephalosporins and sulbactam with daptomycin against daptomycin-nonsusceptible, vancomycin-intermediate resistant Staphylococcus aureus (VISA) or heterogeneous vancomycin-intermediate S ...
Chih-Cheng Lai, Chi-Chung Chen, Ying-Chen Lu, Tsuey-Pin Lin, Hung-Jui Chen, Bo-An Su, Chien-Ming Chao, Yin-Ching Chuang, Hung-Jen Tang   +8 more
doaj   +1 more source

The Surgical Infection Society revised guidelines on the management of intra-abdominal infection [PDF]

, 2017
Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. At the time the most recent guideline was released, the plan was to update
Chang, Phillip K, Diaz, Jose J, Jr, Huston, Jared M, May, Addison K, Mazuski, John E, Mollen, Kevin P, Nadler, Evan P, O\u27Neill, Patrick J, Prince, Jose M, Rosengart, Matthew R, Sawyer, Robert G, Tessier, Jeffrey M   +11 more
core   +3 more sources

Case Report: First Case of Cefotaxime-Sulbactam-Induced Acute Intravascular Hemolysis in a Newborn With ABO Blood Type Incompatibility by the Mechanism of Non-Immunologic Protein Adsorption

Frontiers in Immunology, 2021
BackgroundABO blood type incompatibility hemolytic disease of newborn (ABO-HDN) and drug-induced immune hemolytic anemia (DIIHA) due to non-immunologic protein adsorption (NIPA) mainly cause extravascular hemolysis.
Yuanjun Wu, Yong Wu, Yong Yang, Baochan Chen, Jianqun Li, Ganping Guo, Fu Xiong, Fu Xiong   +7 more
doaj   +1 more source