Results 41 to 50 of about 40,698 (218)

Ampicillin/Sulbactam-induced Hemolytic Anemia Manifested as Hyperbilirubinemia in a Preterm Infant [PDF]

, 2016
A female was born at 36+5 weeks of gestation with a birth weight of 2,120 g. Apgar score was 7 at 1 minute and 9 at 5 minutes. Shortly after birth, tachypnea, chest retraction, and a severe build-up of oral secretions were noted.
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core   +2 more sources

Combined PK/PD Index May Be a More Appropriate PK/PD Index for Cefoperazone/Sulbactam against Acinetobacter baumannii in Patients with Hospital-Acquired Pneumonia

Antibiotics, 2022
Cefoperazone/sulbactam (CPZ/SUL) is a β-lactam and β-lactamase inhibitor combination therapy for the treatment of respiratory tract infections. Using data from a prospective, multiple-center, open-label clinical trial in 54 patients with hospital ...
Yingjie Zhou, Jing Zhang, Yuancheng Chen, Jufang Wu, Beining Guo, Xiaojie Wu, Yingyuan Zhang, Minggui Wang, Ru Ya, Hao Huang   +9 more
doaj   +1 more source

Synthesis and evaluation of troponoids as a new class of antibiotics [PDF]

, 2018
Novel antibiotics are urgently needed. The troponoids [tropones, tropolones, and α-hydroxytropolones (α-HT)] can have anti-bacterial activity. We synthesized or purchased 92 troponoids and evaluated their antibacterial activities against Staphylococcus ...
Adegboyega, Patrick, Cao, Feng, Donlin, Maureen J., Elagawany, Mohamed, Elgendy, Bahaa, Meyers, Marvin J., Murelli, Ryan P., Orth, Cari, Tavis, John E.   +8 more
core   +4 more sources

Targeting USP22 to promote K63-linked ubiquitination and degradation of SARS-CoV-2 nucleocapsid protein

Journal of Virology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) generally hijacks the cellular machinery of host cells for survival. However, how SARS-CoV-2 employs the host’s deubiquitinase to facilitate virus replication remains largely unknown.
Xin Xiao, Shifeng Li, Zhijin Zheng, Yingying Ji, Qian Du, Yibo Zuo, Ying Miao, Yukang Yuan, Hui Zheng, Fang Huang, Jun Wang   +10 more
doaj   +1 more source

Evaluation of Fosfomycin-Sulbactam Combination Therapy against Carbapenem-Resistant Acinetobacter baumannii Isolates in a Hollow-Fibre Infection Model

Antibiotics, 2022
Static concentration in vitro studies have demonstrated that fosfomycin- or sulbactam-based combinations may be efficacious against carbapenem-resistant Acinetobacter baumannii (CRAB).
Sazlyna Mohd Sazlly Lim, Aaron Heffernan, Saiyuri Naicker, Steven Wallis, Jason A. Roberts, Fekade Bruck Sime   +5 more
doaj   +1 more source

Presence of New Delhi metallo-β-lactamase gene (NDM-1) in a clinical isolate of Acinetobacter junii in Argentina [PDF]

, 2016
Here we report the presence of a clinically significant A. junii blaNDM-1 positive in a 38-year-old woman who was admitted to the emergency department with a fever and leg ulcers with signs of infection.
Almuzara, Marisa, Barberis, Claudia, Cittadini, Roxana, Del Castillo M,, Lazzaro, T., Montaña, Sabrina Daiana, Ramírez, M. S., Uong, S., Vay, Carlos Alberto   +8 more
core   +1 more source

Current Therapeutic Approaches for Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Infections

Antibiotics
The treatment of Acinetobacter baumannii infections remains a challenge for physicians worldwide in the 21st century. The bacterium possesses a multitude of mechanisms to escape the human immune system. The consequences of A.
Petros Rafailidis, Periklis Panagopoulos, Christos Koutserimpas, George Samonis   +3 more
doaj   +1 more source

T.E.A. Study: three-day ertapenem versus three-day Ampicillin-Sulbactam. [PDF]

, 2013
Background: Intra-abdominal infections are one of the most common infections encountered by a general surgeon. However, despite this prevalence, standardized guidelines outlining the proper use of antibiotic therapy are poorly defined due to a lack of ...
Amaduzzi A, Ansaloni L, Baiocchi GL, Catena F, Coccolini F, Cucchi M, Di Saverio S, Lazzareschi D, Pasqualini E, Pinna AD, Sartelli M, Schiavina R, Vallicelli C   +12 more
core   +1 more source

Streamlining antibiotic use in community acquired pneumonia: A quality improvement initiative

Journal of Hospital Medicine, EarlyView.
Abstract Background Evidence suggests a 3‐day total duration and early transition to oral therapy is safe in hospitalized patients with community acquired pneumonia (CAP)—though such care is not standard in the United States. To implement these evidence‐based practices, a multidisciplinary group led by a hospitalist and antimicrobial stewardship ...
Claire E. Ciarkowski, Karen Howard, Hannah Imlay, Chaorong Wu, Christy L. Hopkins, Valerie M. Vaughn, Emily S. Spivak   +6 more
wiley   +1 more source

Penicillin kills chlamydia following the fusion of bacteria with Lysosomes and prevents genital inflammatory lesions in C. muridarum-infected mice [PDF]

, 2013
The obligate intracellular bacterium Chlamydia exists as two distinct forms. Elementary bodies (EBs) are infectious and extra-cellular, whereas reticulate bodies (RBs) replicate within a specialized intracellular compartment termed an ‘inclusion ...
Delarbre, C., Dumoux, Maud, Habbeddine, M., Hayward, Richard D., Kanellopoulos-Langevin, C., Le Gall, S.M., Ramsey, K., Verbeke, P.   +7 more
core   +5 more sources