Results 31 to 40 of about 29,384 (211)

Hypothermia from a two‐component mixture comprising Amoxicillin and Sulbactam

Clinical Case Reports, 2020
Hypothermia might be an adverse effect of Amoxicillin and/or Sulbactam, and clinicians should be aware of this effect. Further clinical and laboratory investigations are also needed to confirm and clarify the underlying mechanism of this side effect.
Tung Anh Dinh Duong, Ngoc Anh Hoang, Linh Doan Thi, Dung Bui Thi, Huong Pham Thi, Sang Nguyen Ngoc, Chien Bui Van, Thuc Dinh Van   +7 more
doaj   +1 more source

Pharmacokinetics of sulbactam in humans

Antimicrobial Agents and Chemotherapy, 1983
Sulbactam, a new beta-lactamase inhibitor, has pharmacokinetic characteristics in humans similar to those of ampicillin and amoxicillin. Its half-life in humans is approximately 1 h. In a two-compartment pharmacokinetic model, the apparent volume of distribution for the central compartment is approximately 12 liters, and half of the dose is found in ...
G, Foulds, J P, Stankewich, D C, Marshall, M M, O'Brien, S L, Hayes, D J, Weidler, F G, McMahon   +6 more
openaire   +3 more sources

Sulbactam-enhanced cytotoxicity of doxorubicin in breast cancer cells [PDF]

, 2018
Background Multidrug resistance (MDR) is a major obstacle in breast cancer treatment. The predominant mechanism underlying MDR is an increase in the activity of adenosine triphosphate (ATP)-dependent drug efflux transporters.
Kuan-rong Lee, Shey-chiang Su, Cheng-hao Lin, Shao-hsuan Wen, Bo-huang Liou   +4 more
core   +1 more source

A Randomized Controlled Trial of Colistin Combined with Sulbactam: 9 g per Day versus 12 g per Day in the Treatment of Extensively Drug-Resistant Acinetobacter baumannii Pneumonia: An Interim Analysis

Antibiotics, 2022
Extensively drug-resistant A. baumannii (XDRAB) pneumonia has a high mortality rate in hospitalized patients. One of the recommended treatments is colistin combined with sulbactam; however, the optimal dosage of sulbactam is unclear.
Chutchawan Ungthammakhun, Vasin Vasikasin, Dhitiwat Changpradub   +2 more
doaj   +1 more source

Use of ampicillin-sulbactam for treatment of experimental meningitis caused by a beta-lactamase-producing strain of Escherichia coli K-1 [PDF]

, 1991
We evaluated the pharmacokinetics and therapeutic efficacy of ampicillin combined with sulbactam in a rabbit model of meningitis due to a beta-lactamase-producing strain of Escherichia coli K-1. Ceftriaxone was used as a comparison drug.
Täuber, MG, Kennedy, SL, Tureen, JH, Guerra-Romero, L, Fournier, MA   +4 more
core   +1 more source

Combined PK/PD Index May Be a More Appropriate PK/PD Index for Cefoperazone/Sulbactam against Acinetobacter baumannii in Patients with Hospital-Acquired Pneumonia

Antibiotics, 2022
Cefoperazone/sulbactam (CPZ/SUL) is a β-lactam and β-lactamase inhibitor combination therapy for the treatment of respiratory tract infections. Using data from a prospective, multiple-center, open-label clinical trial in 54 patients with hospital ...
Yingjie Zhou, Jing Zhang, Yuancheng Chen, Jufang Wu, Beining Guo, Xiaojie Wu, Yingyuan Zhang, Minggui Wang, Ru Ya, Hao Huang   +9 more
doaj   +1 more source

Single-Dose Pharmacokinetics of Intravenous Sulbactam in Pediatric Patients [PDF]

, 1986
The pharmacokinetics of intravenously administered sulbactam were studied in 17 pediatric patients two to 14 years of age. Single doses of 12.5 or 25 mg/kg were infused over 3 min, and in previously healthy children, mean peak plasma concentrations 5 min
Kathrin Guenin, Guenin, Kathrin, Peter Straehl, Urs B. Schaad, Straehl, Peter, Schaad, Urs B.   +5 more
core   +1 more source

Targeting USP22 to promote K63-linked ubiquitination and degradation of SARS-CoV-2 nucleocapsid protein

Journal of Virology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) generally hijacks the cellular machinery of host cells for survival. However, how SARS-CoV-2 employs the host’s deubiquitinase to facilitate virus replication remains largely unknown.
Xin Xiao, Shifeng Li, Zhijin Zheng, Yingying Ji, Qian Du, Yibo Zuo, Ying Miao, Yukang Yuan, Hui Zheng, Fang Huang, Jun Wang   +10 more
doaj   +1 more source

Comparative pharmacokinetics of ampicillin-sulbactam combination in calves and sheep. [PDF]

, 1994
The pharmacokinetics of ampicillin and sulbactam administered in combination were studied in calves and sheep. The animals were administered an aqueous solution of ampicillin/sulbactam (2:1, w/w) intravenously and intramuscularly at doses of 13.2 and 6.6
Sonzogni O, Villa R, Belloli C, MONTESISSA, CLARA, Carli S.   +4 more
core   +3 more sources

Current Therapeutic Approaches for Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Infections

Antibiotics
The treatment of Acinetobacter baumannii infections remains a challenge for physicians worldwide in the 21st century. The bacterium possesses a multitude of mechanisms to escape the human immune system. The consequences of A.
Petros Rafailidis, Periklis Panagopoulos, Christos Koutserimpas, George Samonis   +3 more
doaj   +1 more source