Results 11 to 20 of about 14,994 (217)

Efficacy of pyrimethamine-sulfadoxine in young children with uncomplicated falciparum malaria in rural Burkina Faso

Malaria Journal, 2004
The efficacy of pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in young children of a malaria holoendemic area in rural Burkina Faso is reported.
Traore Corneille, Müller Olaf, Kouyate Bocar   +2 more
doaj   +2 more sources

Sulfadoxine-pyrimethamine pharmacokinetics in malaria: Pediatric dosing implications

Clinical Pharmacology & Therapeutics, 2006
Our objective was to characterize the pharmacokinetic properties of sulfadoxine-pyrimethamine in African adults and children with acute falciparum malaria. Despite decades of widespread use, there are few data to inform dose recommendations.In a prospective multicenter pharmacokinetic study in 307 patients with acute falciparum malaria, capillary blood
Barnes, K, Little, F, Smith, P, Evans, A, Watkins, WM, White, N   +5 more
openaire   +3 more sources

Efficacy of sulfadoxine-pyrimethamine, amodiaquine, and sulfadoxine-pyrimethamine–amodiaquine combination for the treatment of uncomplicated falciparum malaria in the urban and suburban areas of Brazzaville (Congo)

Acta Tropica, 2007
Congo-Brazzaville has recently adopted artesunate-amodiaquine as the first-line antimalarial drug to replace chloroquine. Before the implementation of this new strategy, we conducted several clinical studies to assess the therapeutic efficacy of former, classical first-line antimalarial drugs in the city of Brazzaville, in which reside about 30% of the
Ndounga, M., Mayengue, P. I., /Tahar, Rachida, Casimiro, P. N., Maya, D. W. M., Miakassissa Mpassi, V., Malonga, D. A., Nsonde Ntandou, F., Mallanda, G., /Ringwald, Pascal, /Basco, Leonardo, Ntoumi, F.   +11 more
openaire   +4 more sources

Immune responses to "Plasmodium falciparum" in Mozambican infants receiving Intermittent Preventive Treatment with Sulfadoxine Pyrimethamine [PDF]

, 2011
Malaria has a high toll on the lives of infants and children under the age of five in endemic areas. Control, and more recently, elimination agendas consist on implementing several measures simultaneously, including vector control, vaccines and drugs ...
Silveira Quelhas, Diana Iris
core   +6 more sources

DEVELOPMENT AND VALIDATION OF LC-MS METHOD FOR SIMULTANEOUS DETERMINATION OF PYRIMETHAMINE AND SULFADOXINE IN THE PHARMACEUTICAL PREPARATION [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2023
A simple, sensitive, accurate and precise liquid chromatography mass spectrometry (LC-MS) method was developed for determination of pyrimethamine and sulfadoxine in pharmaceutical formulation.
Mohamed Nassar, Ahmed El-Olemy, Mohamed Emara, Ahmed Ahmed   +3 more
doaj   +1 more source

Sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine plus amodiaquine for treating uncomplicated malaria [PDF]

Cochrane Database of Systematic Reviews, 2004
Artemisinin-based combination treatments are strongly advocated, but supplies are limited. Sulfadoxine combined with amodiaquine is an alternative non-artemisinin combination.To compare sulfadoxine-pyrimethamine plus amodiaquine (SP plus AQ) with sulfadoxine-pyrimethamine plus artesunate (SP plus AS) for treating uncomplicated Plasmodium falciparum ...
Bukirwa H, Critchley JA
openaire   +3 more sources

Declining trend of Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine in North Western Ethiopia. [PDF]

PLoS ONE, 2015
Antimalarial drug resistance is one of the major challenges in global efforts of malaria control and elimination. In 1998, chloroquine was abandoned and replaced with sulfadoxine/pyrimethamine, which in turn was replaced with artemether/lumefantrine for ...
Sofonias K Tessema, Moges Kassa, Amha Kebede, Hussein Mohammed, Gemechu Tadesse Leta, Adugna Woyessa, Geremew Tasew Guma, Beyene Petros   +7 more
doaj   +1 more source

Differentials in prevalence and correlates on uptake of tetanus toxoid and intermittent preventive treatment with sulfadoxine-pyrimethamine during pregnancy: A community-based cross-sectional study in The Gambia

SAGE Open Medicine, 2022
Objectives: The study examined the differentials in prevalence and correlates on the uptake of tetanus toxoid and intermittent preventive treatment of malaria among pregnant women in The Gambia.
Amadou Barrow, Sulayman Barrow, Amienatta Jobe   +2 more
doaj   +1 more source

Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa. [PDF]

, 2003
The selection of point mutation at codon 164 (from isoleucine to leucine) of the dihydrofolate reductase (DHFR) enzyme in Plasmodium falciparum is associated with high sulfadoxine /pyrimethamine (SP) resistance.
Watkins, W, Kimani, S, Kimani Serah, Kokwaro, Gilbert, Nzila, A, Mutabingwa, T, Kevin Marsh, Theonest Mutabingwa, Serah Kimani, Mutabingwa, Theonest, Gilbert Kokwaro, Nzila Alexis, Ochong, Edwin, Nzila, Alexis, Edwin Ochong, Kokwaro Gilbert, Kimani, Serah, Marsh Kevin, Marsh, K, Ochong Edwin, Alexis Nzila, Watkins, William, William Watkins, Kokwaro, G, Watkins William, Marsh, Kevin, Mutabingwa Theonest, Ochong, E   +27 more
core   +1 more source

Pharmacokinetic Properties of Sulfadoxine-Pyrimethamine in Pregnant Women [PDF]

Antimicrobial Agents and Chemotherapy, 2009
ABSTRACT To determine the pharmacokinetic disposition of sulfadoxine (SDOX) and pyrimethamine (PYR) when administered as intermittent presumptive treatment during pregnancy (IPTp) for malaria, 30 Papua New Guinean women in the second or third trimester of pregnancy and 30 age-matched nonpregnant women were given a single dose of ...
Karunajeewa, H., Salman, S., Mueller, I., Baiwog, F., Gomorrai, P., Law, I., Page-Sharp, Madhu, Rogerson, S., Siba, P., Ilett, K., Davis, T.   +10 more
openaire   +3 more sources