Results 41 to 50 of about 14,994 (217)

Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum. [PDF]

, 2006
OBJECTIVES: In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by Plasmodium falciparum. We measured the efficacy of the combination CQ/SP, and the prevalence
Targett Geoffrey A. T, Sutherland Colin J, Samuel Dunyo, Jawara, Musa, Coleman, Rosalind, Alexander Neal, Mesa, Eduardo, Sutherland, Colin J, Hallett, Rachel, Rachel Hallett, Ord Rosalynn, Coleman Rosalind, Musa Jawara, Geoffrey A. T Targett, Pinder Margaret, Jawara Musa, Ord, Rosalynn, Walraven, Gijs, Sowe, Maimuna, Targett, Geoffrey AT, Eduardo Mesa, Dunyo, Samuel, Neal Alexander, Colin J Sutherland, Rosalind Coleman, Gijs Walraven, Sowe Maimuna, Walraven Gijs, Mesa Eduardo, Alexander, Neal, Margaret Pinder, Dunyo Samuel, Rosalynn Ord, Maimuna Sowe, Pinder, Margaret, Hallett Rachel   +35 more
core   +1 more source

Chloroquine and Sulfadoxine–Pyrimethamine Resistance in Sub-Saharan Africa—A Review

Frontiers in Genetics, 2021
Malaria is a great concern for global health and accounts for a large amount of morbidity and mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the disease.
Alexandra T. Roux, Leah Maharaj, Olukunle Oyegoke, Oluwasegun P. Akoniyon, Matthew Adekunle Adeleke, Rajendra Maharaj, Moses Okpeku   +6 more
doaj   +1 more source

Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial.

, 2005
BACKGROUND: Many countries in Africa are considering a change to combination treatment for falciparum malaria because of the increase in drug resistance. However, there are few effectiveness data for these combinations.
Greenwood, Brian M, Hallett, Rachel, Mutabingwa, Theonest K, Drakeley, Chris, Whitty, Christopher JM, Anthony, Devota, Ahmed, Jalal, Heller, Archie   +7 more
core   +1 more source

High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children. [PDF]

, 2011
BACKGROUND: Drug resistance contributes to the global malaria burden. Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) polymorphisms confer resistance to sulphadoxine-pyrimethamine (SP). METHODS: The study assessed
Gabor, Julian J., Profanter, K., Grobusch, Martin P., Kurth, F., Grobusch, Martin P, Gabor, J.J., Gabor Julian J, Oyakhirome, Sunny, Oyakhirome, S., Kun, Jürgen FJ, Greutélaers, Benedikt, Jürgen FJ Kun, Grobusch Martin P, Kremsner, P.G., Issifou, Saadou, Kun, Jürgen F. J., Grobusch, M.P., Saadou Issifou, Issifou, S., Roper, C., Ord, Rosalynn, Roper, Cally, Mombo-Ngoma, Ghyslain, Peter G Kremsner, Greutélaers, K.C., Kremsner, Peter G., Katharina Profanter, Martin P Grobusch, Sunny Oyakhirome, Lell, Bertrand, Greutélaers, B., Greutélaers, Katja C., Greutélaers, Katja C, Kurth, Florian, Julian J Gabor, Rosalynn Ord, Mombo-Ngoma, G., Cally Roper, Florian Kurth, Issifou Saadou, Mombo-Ngoma Ghyslain, Ord Rosalynn, Gabor, Julian J, Oyakhirome Sunny, Kremsner, Peter G, Kun Jürgen FJ, Katja C Greutélaers, Ghyslain Mombo-Ngoma, Kurth Florian, Greutélaers Benedikt, Roper Cally, Profanter Katharina, Kun, J.F.J., Kremsner Peter G, Bertrand Lell, Lell Bertrand, Benedikt Greutélaers, Lell, B., Ord, R., Greutélaers Katja C, Profanter, Katharina   +60 more
core   +2 more sources

The impact of maternal antenatal treatment with two doses of azithromycin and monthly sulphadoxine-pyrimethamine on child weight, mid-upper arm circumference and head circumference: A randomized controlled trial.

PLoS ONE, 2019
AimIntermittent preventive treatment in pregnancy (IPTp) with azithromycin and monthly sulfadoxine-pyrimethamine increased the mean child weight, mid-upper arm and head circumference at four weeks of age in a rural low-income setting.
Lotta Hallamaa, Yin Bun Cheung, Mari Luntamo, Ulla Ashorn, Teija Kulmala, Charles Mangani, Per Ashorn   +6 more
doaj   +1 more source

Population-based validation of dihydrofolate reductase gene mutations for the prediction of sulfadoxine-pyrimethamine resistance in Uganda.

, 2003
Mutations in the dihydrofolate reductase gene (dhfr) of Plasmodium falciparum have been proposed as molecular markers for the surveillance of sulfadoxine-pyrimethamine (SP)-resistant malaria, but such proposals have not been validated. At 7 Ugandan sites
Watkins, W, Watkins, W., D'Alessandro, U., Langi, P., Egwang, T.G., Mutabingwa, T. K., Egwang, T. G., Mutabingwa, TK, Langi, P, Mutabingwa, T.K., Talisuna, A. O., D'Alessandro, U, Van Marck, E., d' Alessandro, U., Talisuna, A.O., Van Marck, E, Egwang, TG, Talisuna, AO   +17 more
core   +1 more source

RESPONSE OF FALCIPARUM MALARIA TO A COMBINATION OF QUININE AND SULFADOXINE-PYRIMETHAMINE IN BOOMY COUNTY OF LIBERIA

Pakistan Armed Forces Medical Journal, 2010
Objective: To document the response of Falciparum malaria to a combination of Quinine and sulfadoxine- Pyrimethamine in Boomy County of Liberia. Study Design: Quasi-experimental study. Place and duration of Study: Pak Level-II Hospital Tubmanburg, Boomy
Lt Col Muhammad Tariq, Asad Mehmood, Saleemullah .   +2 more
doaj   +2 more sources

Enhancing Maternal and Child Health: A Cross‐National Analysis of Nutrition Service Readiness in Sub‐Saharan Africa

Maternal &Child Nutrition, EarlyView.
Large variations exist in the availability of essential nutrition commodities and services across seven sub‐Saharan African countries, highlighting disparities in health system readiness. Despite high procurement rates for key commodities, logistical challenges impede consistent service delivery at the facilities, especially for newer interventions ...
Romance Dissieka, Djeinam Toure, Akriti Singh, Mahamadou Mansour Ndiath, Rolf D. W. Klemm   +4 more
wiley   +1 more source

Intermittent presumptive treatment in pregnancy with sulfadoxine–pyrimethamine: a counter perspective [PDF]

Malaria Journal, 2015
Malaria continues to cause devastation during pregnancy. Unfortunately, there is still no clear strategy to effectively protect pregnant women and countless mothers living in malaria endemic countries are dying every year. The effective prevention of malaria during pregnancy will take much more than the so-called "Global Call for Action" for an ...
Nosten, F, McGready, R
openaire   +3 more sources

Developmental Toxicity Study for the Antimalarial Drug Combination Cabamiquine‐Pyronaridine Using a Translational Approach

Birth Defects Research, Volume 118, Issue 10, October 2026.
ABSTRACT Background The safety of pharmacological treatments during pregnancy is a significant concern, as many medications lack comprehensive reproductive safety data. This creates gaps in therapeutic options for pregnant women, particularly malaria, which poses serious risks to maternal and fetal health.
Wookyung Kim, Geum‐Sil Cho, Andreas Gado, Tobias Hyun Ho Baeurle, Habib Karimi, Filippo Venezia, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, Claudia Demarta‐Gatsi   +9 more
wiley   +1 more source