Results 21 to 30 of about 14,994 (217)

Evolution of Resistance to Sulfadoxine-Pyrimethamine in Plasmodium falciparum [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACT The development of resistance to sulfadoxine-pyrimethamine by Plasmodium parasites is a major problem for the effective treatment of malaria, especially P. falciparum malaria.
Gatton, Michelle L., Martin, Laura B., Cheng, Qin   +2 more
openaire   +5 more sources

Effects of point mutations in Plasmodium falciparum dihydrofolate reductase and dihydropterate synthase genes on clinical outcomes and in vitro susceptibility to sulfadoxine and pyrimethamine. [PDF]

PLoS ONE, 2009
Sulfadoxine-pyrimethamine was a common first line drug therapy to treat uncomplicated falciparum malaria, but increasing therapeutic failures associated with the development of significant levels of resistance worldwide has prompted change to alternative
David J Bacon, Doug Tang, Carola Salas, Norma Roncal, Carmen Lucas, Lucia Gerena, Lorena Tapia, A Alejandro Llanos-Cuentas, Coralith Garcia, Lelv Solari, Dennis Kyle, Alan J Magill   +11 more
doaj   +1 more source

Protective efficacy of intermittent preventive treatment of malaria in infants (IPTi) using sulfadoxine-pyrimethamine and parasite resistance. [PDF]

, 2010
BACKGROUND: Intermittent Preventive Treatment of malaria in infants using sulfadoxine-pyrimethamine (SP-IPTi) is recommended by WHO for implementation in settings where resistance to SP is not high. Here we examine the relationship between the protective
Grobusch, Martin P., Gosling, Roly D., Ghani, Azra C, Daniel Chandramohan, Cairns, M., Matthew Cairns, Newman, R.D., Grobusch, Martin P, Schellenberg David, Newman, Robert D, Azra C Ghani, Gosling, R.D., Greenwood, Brian, Cairns, Matthew, Chandramohan Daniel, Jamie T. Griffin, Grobusch, M.P., Robert D Newman, Newman, Robert D., Roper, C., Schellenberg, D., Roper, Cally, Ghani, Azra C., Griffin, Jamie T, Greenwood Brian, Martin P Grobusch, Carneiro, Ilona, Jamie T Griffin, Chandramohan, Daniel, Ghani Azra C., Greenwood, B., Roly D Gosling, Schellenberg, David, Griffin, Jamie T., Cairns Matthew, Cally Roper, Gosling, Roly D, Gosling Roly D., Newman Robert D., Ghani, A.C., Martin P. Grobusch, Carneiro, I., Griffin Jamie T., Azra C. Ghani, Brian Greenwood, Daniel Ch, Griffin, J.T., Roper Cally, Roly D. Gosling, David Schellenberg, Grobusch Martin P., Roly D, Carneiro Ilona, Robert D. Newman, Chandramohan, D., Ilona Carneiro   +55 more
core   +3 more sources

The Effect of Artemisinin-Based Drugs vs Non-artemisinin-based Drugs on Gametophyte Carrying in the Body After the Treatment of Uncomplicated Falciparum Malaria: A Systematic Review and Meta-analysis

Frontiers in Pharmacology, 2022
The WHO recommends Artemisinin-based combination therapy (ACTs) as the first-line treatment for malaria. This meta-analysis aims to analyze the effects of artemisinin and its derivatives as well as non-artemisinin drugs on the gametophytes in the host ...
Yuanyuan Zou, Nadia Julie, Shiyuan Guo, Yexiao Tang, Hongying Zhang, Zhiyong Xu, Wanting Wu, Yueming Yuan, Zhibin Wu, Wenfeng Guo, Changqing Li, Xinan Huang, Qin Xu, Changsheng Deng, Jianping Song, Qi Wang, Qi Wang   +16 more
doaj   +1 more source

Sulfadoxine-pyrimethamine for uncomplicated falciparum malaria: Sulfadoxine-pyrimethamine is not working in Malawi [PDF]

BMJ, 2004
EDITOR—The paper by Plowe et al entitled “Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria” might be better titled “Sustained lack of efficacy of sulfadoxine-pyrimethamine….”1 By the start of the study period five years ago, molecular genotyping showed that Plasmodium falciparum in Malawi had already ...
openaire   +1 more source

Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania. [PDF]

, 2009
BACKGROUND: Malaria in pregnancy is serious, and drug resistance in Africa is spreading. Drugs have greater risks in pregnancy and determining the safety and efficacy of drugs in pregnancy is therefore a priority.
Greenwood, Brian M, Kandi Muze, Briceño, Marnie, Briceño Marnie, Christopher J. M. Whitty, Whitty Christopher J. M., Mutabingwa, Theonest K, I Muze, Drakeley, Chris, Ord Rosalynn, Chris Drakeley, Whitty, Christopher JM, Theonest K Mutabingwa, Ord, Rosalynn, Mutabingwa Theonest K., Drakeley Chris, Christopher J M Whitty, Theonest K. Mutabingwa, Greenwood Brian M., Brian M Greenwood, Rosalynn Ord, Brian M. Greenwood, Muze Kandi, Muze, Kandi, Marnie Briceño   +24 more
core   +1 more source

Stable high frequencies of sulfadoxine–pyrimethamine resistance associated mutations and absence of K13 mutations in Plasmodium falciparum 3 and 4 years after the introduction of artesunate plus sulfadoxine–pyrimethamine in Ujjain, Madhya Pradesh, India

Malaria Journal, 2020
Background Artesunate plus sulfadoxine–pyrimethamine (ASP) is first-line treatment for uncomplicated Plasmodium falciparum malaria in most of India, except for six North-eastern provinces where treatment failure rates were high. In Ujjain, central India,
Ashish Pathak, Andreas Mårtensson, Sudhir Gawariker, Ashish Sharma, Vishal Diwan, Manju Purohit, Johan Ursing   +6 more
doaj   +1 more source

Safety of sulfadoxine/pyrimethamine for intermittent preventive treatment of malaria in infants: evidence from large-scale operational research in southern Tanzania. [PDF]

, 2011
Intermittent preventive treatment with sulfadoxine/pyrimethamine (SP) is recommended for malaria prevention in infants (IPTi-SP). Serious adverse events, including Stevens-Johnson syndrome (SJS), have been reported following exposure to SP, but few ...
Schellenberg, David, Tanner, M., Kizito Shirima, Manzi, Fatuma, Hamisi, Y., Maokola, W., Marcel Tanner, Fatuma Manzi, Hassan Mshinda, Werner Maokola, Mrisho, Mwifadhi, Schellenberg, Joanna RM Armstrong, Barbara Willey, Pedro Alonso, Alonso, P., Mshinda, Hassan, Tanner, Marcel, Alonso, Pedro, Joanna R.M. Armstrong Schellenberg, Hamisi, Yuna, Schellenberg, D., Manzi, F., Yuna Hamisi, Chemba, Mwajuma, Chemba, M., Mwifadhi Mrisho, Mrisho, M., David Schellenberg, Mary Masanja, Masanja, M., Mshinda, H., Masanja, Mary, Shirima, Kizito, Willey, Barbara, Shirima, K., Willey, B., Mwajuma Chemba, Armstrong Schellenberg, J. R. M., Maokola, Werner   +38 more
core   +1 more source

Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine. [PDF]

, 2010
BACKGROUND\ud \ud It is argued that, the efficacy of anti-malarials could be prolonged through policy-mediated reductions in drug pressure, but gathering evidence of the relationship between policy, treatment practice, drug pressure and the evolution of ...
Abdulla, Salim, Bloland, Peter, Malisa, Allen L, Roper, Cally, Allen L Malisa, Salim Abdulla, Cally Roper, Patrick S Kachur, Peter Bloland, Hassan Mshinda, Kachur, Patrick S, Richard J Pearce, Pearce, Richard J, Mshinda, Hassan   +13 more
core   +1 more source

Frequency of Pfcrt T76 and Pfdhfr Asn-108 Drug Resistance Mutations in falciparum Malaria in Southeastern Malaria Endemic Area of Iran [PDF]

Iranian Journal of Public Health, 2008
Background: Point mutations in the genes, Pfcrt and Pfdhfr, have been identified elsewhere as strongly associated with re­sistance to chloroquine (CQ) and pyrimethamine, respectively.
MR Razavi, SR Naddaf, JLe Bras, A Raesi, AR Esmaeili, M Assmar   +5 more
doaj   +1 more source