Results 51 to 60 of about 10,379 (219)

Use of population pharmacokinetic‐pharmacodynamic modelling to inform antimalarial dose optimization in infants

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 968-980, April 2025.
Infants bear a significant malaria burden but are usually excluded from participating in early dose optimization studies that inform dosing regimens of antimalarial therapy. Unlike older children, infants' exclusion from early‐phase trials has resulted in limited evidence to guide accurate dosing of antimalarial treatment for uncomplicated malaria or ...
Clifford G. Banda, Joel Tarning, Karen I. Barnes   +2 more
wiley   +1 more source

Antimalarial drug sulfadoxine induces gametocytogenesis in Plasmodium berghei

Malaria Journal
Background The spread of antimalarial drug resistance parasites is a major obstacle in eliminating malaria in endemic areas. This increases the urgency for developing novel antimalarial drugs with improved profiles to eliminate both sensitive and ...
Wihda Aisarul Azmi, Andita Fitri Mutiara Rizki, Achmad Shidiq, Yenny Djuardi, I Made Artika, Josephine Elizabeth Siregar   +5 more
doaj   +1 more source

Pharmacokinetics of a Novel Piperaquine Dispersible Granules Formulation Under Fasting and Various Fed Conditions Versus Piperaquine Tablets When Fasted in Healthy Tanzanian Adults: A Randomized, Phase I Study

Clinical and Translational Science, Volume 18, Issue 2, February 2025.
ABSTRACT Piperaquine tetraphosphate (PQP), a long‐acting antimalarial, is being considered in a combination for chemoprevention. Dihydroartemisinin‐piperaquine tablets (hard and dispersible) approved for the treatment of acute uncomplicated malaria should be administered in a fasted state, as PQP bioavailability increases with food.
Florence A. Milando, Said Jongo, Salim Abdulla, Gloria Nyaulingo, Anneth‐Mwasi Tumbo, Sarah Mswata, Juliether Tiago, Beatus S. Bongole, Ashura Mirambo, Kamaka Kassimu, Hussein Mbarak, Mohammed A. Rashid, Ali Hamad, Michael Mihayo, Tunu Ndanzi, Omary Zuberi, Naima Saadia, Mariam Somboka, Mariam Yamba‐Yamba, Theresia Ngonyani, Amina Nditi, Margaret Msuya, Bakari Mwalimu, Hajirani M. Msuya, Khamis Awadh, Ali Ali, Anne Claire Marrast, Denis Gossen, Alice Neequaye, Myriam El‐Gaaloul, Hanu Ramachandruni, Isabelle Borghini‐Fuhrer   +31 more
wiley   +1 more source

Evidence of triple mutant Pfdhps ISGNGA haplotype in Plasmodium falciparum isolates from North-east India: An analysis of sulfadoxine resistant haplotype selection

Genomics Data, 2016
Background: North-east region of India has consistent role in the spread of multi drug resistant Plasmodium (P.) falciparum to other parts of Southeast Asia.
Manuj K. Das, Sumi Chetry, Mohan C. Kalita, Prafulla Dutta   +3 more
doaj   +1 more source

Highly Water‐Stable 2D MOF as Dual Sensor for the Ultra‐Sensitive Aqueous Phase Detection of Nitrofuran Antibiotics and Organochlorine Pesticides

Small, Volume 21, Issue 3, January 22, 2025.
A chemically robust (aqueous pH = 3‐12 for a day and 3 months in water) Cd‐MOF (IITKGP‐71) is strategically developed for ultrasensitive detection of Nitrofuran (NFZ and NFT) antibiotics and DCN pesticide with high selectivity, rapid responsiveness and excellent recyclability in aqueous medium.
Supriya Mondal, Rupam Sahoo, Madhab C. Das   +2 more
wiley   +1 more source

Experiences, acceptability and barriers to calcium supplementation during pregnancy in Dar es Salaam, Tanzania

Maternal &Child Nutrition, Volume 21, Issue 1, January 2025.
We assessed experiences, acceptability and barriers to higher‐dose calcium supplementation from the perspectives of pregnant women and antenatal health care providers in Dar es Salaam, Tanzania. Calcium supplementation was acceptable to pregnant women.
Emmy O. Metta, Alfa Muhihi, Heavenlight A. Paulo, Christopher R. Sudfeld, Anna Kaale, Nandita Perumal, Mary Mwanyika‐Sando, Ndeniria O. Swai, Christopher P. Duggan, Honorati Masanja, Blair J. Wylie, Andrea B. Pembe, Wafaie Fawzi   +12 more
wiley   +1 more source

Spectrophotometric Estimation of Sulfadoxine in Pharmaceutical Preparations

E-Journal of Chemistry, 2010
Four simple, sensitive, accurate and rapid visible spectrophotometric methods (A, B, C and D) have been developed for the estimation of sulfadoxine in pharmaceutical preparations. They are based on the diazotization of sulfadoxine with sodium nitrite and
Sangita Sharma, Madhurjya Neog, Vipul Prajapati, Hiren Patel, Dipti Dabhi   +4 more
doaj   +1 more source

Comparative Evaluation of the Dynamics of Parameters of Cell-Mediated Immunity under the Influence of Different Therapies for Chronic Acquired Toxoplasmosis

Aktualʹnaâ Infektologiâ, 2015
The article presents a comparative evaluation of the dynamics of parameters of cell-mediated immunity in patients under the influence of different therapies for chronic acquired toxoplasmosis (CAT).
O.V. Bobrova, Anuar al Hatib
doaj   +1 more source

Meta-analysis on Plasmodium falciparum sulfadoxine-pyrimethamine resistance-conferring mutations in India identifies hot spots for genetic surveillance

, 2023
Abhinav Sinha, Sonalika Kar, Charu Chauhan, Chander Prakash Yadav, Lokesh Kori   +4 more
openalex   +1 more source

Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru

Brazilian Journal of Infectious Diseases
The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru.
A. Llanos-Cuentas, P. Campos, M. Clendenes, C. J. Canfield, D. B. A. Hutchinson   +4 more
doaj   +1 more source