Results 61 to 70 of about 21,364 (252)

Detection of Falsified Antimalarial Sulfadoxine-Pyrimethamine and Dihydroartemisinin-Piperaquine Drugs Using a Low-Cost Handheld Near-Infrared Spectrometer

Journal of Analytical Methods in Chemistry, 2022
Falsified drugs are of serious concern to public health worldwide, particularly for developing countries where quality control of drugs is inefficient.
Moussa Yabré, Abdoul Karim Sakira, Moumouni Bandé, Bertrand W. F. Goumbri, Sandrine M. Ouattara, Souleymane Fofana, Touridomon Issa Somé   +6 more
doaj   +1 more source

Efficacy of chloroquine, sulphadoxine-pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in Kajo Keji county, Sudan. [PDF]

, 2004
To provide advice on the rational use of antimalarial drugs, Médecins Sans Frontières conducted a randomized, an open label efficacy study in Kajo Keji, an area of high transmission of malaria in southern Sudan.
Epicentre, Krishna S, Kshirsagar NA, National Malaria Administration/Unicef, Ochong EO, Omari AA, Seidlein L, UN/OCHA, Vugt M, WHO, WHO, WHO, WHO, WHO/Roll Back Malaria   +13 more
core   +2 more sources

A Novel Inhibitor against the Bromodomain Protein 1 of the Malaria Pathogen Plasmodium Falciparum

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
This article presents the development of a first‐in‐class inhibitor targeting the bromodomain protein PfBDP1 in Plasmodium falciparum, the deadliest variant of the malaria‐causing Plasmodium parasites. Through structure‐based drug design, the inhibitor interactions were characterized via X‐ray crystallography and isothermal titration calorimetry ...
Marius Amann, Robin Warstat, Kay Kristin Rechten, Philip Theuer, Magdalena Schustereder, Sophie Clavey, Bernhard Breit, Oliver Einsle, Martin Hügle, Michaela Petter, Stefan Günther   +10 more
wiley   +1 more source

A Randomized Open-Label Evaluation of the Antimalarial Prophylactic Efficacy of Azithromycin-Piperaquine versus Sulfadoxine-Pyrimethamine in Pregnant Papua New Guinean Women

Antimicrobial Agents and Chemotherapy, 2019
Emerging malaria parasite sulfadoxine-pyrimethamine (SP) resistance has prompted assessment of alternatives for intermittent preventive treatment in pregnancy (IPTp).
B. Moore, J. Benjamin, Roselyn Tobe, M. Ome-Kaius, Gumul Yadi, Bernadine Kasian, Charles Kong, L. Robinson, M. Laman, I. Mueller, S. Rogerson, T. Davis   +11 more
semanticscholar   +1 more source

Frequency of Pfcrt T76 and Pfdhfr Asn-108 Drug Resistance Mutations in falciparum Malaria in Southeastern Malaria Endemic Area of Iran [PDF]

Iranian Journal of Public Health, 2008
Background: Point mutations in the genes, Pfcrt and Pfdhfr, have been identified elsewhere as strongly associated with re­sistance to chloroquine (CQ) and pyrimethamine, respectively.  Methods: Using a restriction digestion method, we ...
MR Razavi, SR Naddaf, JLe Bras, A Raesi, AR Esmaeili, M Assmar   +5 more
doaj   +2 more sources

Artesunate-, sulfadoxine-, and pyrimethamine-induced cardiotoxicity

BLDE University Journal of Health Sciences, 2016
Here, we report oral artesunate, sulphadoxine and pyrimethamine (sp) induced cardio toxicity case in a female patient. Artesunate is a highly efficacious and relatively safe antimalarial drug.
Divya Goel, Shafiqa Aslam, Rani Walia, Akshay Sadhotra   +3 more
doaj   +1 more source

Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia [PDF]

, 2017
Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle-cell burden exists, remain unknown.
Hodges, James S., Hume, Heather A., John, Chandy C., Kasirye, Phillip, Lane, Adam, Latham, Teresa S., Ndugwa, Christopher M., Opoka, Robert O., Ware, Russell E.   +8 more
core   +2 more sources

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, Volume 12, Issue 19, May 22, 2025.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source

Molecular markers of resistance to amodiaquine plus sulfadoxine–pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Malaria Journal, 2018
In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine–pyrimethamine (AQ + SP) is recommended in the ...
R. Grais, I. Laminou, Lynda Woi-Messe, Rockyath Makarimi, Seidou H. Bouriema, C. Langendorf, A. Amambua-Ngwa, U. d’Alessandro, P. Guérin, T. Fandeur, C. Sibley   +10 more
semanticscholar   +1 more source

Impact of antimalarial resistance and COVID-19 pandemic on malaria care among pregnant women in Northern Uganda (ERASE): protocol of a prospective observational study

BMC Infectious Diseases, 2022
Background Uganda accounts for 5% of all malaria cases and deaths reported globally and, in endemic countries, pregnancy is a risk factor for both acquisition of P. falciparum infection and development of severe malaria.
Francesco Vladimiro Segala, Francesco Di Gennaro, Jerry Ictho, Mariangela L’Episcopia, Emmanuel Onapa, Claudia Marotta, Elda De Vita, James Amone, Valentina Iacobelli, Joseph Ogwang, Giovanni Dall’Oglio, Benedict Ngole, Rita Murri, Lameck Olal, Massimo Fantoni, Samuel Okori, Giovanni Putoto, Carlo Severini, Peter Lochoro, Annalisa Saracino   +19 more
doaj   +1 more source