Results 71 to 80 of about 20,006 (291)

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, Volume 12, Issue 19, May 22, 2025.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source

Factors affecting uptake of ≥ 3 doses of Sulfadoxine-Pyrimethamine for malaria prevention in pregnancy in selected health facilities, Arusha region, Tanzania

BMC Pregnancy and Childbirth, 2019
BackgroundTanzania adopted the revised World Health Organization policy in 2013 recommending a minimum of ≥3 doses of Intermittent Preventive Treatment during pregnancy with Sulfadoxine-Pyrimethamine (IPTp-SP) to protect against malaria.
W. Mchwampaka, D. Tarimo, Frank Chacky, A. Mohamed, R. Kishimba, Angela Samwel   +5 more
semanticscholar   +1 more source

Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. [PDF]

, 2003
Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected.
Keus, K, Nzila, A, Ochong, E, van den Broek, I   +3 more
core   +1 more source

Frequency of Pfcrt T76 and Pfdhfr Asn-108 Drug Resistance Mutations in falciparum Malaria in Southeastern Malaria Endemic Area of Iran [PDF]

Iranian Journal of Public Health, 2008
Background: Point mutations in the genes, Pfcrt and Pfdhfr, have been identified elsewhere as strongly associated with re­sistance to chloroquine (CQ) and pyrimethamine, respectively.
MR Razavi, SR Naddaf, JLe Bras, A Raesi, AR Esmaeili, M Assmar   +5 more
doaj   +1 more source

Miniaturized green liquid‐phase sample pre‐concentration methods for pharmaceutical drugs assessment in wastewater

Water and Environment Journal, Volume 39, Issue 2, Page 143-167, May 2025.
Abstract Microextraction methods such as hollow fibre‐liquid phase microextraction (HF‐LPME), dispersive liquid–liquid microextraction (DLLME), single‐drop microextraction (SDME) and ultrasound‐assisted emulsification microextraction (USAEME) have become prominent for analysing pharmaceuticals in wastewater. HF‐LPME, particularly the three‐phase system,
Bavuyile Magqira, Precious Mahlambi
wiley   +1 more source

Detection of Falsified Antimalarial Sulfadoxine-Pyrimethamine and Dihydroartemisinin-Piperaquine Drugs Using a Low-Cost Handheld Near-Infrared Spectrometer

Journal of Analytical Methods in Chemistry, 2022
Falsified drugs are of serious concern to public health worldwide, particularly for developing countries where quality control of drugs is inefficient.
Moussa Yabré, Abdoul Karim Sakira, Moumouni Bandé, Bertrand W. F. Goumbri, Sandrine M. Ouattara, Souleymane Fofana, Touridomon Issa Somé   +6 more
doaj   +1 more source

A Randomized Open-Label Evaluation of the Antimalarial Prophylactic Efficacy of Azithromycin-Piperaquine versus Sulfadoxine-Pyrimethamine in Pregnant Papua New Guinean Women

Antimicrobial Agents and Chemotherapy, 2019
Emerging malaria parasite sulfadoxine-pyrimethamine (SP) resistance has prompted assessment of alternatives for intermittent preventive treatment in pregnancy (IPTp).
B. Moore, J. Benjamin, Roselyn Tobe, M. Ome-Kaius, Gumul Yadi, Bernadine Kasian, Charles Kong, L. Robinson, M. Laman, I. Mueller, S. Rogerson, T. Davis   +11 more
semanticscholar   +1 more source

Availability and Utilization of Malaria Prevention Strategies in Pregnancy in Eastern India [PDF]

, 2010
BACKGROUND. Malaria in pregnancy in India, as elsewhere, is responsible for maternal anemia and adverse pregnancy outcomes such as low birth weight and preterm birth.
Banerjee, Camellia, Brooks, Mohamad I., Dash, Aditya P., Desai, Meghna, Hamer, Davidson H., Hashmi, Ahmar H., Hussain, Mobassir, MacLeod, William B., Sabin, Lora, Singh, Mrigendra P., Singh, Neeru, Tuchman, Jordan, Udhayakumar, Venkatachalam, Wylie, Blair J, Yeboah-Antwi, Kojo   +14 more
core   +3 more sources

Use of population pharmacokinetic‐pharmacodynamic modelling to inform antimalarial dose optimization in infants

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 968-980, April 2025.
Infants bear a significant malaria burden but are usually excluded from participating in early dose optimization studies that inform dosing regimens of antimalarial therapy. Unlike older children, infants' exclusion from early‐phase trials has resulted in limited evidence to guide accurate dosing of antimalarial treatment for uncomplicated malaria or ...
Clifford G. Banda, Joel Tarning, Karen I. Barnes   +2 more
wiley   +1 more source

Effects of maternal antenatal treatment with two doses of azithromycin added to monthly sulfadoxine-pyrimethamine for the prevention of low birth weight in Burkina Faso: an open-label randomized controlled trial

Malaria Journal, 2023
Background Exposure during pregnancy to malaria and sexually-transmitted infections is associated with adverse birth outcomes including low birth weight (LBW).
Moussa Lingani, Serge H. Zango, Innocent Valéa, Sékou Samadoulougou, Georges Somé, Maïmouna Sanou, Berenger Kaboré, Toussaint Rouamba, Herman Sorgho, Marc C. Tahita, Karim Derra, Michèle Dramaix, Halidou Tinto, Philippe Donnen, Annie Robert   +14 more
doaj   +1 more source