Results 21 to 30 of about 1,739 (182)

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, EarlyView.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

Removal of sulfamic acid from plutonium sulfamate--sulfamic acid solution [PDF]

, 1978
Plutonium metal can be readily dissolved in aqueous solutions of sulfamic acid. When the plutonium sulfamate--sulfamic acid solutions are added to normal purex process streams, the sulfamate ion is oxidized by addition of sodium nitrite. This generates sodium sulfate which must be stored as radioactive waste.
openaire   +2 more sources

Bioactive Aliphatic Sulfates from Marine Invertebrates

Marine Drugs, 2019
The occurrence of sulfated steroids and phenolics in marine organisms is quite widespread, being typically reported from Echinoderms. In contrast, alkane and alkene aliphatic sulfates are considerably rarer with examples being reported from a diverse ...
Luis C. Kellner Filho, Bruno W. Picão, Marcio L. A. Silva, Wilson R. Cunha, Patricia M. Pauletti, Gustavo M. Dias, Brent R. Copp, Camila S. Bertanha, Ana H. Januario   +8 more
doaj   +1 more source

Comparison of the Sulfonamide Inhibition Profiles of the α-Carbonic Anhydrase Isoforms (SpiCA1, SpiCA2 and SpiCA3) Encoded by the Genome of the Scleractinian Coral Stylophora pistillata

Marine Drugs, 2019
The ubiquitous metalloenzymes carbonic anhydrases (CAs, EC 4.2.1.1) are responsible for the reversible hydration of CO2 to bicarbonate (HCO3−) and protons (H+).
Sonia Del Prete, Silvia Bua, Fatmah A. S. Alasmary, Zeid AlOthman, Sylvie Tambutté, Didier Zoccola, Claudiu T. Supuran, Clemente Capasso   +7 more
doaj   +1 more source

Bacterial carbonic anhydrases as drug targets: towards novel antibiotics ?

Frontiers in Pharmacology, 2011
Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes which catalyze the hydration of carbon dioxide to bicarbonate and protons. Many pathogenic bacteria encode such enzymes belonging to the a-, b-, and/or g-CA families.
Claudiu T. Supuran
doaj   +1 more source

Bench‐Stable Boryl Thianthrenium Dication Enables Aziridinyl Boronate Synthesis via Metal‐Free Late‐Stage Aziridination with Diverse Nitrogen Nucleophiles

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A bench‐stable boryl thianthrenium dication is synthesized via thianthrenation of vinyl MIDA boronate. This novel dication enables metal‐free, chemo‐, and diastereoselective late‐stage aziridination with diverse nitrogen nucleophiles. The strategic significance is further showcased by one‐pot electrochemical and asymmetric protocols and versatile ...
Veerabhadra R. Vulupala, Disni Gunasekera, Nagarjun R. Mallampudi, Ramy Yousef, Yusif I. Gyasi, Gopal R. Ramidi, Ifeoluwa Adedotun, Shiqing Xu   +7 more
wiley   +2 more sources

Stereochemistry matters: Inhibition of carbonic anhydrase II by amino acid derived sulfamates depends on their absolute configuration

European Journal of Medicinal Chemistry Reports
Aminoalcohols were converted into the corresponding enantiomeric phenylsulfonamide sulfamates. These compounds proved to be inhibitors of carbonic anhydrase II.
Toni C. Denner, Elsa L. Klett, Niels V. Heise, René Csuk   +3 more
doaj   +1 more source

Nickel‐Catalyzed Amination of Aryl Sulfamates [PDF]

Angewandte Chemie International Edition, 2011
Carbon–nitrogen bonds are ubiquitous in medicinal agents and natural products.[1] Transition metal-catalyzed amination reactions, pioneered by Buchwald and Hartwig, are amongst the most powerful methods available for accessing these motifs.[1] Copper- and palladium-mediated aminations of aryl halides and triflates are now well-established,[1] and ...
Stephen D, Ramgren, Amanda L, Silberstein, Yang, Yang, Neil K, Garg   +3 more
openaire   +2 more sources

Synthesis and Enzymatic Evaluation of a Small Library of Substituted Phenylsulfonamido-Alkyl Sulfamates towards Carbonic Anhydrase II

Molecules
A small library of 79 substituted phenylsulfonamidoalkyl sulfamates, 1b–79b, was synthesized starting from arylsulfonyl chlorides and amino alcohols with different numbers of methylene groups between the hydroxyl and amino moieties yielding intermediates
Toni C. Denner, Niels V. Heise, Ahmed Al-Harrasi, René Csuk   +3 more
doaj   +1 more source

Bifunctional Aziridines from Photochemically Generated FSO2NH2 for SuFEx Diversification of Alkenes

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Photochemically generated FSO2NH2 serves as a safe, practical nitrene precursor for Rh‐catalyzed aziridination of alkenes, granting access to previously inaccessible fluorosulfonyl aziridines. These bifunctional electrophiles merge aziridine ring strain with SuFEx reactivity to provide a modular platform toward aliphatic sulfamoyl fluoride derivatives ...
Avinash Choudhury, Varun Prabhakar, Zakary B. Newman, Quentin Michaudel   +3 more
wiley   +2 more sources