Results 1 to 10 of about 31,137 (305)

The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases

Frontiers in Pharmacology, 2016
Gynecological diseases such as endometriosis, adenomyosis and uterine fibroids, and gynecological cancers including endometrial cancer and ovarian cancer, affect a large proportion of women.
Tea eLanisnik Rizner
exaly   +4 more sources

SulfAtlas, the sulfatase database: state of the art and new developments [PDF]

Nucleic Acids Res., 2022
SulfAtlas (https://sulfatlas.sb-roscoff.fr/) is a knowledge-based resource dedicated to a sequence-based classification of sulfatases. Currently four sulfatase families exist (S1–S4) and the largest family (S1, formylglycine-dependent sulfatases) is ...
Mark Stam, Pernelle Lelièvre, Mark Hoebeke, Erwan Corre, Tristan Barbeyron, Gurvan Michel   +5 more
openalex   +2 more sources

Identification of a Sulfatase that Detoxifies Glucosinolates in the Phloem-Feeding Insect Bemisia tabaci and Prefers Indolic Glucosinolates

Frontiers in Plant Science, 2021
Cruciferous plants in the order Brassicales defend themselves from herbivory using glucosinolates: sulfur-containing pro-toxic metabolites that are activated by hydrolysis to form compounds, such as isothiocyanates, which are toxic to insects and other ...
Abinaya Manivannan, Bhawana Israni, Katrin Luck, Monika Götz, Elena Seibel, Michael L. A. E. Easson, Roy Kirsch, Michael Reichelt, Beate Stein, Stephan Winter, Jonathan Gershenzon, Daniel Giddings Vassão   +11 more
doaj   +2 more sources

Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases

Nature Communications, 2021
Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases longevity. Here we show that loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase (STS), raises the pool of sulfated
Mercedes Maria Pérez-Jiménez, José Manuel Monje Moreno, Mónica Venegas Calerón   +2 more
exaly   +2 more sources

Natural history of multiple sulfatase deficiency: Retrospective phenotyping and functional variant analysis to characterize an ultra‐rare disease

Journal of Inherited Metabolic Disease, 2020
Multiple sulfatase deficiency (MSD) is an ultra‐rare neurodegenerative disorder caused by pathogenic variants in SUMF1. This gene encodes formylglycine‐generating enzyme (FGE), a protein required for sulfatase activation.
Laura Adang, Lars Schlotawa, Samuel Groeschel, Christiane Kehrer, K. Harzer, Orna Staretz‐Chacham, Thiago Oliveira Silva, Ida Vanessa Döederlein Schwartz, Jutta Gärtner, Mauricio De Castro, Carrie Costin, Esperanza Font–Montgomery, Thomas Dierks, Karthikeyan Radhakrishnan, Rebecca C. Ahrens‐Nicklas   +14 more
openalex   +2 more sources

Drug screening identifies tazarotene and bexarotene as therapeutic agents in multiple sulfatase deficiency

EMBO Molecular Medicine, 2023
Multiple sulfatase deficiency (MSD, MIM #272200) results from pathogenic variants in the SUMF1 gene that impair proper function of the formylglycine‐generating enzyme (FGE).
Lars Schlotawa, Karolina Tyka, Matthias Kettwig, Rebecca C Ahrens‐Nicklas, Matthias Baud, Tea Berulava, Nicola Brunetti‐Pierri, Alyssa Gagne, Zackary M Herbst, Jean A Maguire, Jlenia Monfregola, Tonatiuh Pena, Karthikeyan Radhakrishnan, Sophie Schröder, Elisa A Waxman, Andrea Ballabio, Thomas Dierks, André Fischer, Deborah L French, Michael H Gelb, Jutta Gärtner   +20 more
doaj   +2 more sources

Sulfatase-cleavable linkers for antibody-drug conjugates

Chemical Science, 2020
Antibody-drug conjugates (ADCs) are a class of targeted drug delivery agents combining the cell-selectivity of monoclonal antibodies (mAbs) and the cytotoxicity of small molecules.
Jonathan D Bargh, Stephen J Walsh, Albert Isidro-Llobet   +2 more
exaly   +2 more sources

Multiple Sulfatase Deficiency: A Disease Comprising Mucopolysaccharidosis, Sphingolipidosis, and More Caused by a Defect in Posttranslational Modification

International Journal of Molecular Sciences, 2020
Multiple sulfatase deficiency (MSD, MIM #272200) is an ultra-rare disease comprising pathophysiology and clinical features of mucopolysaccharidosis, sphingolipidosis and other sulfatase deficiencies. MSD is caused by impaired posttranslational activation
Lars Schlotawa, Laura A Adang, Karthikeyan Radhakrishnan   +2 more
exaly   +2 more sources

Insights into Hunter syndrome from the structure of iduronate-2-sulfatase

Nature Communications, 2017
Hunter syndrome is a rare but devastating childhood disease caused by mutations in the IDS gene encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate.
Chris H Hill, Aiwu Zhou, Janet E Deane
exaly   +2 more sources

The Significance of the Sulfatase Pathway for Local Estrogen Formation in Endometrial Cancer

Frontiers in Pharmacology, 2017
Endometrial cancer (EC) is the most common estrogen-dependent gynecological malignancy in the developed World. To investigate the local formation of estradiol (E2), we first measured the concentrations of the steroid precursor androstenedione (A-dione ...
Maša Sinreih, Tamara Knific, Maja Anko, Neli Hevir, Katja Vouk, Aleš Jerin, Snježana Frković Grazio, Tea Lanišnik Rižner   +7 more
doaj   +2 more sources