Results 101 to 110 of about 28,914 (292)

Inhalable Nano Formulation of Cabazitaxel: A Comparative Study with Intravenous Route

Macromolecular Bioscience, Volume 25, Issue 5, May 2025.
Nano drug formulation shows no signs of toxicity for IV and INH routes, whereas higher systemic toxicity occurs in free drug formulation in both. Inhalable nano formulation provides higher and longer retention in deep lung regions due to its size and defies rapid systemic absorption in the lungs.
Elif Kaga, Sadik Kaga, Korhan Altunbas, Nurullah Okumus   +3 more
wiley   +1 more source

Steroid Sulfatase Deficiency and Androgen Activation Before and After Puberty

Journal of Clinical Endocrinology and Metabolism, 2016
Context: Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including dehydroepiandrosterone (DHEA) sulfate (DHEAS), the inactive sulfate ester of the adrenal androgen precursor DHEA. Deficient DHEA sulfation, the opposite enzymatic
J. Idkowiak, A. Taylor, S. Subtil, Donna M. O’Neil, R. Vijzelaar, R. Dias, R. Amin, T. Barrett, C. Shackleton, J. Kirk, Celia Moss, W. Arlt   +11 more
semanticscholar   +1 more source

Trauma promotes heparan sulfate modifications and cleavage that disrupt homeostatic gene expression in microvascular endothelial cells

Frontiers in Cell and Developmental Biology
Introduction: Heparan sulfate (HS) in the vascular endothelial glycocalyx (eGC) is a critical regulator of blood vessel homeostasis. Trauma results in HS shedding from the eGC, but the impact of trauma on HS structural modifications that could influence ...
Robert P. Richter, Robert P. Richter, James D. Odum, Camilla Margaroli, Jessica C. Cardenas, Lei Zheng, Kaushlendra Tripathi, Zhangjie Wang, Katelyn Arnold, Ralph D. Sanderson, Jian Liu, Jillian R. Richter, Jillian R. Richter   +12 more
doaj   +1 more source

Self‐Assembly of Noncanonical Peptides: A New Frontier in Cancer Therapeutics and Beyond

Macromolecular Bioscience, EarlyView.
Representative examples of noncanonical peptide assemblies in anticancer therapeutics, biomaterials, regenerative medicine, molecular imaging, and catalysis are discussed, highlighting enzyme‐instructed self‐assembly as a valuable approach for constructing biomimetic and bioinspired materials that bridge the interface between biological systems and ...
Lin Bai, Meihui Yi, Bing Xu
wiley   +1 more source

Multiple Sulfatase Deficiency (MSD): Review of the Literature and Case Reports of Two Siblings with Dental Caries and Trauma

Case Reports in Pediatrics, 2021
Multiple sulfatase deficiency (MSD) (MIM # 272200) is an extraordinarily rare inborn error of metabolism (IEM). The phenotypic spectrum is largely heterogeneous and attributed to the combined effects of deficiencies in the nine sulfatases currently known
Lorna Hirst, Gehan Abou-Ameira, Mari-Liis Uudelepp   +2 more
doaj   +1 more source

Chromosome assignment of two cloned DNA probes hybridizing predominantly to human sex chromosomes [PDF]

, 1984
In situ hybridization experiments were carried out with two clones, YACG 35 and 2.8, which had been selected from two genomic libraries strongly enriched for the human Y chromosome.
A Chapelle de la, AJ Solari, AJ Solari, BD Young, BR Migeon, C Cremer, CR M�ller, CR M�ller, D Page, DT Denhardt, EMJ Southern, GM Wahl, J Fantes, JBS Haldane, JW Gray, KE Davies, L Zech, LM Kunkel, LM Kunkel, MJ Moses, P Goodfellow, P Leder, P Polani, PK Horan, PL Pearson, PN Dean, PN Dean, PN Goodfellow, PS Burgoyne, PS Gerhard, R Krumlauf, RG Langlois, SP Daiger, T Mohandas, U M�ller   +34 more
core   +1 more source

Cooked Broccoli Alters Cecal Microbiota and Impacts Microbial Metabolism of Glucoraphanin in Lean and Obese Mice

Molecular Nutrition &Food Research, Volume 69, Issue 6, March 2025.
Seven‐day cooked broccoli feeding increased the ability of the gut microbiota to metabolize glucoraphanin (GRP) into beneficial isothiocyanates (ITCs) leading to increased colonic NQO1 activity. Gut microbiota shifted, with Lachnospiraceae NK4A136 group and Dubosiella newyorkensis increasing on broccoli diet.
Anqi Zhao, Jiaxuan Li, Mark Peterson, Molly Black, Christopher A. Gaulke, Elizabeth H. Jeffery, Michael J. Miller   +6 more
wiley   +1 more source

Functional assessment of the genetic findings indicating mucopolysaccharidosis type II in the prenatal setting

JIMD Reports, 2021
Mucopolysaccharidosis type II (MPS II) is a multi‐systemic disorder arising due to pathogenic variants in the gene located on chromosome Xq28 encoding the lysosomal enzyme, iduronate 2‐sulfatase (IDS).
Maria Fuller, David Ketteridge
doaj   +1 more source

Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method. [PDF]

, 2013
Rottlerin is a natural polyphenolic ketone isolated from the pericarps of Mallotus phillippinensis. In previous studies we showed that parenteral administration of rottlerin reduced tumor growth in murine xenograft models of pancreatic cancer. The aim of
Edderkaoui, Mouad, Eibl, Guido, Go, Vay-Liang, Lu, Qing-Yi, Lugea, Aurelia, Moro, Aune, Pandol, Stephen, Zhang, Lifeng   +7 more
core   +1 more source

Using molecular docking to investigate the anti-breast cancer activity of low molecular weight compounds present on wild mushrooms. [PDF]

, 2011
Mushrooms represent an unlimited source of compounds with antitumor and immunostimulating properties and mushroom intake as been shown to reduce the risk of breast cancer.
Abreu, Rui M.V., Ferreira, Isabel C.F.R., Froufe, Hugo J.C.   +2 more
core   +1 more source