Results 41 to 50 of about 31,866 (306)

Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer

open access: yesMolecular Cancer, 2005
Hsulf-1 is a newly identified enzyme, which has the ability to decrease the growth of hepatocellular, ovarian, and head and neck squamous cell carcinoma cells by interfering with heparin-binding growth factor signaling.
Giese Nathalia A   +8 more
doaj   +1 more source

Multiple Sulfatase Deficiency: A Disease Comprising Mucopolysaccharidosis, Sphingolipidosis, and More Caused by a Defect in Posttranslational Modification

open access: yesInternational Journal of Molecular Sciences, 2020
Multiple sulfatase deficiency (MSD, MIM #272200) is an ultra-rare disease comprising pathophysiology and clinical features of mucopolysaccharidosis, sphingolipidosis and other sulfatase deficiencies. MSD is caused by impaired posttranslational activation
Lars Schlotawa   +3 more
semanticscholar   +1 more source

Post-synthetic regulation of HS structure: the yin and yang of the Sulfs in Cancer

open access: yesFrontiers in Oncology, 2014
Heparan sulfate (HS) is a complex polysaccharide that takes part in most major cellular processes, through its ability to bind and modulate a very large array of proteins.
Romain R Vives   +2 more
doaj   +1 more source

The Effect of Glucosinolates on the Growth and Development of Helicoverpa armigera Larvae and the Expression of Midgut Sulfatase Genes

open access: yesAgronomy, 2022
The plant–pest interaction and its mechanisms are a novel research direction for pest control. They provide molecular targets for developing new pesticides and targeted control measures to control insect herbivores.
Xue Li   +7 more
doaj   +1 more source

Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. [PDF]

open access: yes, 2008
Sulfatase modifying factor 1 (SUMF1) encodes for the formylglicine generating enzyme, which activates sulfatases by modifying a key cysteine residue within their catalytic domains. SUMF1 is mutated in patients affected by multiple sulfatase deficiency, a
Annunziata F.   +10 more
core   +1 more source

Orthopedic management of the extremities in patients with Morquio A syndrome. [PDF]

open access: yes, 2014
BackgroundMusculoskeletal involvement in Morquio A syndrome (mucopolysaccharidosis IVA; MPS IVA) contributes significantly to morbidity and mortality. While the spinal manifestations of the disorder have received considerable attention in the literature,
Bache, C Edward   +6 more
core   +1 more source

Metabolomics application in maternal-fetal medicine [PDF]

open access: yes, 2013
Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant
Atzori, L   +4 more
core   +4 more sources

The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers

open access: yesFrontiers in Pharmacology, 2017
Endometrial and ovarian cancers predominately affect women after menopause, and are more frequently observed in developed countries. These are considered to be hormone-dependent cancers, as steroid hormones, and estrogens in particular, have roles in ...
Tea Lanišnik Rižner   +2 more
doaj   +1 more source

Identification of a Sulfatase that Detoxifies Glucosinolates in the Phloem-Feeding Insect Bemisia tabaci and Prefers Indolic Glucosinolates

open access: yesFrontiers in Plant Science, 2021
Cruciferous plants in the order Brassicales defend themselves from herbivory using glucosinolates: sulfur-containing pro-toxic metabolites that are activated by hydrolysis to form compounds, such as isothiocyanates, which are toxic to insects and other ...
Abinaya Manivannan   +11 more
doaj   +1 more source

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