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Incorporation of sulfhydryl compounds into melanins in vitro

Biochimica et Biophysica Acta (BBA) - General Subjects, 1988
Cysteine is known to be involved in pheomelanin synthesis. Available evidence, however, indicates that glutathione may also play an important role in melanogenesis. This in vitro study clarifies how cysteine and glutathione participate in melanogenesis.
S, Ito, Y, Imai, K, Jimbow, K, Fujita
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Detoxification of urotoxic oxazaphosphorines by sulfhydryl compounds

Journal of Cancer Research and Clinical Oncology, 1981
Urotoxic side effects, especially hemorrhagic cystitis, have so far been a limiting factor in the therapeutic use of cyclophosphamide (Endoxan), ifosfamide (Holoxan), and trofosfamide (Ixoten). The uroprotective agent mesna (Uromitexan) allows regional detoxification in the kidney and the urinary tract, and thus clinical prevention of the urotoxic side
N, Brock, J, Pohl, J, Stekar
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Reaction of malformin with sulfhydryl compounds

Phytochemistry, 1970
Abstract Malformin reacts with the sulfhydryl compounds, cysteine and β-mercaptoethanol, to form an insoluble 1:1 addition product. This reaction may explain the ability of thiol compounds to inhibit the activity of malformin and suggests reaction of malformin with thiol compounds in vivo .
Shinobu Iriuchijima, Roy W. Curtis
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Sulfhydryl Compounds as Thermosensitizers

1988
The cytotoxic effects of a number of widely used chemotherapeutic agents have been reported to be enhanced by heat (Hahn 1979; Hahn and Li 1982). The exact mechanism of this enhancement is not fully understood and might differ with the various compounds. Thermosensitization by sulfhydryl compounds in vitro has been observed by Kapp and Hahn (1979).
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