Results 111 to 120 of about 25,968 (166)
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Protection of sulfhydryl compounds against ionizing radiation
Biochimica et Biophysica Acta, 1963Cysteamine was shown to provide strong protection against x-ray inactivation of papain and of a small molecular compound, CoA, in solutions. The mechanism involved modification of their -SH groups. It is concluded that results are compatible with the hypothesis that the protection afforded by sulfhydryl compounds in vivo may be due in part to blocking ...
A, PIHL, T, SANNER
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Role of Sulfhydryls in the Hepatotoxicity of Organic and Metallic Compounds
Toxicological Sciences, 1985Endogenous sulfhydryl compounds serve a critical role in maintaining the function and viability of living systems. Glutathione (GSH) is the most abundant of these nonprotein thiols. During the past decade it has been demonstrated that sulfhydryls such as GSH also serve an important role in protecting vital nucleophilic sites in the liver from ...
C D, Klaassen +5 more
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Alteration of lymphocyte response by sulfhydryl and disulfide compounds
Biochemical Pharmacology, 1979Abstract The effects on the proliferative response of human lymphocytes of the sulfhydryl agents d -penicillamine and 5-thiopyridoxine, some analogues of these agents, and their respective disulfides were investigated. The sulfhydryl agents inhibited the proliferation of mitogen-stimulated lymphocytes and suppressed the mixed lymphocyte reaction ...
P F, Merryman, J, Nowakowski, I A, Jaffe
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Products of the reaction of peroxyacetyl nitrate with sulfhydryl compounds
Archives of Biochemistry and Biophysics, 1969Abstract Peroxyacetyl nitrate reacts with reduced glutathione producing oxidized glutathione and S -acetyl glutathione. Reaction of peroxyacetyl nitrate with reduced coenzyme A results in the formation of coenzyme A disulfide, accounting for 35–45% of the reacted sulfhydryl. The remaining products can be separated by ion exchange chromatography and
J B, Mudd, T T, McManus
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Role of sulfhydryl compounds in the Bactericidal effect of metronidazole
Biochemical Pharmacology, 1983The bactericidal effect of metronidazole on Escherichia coli and Bacteroides fragilis can be partially reversed by cysteamine under conditions that lead to the formation of an adduct, the thioether, 4-(2-aminoethyl)thio-2-methylimidazole-1-ethanol (4-ATME). This adduct, which is not mutagenic for the Ames histidine auxotrophs of Salmonella typhimurium,
T C, Yeung, P, Goldman
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Sulfhydryl Compounds May Mediate Gastric Cytoprotection
Science, 1981Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein sulfhydryl compounds in rat gastric mucosa. Sulfhydryl-containing drugs protect rats from ethanol-induced gastric erosions, whereas sulfhydryl blocking agents counteract the mucosal cytoprotective effect of prostaglandin F
S, Szabo, J S, Trier, P W, Frankel
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Products of the reaction of selenite with intracellular sulfhydryl compounds
Biological Trace Element Research, 1991The usual first step in the intracellular metabolism of exogenous selenite is its chemical reaction with glutathione to form selenodiglutathione (1). We have investigated whether selenite also reacts intracellularly with other SH compounds. HeLa cells were exposed to [75Se]selenite and lysed with SDS.
G D, Frenkel, D, Falvey, C, MacVicar
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In vivo depression of hepatic succinoxidase by sulfhydryl compounds
Biochemical and Biophysical Research Communications, 1971Abstract Thioglycolate injected i.v. in dosages of 50 mg/kg, significantly depressed hepatic succinoxidase in immature rats of either sex and adult males whereas, about a five-fold excess was required to elicit a significant response in adult females. Ovariectomy increased and estradiol pretreatment, decreased the sensitivity to thioglycolate.
S, Bakshy, L L, Gershbein
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The Inhibition of Metabolic Oxalate Production by Sulfhydryl Compounds
Journal of Urology, 1991A number of sulfhydryl compounds were shown to inhibit CO2 and oxalate formation from glyoxylate by rat liver homogenates and hepatocytes. The most significant inhibition occurred with cysteine and this inhibition was concentration-dependent. In rats made hyperoxaluric by administering ethylene glycol in their drinking water, daily intraperitoneal ...
R, Bais, A M, Rofe, R A, Conyers
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The reduction of experimentally induced inflammation by sulfhydryl compounds
Biochemical Pharmacology, 1967Abstract The sulfhydryl compounds acetylcysteine and acetylpenicillamine were found to reduce the severity of induced dermal inflammation in rabbits when the compounds were administered in repeated doses. Treatment with acetylcysteine and salicylate given concomitantly resulted in an anti-inflammatory response which was equal to that obtained with ...
K R, Bailey, A L, Sheffner
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