Results 241 to 250 of about 1,607,740 (290)
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Role of sulfhydryl compounds in the Bactericidal effect of metronidazole
Biochemical Pharmacology, 1983The bactericidal effect of metronidazole on Escherichia coli and Bacteroides fragilis can be partially reversed by cysteamine under conditions that lead to the formation of an adduct, the thioether, 4-(2-aminoethyl)thio-2-methylimidazole-1-ethanol (4-ATME). This adduct, which is not mutagenic for the Ames histidine auxotrophs of Salmonella typhimurium,
T C, Yeung, P, Goldman
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Sulfhydryl Compounds May Mediate Gastric Cytoprotection
Science, 1981Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein sulfhydryl compounds in rat gastric mucosa. Sulfhydryl-containing drugs protect rats from ethanol-induced gastric erosions, whereas sulfhydryl blocking agents counteract the mucosal cytoprotective effect of prostaglandin F
S, Szabo, J S, Trier, P W, Frankel
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Alteration of lymphocyte response by sulfhydryl and disulfide compounds
Biochemical Pharmacology, 1979Abstract The effects on the proliferative response of human lymphocytes of the sulfhydryl agents d -penicillamine and 5-thiopyridoxine, some analogues of these agents, and their respective disulfides were investigated. The sulfhydryl agents inhibited the proliferation of mitogen-stimulated lymphocytes and suppressed the mixed lymphocyte reaction ...
P F, Merryman, J, Nowakowski, I A, Jaffe
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Products of the reaction of peroxyacetyl nitrate with sulfhydryl compounds
Archives of Biochemistry and Biophysics, 1969Abstract Peroxyacetyl nitrate reacts with reduced glutathione producing oxidized glutathione and S -acetyl glutathione. Reaction of peroxyacetyl nitrate with reduced coenzyme A results in the formation of coenzyme A disulfide, accounting for 35–45% of the reacted sulfhydryl. The remaining products can be separated by ion exchange chromatography and
J B, Mudd, T T, McManus
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The Inhibition of Metabolic Oxalate Production by Sulfhydryl Compounds
Journal of Urology, 1991A number of sulfhydryl compounds were shown to inhibit CO2 and oxalate formation from glyoxylate by rat liver homogenates and hepatocytes. The most significant inhibition occurred with cysteine and this inhibition was concentration-dependent. In rats made hyperoxaluric by administering ethylene glycol in their drinking water, daily intraperitoneal ...
R, Bais, A M, Rofe, R A, Conyers
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Protection of sulfhydryl compounds against ionizing radiation
Biochimica et Biophysica Acta, 1963Cysteamine was shown to provide strong protection against x-ray inactivation of papain and of a small molecular compound, CoA, in solutions. The mechanism involved modification of their -SH groups. It is concluded that results are compatible with the hypothesis that the protection afforded by sulfhydryl compounds in vivo may be due in part to blocking ...
A, PIHL, T, SANNER
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The effect of sulfhydryl compounds on sister-chromatid exchanges
Mutation Research/Genetic Toxicology, 1980We examined the SH compounds glutathione (GSH), cysteine (CYS), cysteamine (MEA) and 2-mercaptoethanol (MET) with regard to their capacity for inducing SCEs. Whereas cysteamine and 2-mercaptoethanol increased the SCE frequency, this did not happen with glutathione and cysteine.
G, Speit, M, Wolf, W, Vogel
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Toxicity of sulfhydryl compounds to cultured human lymphocytes
Experimental Cell Research, 1970Abstract The toxicity of cysteine metabolites for cultured human lymphocytes decreases with proximity in the metabolic pathways to the usual organic excretory product, taurine. Polyploidy induction also roughly parallels toxicity.
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Enzymic methylation of foreign sulfhydryl compounds
Biochimica et Biophysica Acta, 1961Abstract A new transmethylating enzyme system in mammalian tissues, catalyzing methyl transfer from S-adenosylmethionine to sulfhydryl compounds, has been studied. A series of “nonphysiological” sulfhydryl compounds (BAL, mercaptoethanol, O-methyl-mercaptoethanol, mercaptoacetic acid, β-mercaptoproprionic acid, methymercaptan and hydrogen sulfide ...
Jon Bremer, David M. Greenberg
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In Vitro Reduction of Tetrazolium Indicators by Sulfhydryl Compounds
Stain Technology, 1954There was considerable variation between the sulfhydryl induced in vitro reduction of the oxidation-reduction indicators (2,3,5-triphenyltetrazolium chloride, 2,3-diphenyl 5-methyl tetrazolium chloride, neotetrazolium chloride, neotetrazolium phosphate-2B, blue tetrazolium, tetrazolium violet, potassium tellurite, methylene blue, and resazurin).
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