Results 51 to 60 of about 21,408 (208)
Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase
Cell Reports, 2016 In many organisms, hydroxyurea (HU) inhibits class I ribonucleotide reductase, leading to lowered cellular pools of deoxyribonucleoside triphosphates. The reduced levels for DNA precursors is believed to cause replication fork stalling. Upon treatment of
Li Phing Liew +6 more
doaj +1 more source
Bioaugmentation of Overloaded Anaerobic Digesters Restores Function and Archaeal Community [PDF]
, 2015 Adding beneficial microorganisms to anaerobic digesters for improved performance (i.e. bioaugmentation) has been shown to decrease recovery time after organic overload or toxicity upset.
Maki, James +2 more
core +2 more sources
Structural basis of RNA polymerase inhibition by viral and host factors
Nature Communications, 2021 Understanding the structural basis for the inhibition of archaeal eukaryotic-like RNA polymerases (RNAPs) during virus infection is of interest for drug design.
Simona Pilotto +9 more
doaj +1 more source
Frontiers in Microbiology, 2021 Sulfolobaceae family, comprising diverse thermoacidophilic and aerobic sulfur-metabolizing Archaea from various geographical locations, offers an ideal opportunity to infer the evolutionary dynamics across the members of this family.
Rachana Banerjee +13 more
doaj +1 more source
Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes [PDF]
, 2015 Until relatively recently, DNA primases were viewed simply as a class of proteins that synthesize short RNA primers requisite for the initiation of DNA replication.
Aidan J. Doherty +17 more
core +1 more source
Journal of Microbiology and Biotechnology, 2015 A Sulfolobus-E. coli shuttle vector for an efficient expression of the target gene in S. acidocaldarius strain was constructed. The plasmid-based vector pSM21 and its derivative pSM21N were generated based on the pUC18 and Sulfolobus cryptic plasmid pRN1. They carried the S.
Sungmin, Hwang +3 more
openaire +2 more sources
Dimer-dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba [PDF]
, 2013 Archaea use a variety of small basic proteins to package their DNA. One of the most widespread and highly conserved is the Alba (Sso10b) protein. Alba interacts with both DNA and RNA in vitro, and we show in the present study that it binds more tightly ...
Ingledew, W John +3 more
core +1 more source
Recent Progress on Enzyme Immobilization: Materials, Strategies, and Applications
Food Bioengineering, EarlyView.Enzyme immobilization technology has undergone substantial evolution driven by advances in materials science. This review systematically examines the recent advances in enzyme immobilization since 2024, with a focused analysis of five major categories of enzyme carriers including covalent organic framework, metal‐organic frameworks, polymers, carbon ...
Shuran Wang +7 more
wiley +1 more source
Phylogenetic differences in content and intensity of periodic proteins [PDF]
, 2005 Many proteins exhibit sequence periodicity, often correlated with a visible structural periodicity. The statistical significance of such periodicity can be assessed by means of a chi-square-based test, with significance thresholds being calculated from ...
Gatherer, D., McEwan, N.R.
core +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma +3 more
wiley +1 more source