Results 111 to 120 of about 114,841 (367)

Origin of the Mobile Di-Hydro-Pteroate Synthase Gene Determining Sulfonamide Resistance in Clinical Isolates

bioRxiv, 2018
Sulfonamides are synthetic chemotherapeutic agents that work as competitive inhibitors of the di-hydro-pteroate synthase (DHPS) enzyme, encoded by the folP gene.
Miquel Sánchez-Osuna, P. Cortés, J. Barbé, Ivan Erill   +3 more
semanticscholar   +1 more source

Nurses\u27 Alumnae Association Bulletin - Volume 3 Number 5 [PDF]

, 1944
Jefferson Marches On Christmas Packages The United States Cadet Nurse Corps and Jefferson Medical College Hospital Attention Promotions Welcome, Miss Hopkins Student Nurse Activities Scholarship Girls Taking Anaesthesia Our Office and Teaching Staff ...
Elliott, Margaret, Knowles, H. J
core   +1 more source

Asymmetric additions to dienes catalysed by a dithiophosphoric acid. [PDF]

, 2011
Chiral Brønsted acids (proton donors) have been shown to facilitate a broad range of asymmetric chemical transformations under catalytic conditions without requiring additional toxic or expensive metals.
Hamilton, Gregory, Rauniyar, Vivek, Shapiro, Nathan, TOSTE, F. Dean, Wu, Jeffrey   +4 more
core   +2 more sources

X‐ray controlled release strategy in cancer therapy

BMEMat, EarlyView.
A comprehensive review on the design principles and current strategies of X‐ray stimulated release systems in cancer therapy, focusing on the X‐ray responsive functional groups and materials as well as discussing the advantages and current challenges of X‐ray controlled release systems in cancer therapy.
Yiling Ruan, Hongxiang Huang, Huihui Liu, Jinglang Gong, Changjun Li, Xiaolian Sun   +5 more
wiley   +1 more source

Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors targeting the α-class enzyme from the protozoan pathogen Trypanosoma cruzi, responsible of Chagas disease, were recently reported.
Alane Beatriz Vermelho, Verônica da Silva Cardoso, Eduardo Ricci Júnior, E. D. dos Santos, C. Supuran   +4 more
semanticscholar   +1 more source

Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein [PDF]

, 2018
In this report, we present a new benzoxazole derivative endowed with inhibitory activity against the HIV-1 nucleocapsid protein (NC). NC is a 55-residue basic protein with nucleic acid chaperone properties, which has emerged as a novel and potential ...
Botta, Maurizio, Fabris, Dan, Gamba, Elia, Gatto, Barbara, Giannini, Alessia, Kovalenko, Lesia, Mely, YVES CAMILLE RENE', Mori, Mattia, Saladini, Francesco, Sosic, Alice   +9 more
core   +2 more sources

Advances in Ligand‐Driven Pd‐Catalyzed C─H Functionalizations: Recent Insights and Updates

ChemCatChem, EarlyView.
The most significant advances in ligand‐driven Pd‐catalyzed organic synthesis over the past two years are presented. Processes involving C─H activation of substrates, avoiding their prefunctionalization are illustrated. Both the activity and selectivity of the catalyst depend on the design of the ligands (pyridones, pyridines, amino acids, phosphines ...
Jesús Moradell, Cosmina Bohan, Alexandra Pop, Esteban P. Urriolabeitia   +3 more
wiley   +1 more source

Neuropharmacological Assessment of Sulfonamide Derivatives of Para-Aminobenzoic Acid through In Vivo and In Silico Approaches

Drugs and Drug Candidates
Background/Objectives: Alzheimer’s disease (AD), a complex neurogenerative disorder, manifests as dementia and concomitant neuropsychiatric symptoms, including apathy, depression, and circadian disruption.
Ankit Ganeshpurkar, Ravi Singh, Pratigya Tripathi, Qadir Alam, Sairam Krishnamurthy, Ashok Kumar, Sushil Kumar Singh   +6 more
doaj   +1 more source

Assessment of the antiproliferative and apoptotic roles of sulfonamide carbonic anhydrase IX inhibitors in HeLa cancer cell line

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Carbonic anhydrase IX (CA IX) has recently been validated as an antitumor/antimetastatic drug target. In this study, we examined the underlying molecular mechanisms and the anticancer activity of sulfonamide CA IX inhibitors against cervical cancer cell ...
Ismail Koyuncu, Ataman Gonel, Mustafa Durgun, Abdurrahim Kocyigit, Ozgur Yuksekdag, Claudiu T. Supuran   +5 more
doaj   +1 more source

Radical‐Mediated Sulfonylarylation of Unactivated Alkynes via Intramolecular 1,4‐(hetero)aryl Migration

ChemistryEurope, EarlyView.
A photoredox neutral sulfonylarylation of unactivated alkynes is achieved through a radical‐mediated intramolecular 1,4‐(hetero)aryl migration. The product configuration can be controlled under the irradiation of blue or green light. The method features mild, transition metal‐free conditions, good compatibility of functional groups, and high levels of ...
Xu Zhang, Fushan Chen, Chen Zhu
wiley   +1 more source