Results 111 to 120 of about 77,925 (335)

Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations. [PDF]

, 2018
Interactions of drug molecules with lipid membranes play crucial role in their accessibility of cellular targets and can be an important predictor of their therapeutic and safety profiles.
Bekker, Slava, Clancy, Colleen E, DeMarco, Kevin R, Noskov, Sergei Y, Vorobyov, Igor   +4 more
core  

Genomic Insights Into the Population and Antibiotic Resistance Changes of Salmonella Pullorum in China

Animal Research and One Health, EarlyView.
Salmonella Pullorum strains in China are categorized into three phylogenetic clades. Clade 1 strains have all been isolated in the past 15 years. The population size of S. pullorum in China saw a significant decline between 2003 and 2016, reflecting the effectiveness of purification efforts.
Ke Wu, Jie Zhang, Jing Zuo, Qian Chen, Honglin Peng, Changwei Lei, Hongning Wang   +6 more
wiley   +1 more source

Tandem chalcone-sulfonamide hybridization, cyclization and further Claisen–Schmidt condensation: Tuning molecular diversity through reaction time and order and catalyst

Arabian Journal of Chemistry, 2020
We here report the synthesis of novel chalcone-sulfonamide compounds based on the hybridization at 2′ position and nitro substitution at the side chalcone phenyl ring followed by tandem cyclization into quinolinone derivatives and then a further aldol ...
Mirian R.C. de Castro, Raquel Ferreira Naves, Aline Bernardes, Cameron Capeletti da Silva, Caridad Noda Perez, Andrea Felinto Moura, Manoel Odorico de Moraes, Felipe Terra Martins   +7 more
doaj  

Inhibition of the α-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
We discovered novel and selective sulfonamides/amides acting as inhibitors of the α-carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic bacterium Vibrio cholerae (VchCA).
Daniela De Vita, Andrea Angeli, Fabiana Pandolfi, Martina Bortolami, Roberta Costi, Roberto Di Santo, Elisabetta Suffredini, Mariangela Ceruso, Sonia Del Prete, Clemente Capasso, Luigi Scipione, Claudiu T. Supuran   +11 more
doaj   +1 more source

Crystal structure of methyl 1-methyl-3,5-diphenyl-7-tosyl-3,6,7,11b-tetrahydropyrazolo[4′,3′:5,6]pyrano[3,4-c]quinoline-5a(5H)-carboxylate

Acta Crystallographica Section E, 2014
In the title compound, C35H31N3O5S, the piperidine ring adopts an envelope conformation, with the methine C atom as the flap, and the pyran ring adopts a sofa conformation.
Eswar Kumar Nadendla, G. Jagadeesan, D. Kannan, Mannickam Bakthadoss, K. Gunasekaran   +4 more
doaj   +1 more source

Targeting Tumor-Associated Carbonic Anhydrases in Photothermal Therapy. [PDF]

ChemMedChem
Tumor‐associated carbonic anhydrases hCA IX and hCA XII, are overexpressed in hypoxic tumor regions and promote cancer cell survival. Targeting these enzymes enhances the efficacy of photothermal therapy (PTT), which uses NIR light for localized heat and apoptosis, representing a promising approach for cancer treatment.
Clément S, Richeter S, Winum JY.
europepmc   +2 more sources

Exploring quinolinone–chalcones: Synthesis, antioxidant potential and industrial applications in biofuels

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Biofuels undergo oxidative degradation, which reduces their storage stability and efficiency, hindering their large‐scale adoption and integration into the global energy matrix. To address this issue, we synthesized and characterized four novel quinolinone–chalcone derivatives (substituted with Br, Cl, OCH3 and OCH2CH3) as potential ...
Vitor S. Duarte, Renata Layse G. de Paula, Leonardo R. Almeida, Giulio D. C. D’Oliveira, Caridad N. Pérez, Jean M. F. Custódio, Valter H. Carvalho‐Silva, Andrea Lombardi, Hamilton B. Napolitano   +8 more
wiley   +1 more source

EFFECT OF SULFONAMIDES AND THIOUREA DERIVATIVES ON HEART RATE AND ORGAN MORPHOLOGY [PDF]

, 1944
C. P. Leblond, HEBBEL E. HOFF
openalex   +1 more source

An assessment of organic solvent based equilibrium partitioning methods for predicting the bioconcentration behavior of perfluorinated sulfonic acids, carboxylic acids, and sulfonamides [PDF]

, 2009
SPARC, KOWWIN, and ALOGPS octanol-water partitioning (log K~ow~) and distribution (log D) constants were calculated for all C~1~ through C~8~ and the straight chain C~9~ through C~15~ perfluoroalkyl sulfonic acids (PFSAs) and carboxylic acids (PFCAs ...
Kaya Forest, Sierra Rayne
core   +1 more source

Safety of sulfamethoxazole–trimethoprim for the treatment of bacterial infection in outpatient settings: A systematic review and meta‐analysis with active comparator disproportionality analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Sulfamethoxazole–trimethoprim (SMX‐TMP) is a widely used antibiotic for treating bacterial infections, but its safety in adult outpatients remains understudied. This systematic review and meta‐analysis evaluated the safety profile of SMX‐TMP and identified critical research gaps.
Rebecca Preyra, Lujain Ez Eddin, Fatemeh Ahmadi, Atefeh Jafari, Flory T. Muanda   +4 more
wiley   +1 more source