Results 61 to 70 of about 86,041 (331)

Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Acridine orange (AO) a fluorescent cationic dye used for the management of human musculoskeletal sarcomas, due to its strong tumoricidal action and accumulation in the acidic environment typical of hypoxic tumors, was used for the preparation of a ...
Marco Bragagni, Fabrizio Carta, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran   +4 more
doaj   +1 more source

Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents

Chemistry Central Journal, 2018
BackgroundNitrogen heterocyclic rings and sulfonamides have attracted attention of several researchers.ResultsA series of regioselective imidazole-based mono- and bis-1,4-disubstituted-1,2,3-triazole-sulfonamide conjugates 4a–f and 6a–f were designed and
F. Al-blewi, Meshal A. Almehmadi, M. Aouad, S. Bardaweel, P. Sahu, M. Messali, N. Rezki, E. El Ashry   +7 more
semanticscholar   +1 more source

Evaluation of a Product Intended for Microbiological Control in Animal Production, and Its Combination With Halquinol

Animal Research and One Health, EarlyView.
Activo Liquid and Halquinol inhibit Salmonella and Escherichia coli in culture media. Activo Liquid exhibits bactericidal action, whereas HA is bacteriostatic, and their combination results in positive or indifferent interactions. This combination effectively inhibits E. coli throughout digestion simulation, thus reducing the required concentrations of
Alberto Gonçalves Evangelista, Lucas dos Santos Janotto, Adriana Paula Possamai, Carolina Cini Perry, Francine Lemes Ribeiro, Rafael Canonenco de Araujo, Fernando Bittencourt Luciano   +6 more
wiley   +1 more source

Long‐Term Outcomes of Reduced Intensity Conditioning Hematopoietic Stem Cell Transplantation for Systemic Sclerosis Patients with Impaired Cardiac Function

Arthritis &Rheumatology, Accepted Article.
Objective High intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced SSc. The role of reduced intensity conditioning (RIC) prior to AHSCT in this population remains unclear. We conducted this study to determine the long‐term outcomes of RIC AHSCT in SSc patients with cardiac ...
Yonatan Lean, Carrie Richardson, Anthony Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

Identification and synthesis of metabolites of the new antiglaucoma drug

Research Results in Pharmacology
Introduction: The determination of biotransformation products is an essential part of the preclinical trial of original medicines. These studies have not been conducted before for the new drug 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide.
Alexander L. Khokhlov, Ilya I. Yaichkov, Anton А. Shetnev, Sergey A. Ivanovsky, Mikhail K. Korsakov, Mikhail A. Alexeev, Olga A. Gasilina, Nikita N. Volkhin, Sergey S. Petukhov   +8 more
doaj   +1 more source

(E)-4-Amino-N-(1,2-dihydropyridin-2-ylidene)benzenesulfonamide nitromethane monosolvate

Acta Crystallographica Section E, 2012
In the title solvate, C11H11N3O2S·CH3NO2, the dihedral angle between the benzene ring and the N-containing ring is 85.94 (11)°, and an approximate V shape arises for the sulfonamide molecule.
Mostafa M. Ghorab, Mansour S. Al-Said, Hazem A. Ghabbour, Suchada Chantrapromma, Hoong-Kun Fun   +4 more
doaj   +1 more source

Discovery of Dithioacetal Derivatives Containing Sulfonamide Moiety of Novel Antiviral Agents by TMV Coat Protein as a Potential Target [PDF]

, 2020
Yuyuan Yang, Jian Zhang, Xiangyang Li, Fangcheng He, Rong Wu, Deyu Hu, Baoan Song   +6 more
openalex   +1 more source

Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Hayreddin Gezegen, Oguz Özbek, Meryem Topal, Hatice Şahin, Ümit M. Koçyiğit   +4 more
wiley   +1 more source

NH‐Sulfilimine Synthesis Catalyzed by Nonheme Iron(II) Complex

ChemistryEurope, EarlyView.
Sulfilimines are emerging as valuable functional group in modern medicinal chemistry. Yet, their catalytic preparation is underexplored compared to sulfoximines. Here, the iron‐catalyzed synthesis of 14 examples of unprotected sulfilimines in good yields, under aerobic atmosphere and at room temperature, is described.
Léa Tesson, Jean‐Pierre Mahy, Frédéric Avenier   +2 more
wiley   +1 more source

N-(1-Allyl-1H-indazol-5-yl)-4-methoxybenzenesulfonamide hemihydrate

Acta Crystallographica Section E, 2013
In the title compound, C17H17N3O3.0.5H2O, the indazole system makes a dihedral angle of 46.19 (8)° with the plane through the benzene ring and is nearly perpendicular to the allyl group, as indicated by the dihedral angle of 81.2 (3 ...
Hakima Chicha, El Mostapha Rakib, Detlef Geffken, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source