Results 91 to 100 of about 110,887 (393)
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 A series of organometallic acylhydrazones was prepared, incorporating Re(CO)3, Mn(CO)3 and ferrocenyl moieties, which were subsequently reacted with amino-sulfonamides in order to obtain carbonic anhydrase (CA, EC 4.2.1.1) inhibitors possessing ...
Yosselin Huentupil +5 more
doaj +1 more source
Antibiotics, 2022 Antibiotic distribution and analysis within liquid and solid fractions of manure are highly variable due to each compound’s respective physiochemical properties.
Carlton Poindexter +3 more
doaj +1 more source
Rhodium(II)-catalyzed stereocontrolled synthesis of 2-tetrasubstituted saturated heterocycles from 1-Sulfonyl-1,2,3-triazoles [PDF]
, 2014 Rhodium(II) acetate catalyzes the denitrogenative transformation of 4-substituted 1-sulfonyl-1,2,3-triazoles with pendent allyl and propargyl ethers and thioethers to onium ylides that undergo [2,3]-sigmatropic rearrangement to give 2-tetrasubstituted ...
Boyer, Alistair
core +1 more source
Nature Communications, 2019 The importance of axial chirality in enantioselective synthesis has been widely recognized for decades. The practical access to certain structures such as biaryl amino phenols known as NOBINs in enantiopure form, however, still remains a challenge.
Shenci Lu +7 more
semanticscholar +1 more source
Resistance to trimethoprim and sulfonamides [PDF]
Veterinary Research, 2001 Sulfonamides and trimethoprim have been used for many decades as efficient and inexpensive antibacterial agents for animals and man. Resistance to both has, however, spread extensively and rapidly. This is mainly due to the horizontal spread of resistance genes, expressing drug-insensitive variants of the target enzymes dihydropteroate synthase and ...
openaire +5 more sources
Angewandte Chemie International Edition, Accepted Article.This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley +1 more source
Holographic Gaussian Boson Sampling with Matrix Product States on 3D cQED Processors [PDF]
We introduce quantum circuits for simulations of multi-mode state-vectors on 3D cQED processors, using matrix product state representations. The circuits are demonstrated as applied to simulations of molecular docking based on holographic Gaussian boson sampling, as illustrated for binding of a thiol-containing aryl sulfonamide ligand to the tumor ...
arxiv +1 more source
An assessment of organic solvent based equilibrium partitioning methods for predicting the bioconcentration behavior of perfluorinated sulfonic acids, carboxylic acids, and sulfonamides [PDF]
, 2009 SPARC, KOWWIN, and ALOGPS octanol-water partitioning (log K~ow~) and distribution (log D) constants were calculated for all C~1~ through C~8~ and the straight chain C~9~ through C~15~ perfluoroalkyl sulfonic acids (PFSAs) and carboxylic acids (PFCAs ...
Kaya Forest, Sierra Rayne
core +1 more source
Journal of the American Chemical Society, 2019 Both arylsulfonyl and alkylsulfonyl azides can be effectively activated by the cobalt(II) complexes of D2-symmetric chiral amidoporphyrins for enantioselective radical 1,5-C-H amination to stereoselectively construct 5-membered cyclic sulfonamides.
Yang Hu +11 more
semanticscholar +1 more source
Angewandte Chemie International Edition, Accepted Article.Sulfonyl fluorides have gained significant importance due to their classification as a click reaction and therefore have seen increased use in drug discovery and biochemistry. Their use, however, is complicated by the methods by which they are synthesized and their general synthetic instability.
Twinkle I Patel +4 more
wiley +1 more source