Results 161 to 170 of about 110,887 (393)

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

ChemMedChem, EarlyView.
InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet, Laurent Maveyraud, David Rengel, Valérie Guillet, Gabriel Publicola, Frédéric Rodriguez, Christian Lherbet, Lionel Mourey   +7 more
wiley   +1 more source

The Mechanism of Resistance to Sulfonamides [PDF]

, 1944
M. G. Sevag, Morris N. Green
openalex   +3 more sources

Folinsäure-Synthese und antibakterielle Wirkung der Sulfonamide [PDF]

, 1947
Rudolf Tschesche, Klaus Soehring, Käthi Härder   +2 more
openalex   +1 more source

Conjugated sulfonamides as a class of organic lithium-ion positive electrodes

Nature Materials, 2020
Jiande Wang, A. E. Lakraychi, Xuelian Liu, Louis Sieuw, C. Morari, P. Poizot, A. Vlad   +6 more
semanticscholar   +1 more source

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, EarlyView.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

Beziehungen zwischen Sulfonamiden und Folinsäure; durch Sulfonamide bedingtes Folinsäurebedürfnis von Bakterien [PDF]

, 1949
E. F. Möller, Friedrich Weygand, A. Wacker   +2 more
openalex   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, EarlyView.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Biologic Changes in Sulfonamide-resistant Mycobacterium ranae [PDF]

, 1946
Dirán Yegian, Vera Budd, Gardner Middlebrook   +2 more
openalex   +1 more source

Novel para‐phenylenediamine‐based derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An in vitro preliminary characterization

ChemMedChem, Accepted Article.
ROR1 kinase is an underexplored promising target for the development of novel anticancer drugs, being strongly expressed in several cancer cell lines, but poorly in non‐tumor cells. This property, together with the scarce number of molecules effective against ROR1, led us to design and develop a research program aimed to the discovery of new chemical ...
Gerardina Smaldone, Maria Rosaria Miranda, Francesca Di Matteo, Valeria Napolitano, Michela Aliberti, Simona Musella, Veronica Di Sarno, Gianluigi Lauro, Giuseppe Bifulco, Giacomo Pepe, Giovanna Aquino, Mario Felice Tecce, Isabel Maria Gomez-Monterrey, Pietro Campiglia, Carmine Ostacolo, Alessia Bertamino, Vincenzo Vestuto, Tania CIAGLIA   +17 more
wiley   +1 more source

NOTIZEN: Zur Frage des antibakteriellen Wirkungsmechanismus der Sulfonamide (3. Mitt.) [PDF]

, 1948
Rudolf Tschesche, Werner Loop, Klaus Soehring   +2 more
openalex   +1 more source