Results 11 to 20 of about 113,455 (289)
Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation [PDF]
Journal of Chemistry, 2015 New amidine and benzene sulfonamide derivatives were developed and structures of the new products were confirmed by elemental and spectral analysis (FT-IR, ESI-MS, 1HNMR, and 13CNMR).
Muhammad Abdul Qadir +4 more
doaj +3 more sources
Pharmacy, 2019 As one of the earliest developed antimicrobial classes, sulfonamides remain important therapeutic options for the empiric and definitive treatment of various infectious diseases. In the general population, approximately 3–8% of patients are reported to experience a sulfonamide allergy. Sulfonamide allergies can result in various physical manifestations;
Amber Giles +3 more
openaire +3 more sources
Deconstructing Protein Binding of Sulfonamides and Sulfonamide Analogues
JACS Au, 2023 Sulfonamides are one of the most important pharmacophores in medicinal chemistry and sulfonamide analogs have gained substantial interest in recent years. However, the protein interactions of sulfonamides and especially of their analogs are underexplored.
Patrick L. Purder +9 more
openaire +3 more sources
PLoS ONE, 2020 BackgroundSulfonamides are widely used to treat infectious diseases during pregnancy. However, the safety of maternal exposure to sulfonamides is controversial.
Peixuan Li +3 more
doaj +1 more source
Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs. [PDF]
PLoS Pathogens, 2016 The methylfolate trap, a metabolic blockage associated with anemia, neural tube defects, Alzheimer's dementia, cardiovascular diseases, and cancer, was discovered in the 1960s, linking the metabolism of folate, vitamin B12, methionine and homocysteine ...
Marissa B Guzzo +14 more
doaj +1 more source
Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N -Diethyl-Substituted AmidoMoieties [PDF]
, 2012 Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities.
Ajani, Olayinka O. +4 more
core +5 more sources
Frontiers in Pharmacology, 2021 The synthesis and antioxidant, antinociceptive and antiedematogenic activities of sulfonamides derived from carvacrol—a druglike natural product—are reported.
Aldo S. de Oliveira +11 more
doaj +1 more source
Site-Selective C–H Functionalization–Sulfination Sequence to Access Aryl Sulfonamides
Organic Letters, 2020 Aryl sulfinates are precursors to a diverse number of sulfonyl-derived arenes, which are common motifs in pharmaceuticals and agrochemicals. Here, we report a site-selective two-step C–H sulfination sequence via aryl sulfonium salts to access aryl ...
E. Alvarez +3 more
semanticscholar +1 more source
Synthesis and Antibacterial Activity of N,N-Diethylamide Bearing Benzenesulfonamide Derivatives [PDF]
, 2013 Sulfonamides are known to represent a class of medicinally important compounds which are extensively used as antibacterial agents. Hence, a series of new N,N-diethyl amide bearing sulfonamides (2a-k) were synthesized via amidation of easily prepared ...
Ajani, Olayinka O. +4 more
core +1 more source
Journal of the American Chemical Society, 2020 An enantioselective, radical-based method for the intramolecular hydroamination of alkenes with sulfonamides is reported. These reactions are proposed to proceed via N-centered radicals formed by proton-coupled electron transfer (PCET) activation of ...
Casey B. Roos +3 more
semanticscholar +1 more source