Results 21 to 30 of about 38,324 (259)

Socio-historical analysis of the social importance of pharmacovigilance

Frontiers in Sociology, 2022
Pharmacovigilance is a scientific discipline that has changed a lot in recent years and is of great social importance. The case of the so-called sulfonamide elixir showed society the importance of this discipline.
Juan R. Coca, Raquel Coca-Asensio, Gema Esteban Bueno   +2 more
doaj   +1 more source

Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs. [PDF]

PLoS Pathogens, 2016
The methylfolate trap, a metabolic blockage associated with anemia, neural tube defects, Alzheimer's dementia, cardiovascular diseases, and cancer, was discovered in the 1960s, linking the metabolism of folate, vitamin B12, methionine and homocysteine ...
Marissa B Guzzo, Hoa T Nguyen, Thanh H Pham, Monika Wyszczelska-Rokiel, Hieronim Jakubowski, Kerstin A Wolff, Sam Ogwang, Joseph L Timpona, Soumya Gogula, Michael R Jacobs, Markus Ruetz, Bernhard Kräutler, Donald W Jacobsen, Guo-Fang Zhang, Liem Nguyen   +14 more
doaj   +1 more source

Synthesis, Structural Elucidation, and Biological Potential of Novel Sulfonamide Drugs

Bioscientific Review, 2022
Sulfonamides are anti-microbial and anti-inflammatory agents used widely for the treatment of infections. The current research dealt with the synthesis of four sulfonamides formed by the reaction of p-toluenesulfonyl chloride with 4-amino phenyl acetic ...
Shabbir Hussain, Shakila Riaz, Hajira Rehman, Muhammad Shahid, Syed Mustansar Abbas   +4 more
doaj   +1 more source

Enzymatic Transformation and Bonding of Sulfonamide Antibiotics to Model Humic Substances

Journal of Chemistry, 2015
Sulfonamides are consumed as pharmaceutical antibiotics and reach agricultural soils with excreta used as fertilizer. Subsequently, nonextractable residues rapidly form in soil, which has been researched in a couple of studies.
J. Schwarz, H. Knicker, G. E. Schaumann, S. Thiele-Bruhn   +3 more
doaj   +1 more source

New Cu⁺² Complexes with N-Sulfonamide Ligands: Potential Antitumor, Antibacterial, and Antioxidant Agents

Molecules, 2022
Nowadays, the discovery of a new non-toxic metal complex with biological activity represents a very active area of research. Two Cu+2 complexes, [Cu(L1)2(H2O)3] (C1) (HL1= N-(5-(4-methylphenyl)-[1,3,4]–thiadiazole–2-yl)-naphtalenesulfonamide) and [Cu(L2 ...
Adriana Corina Hangan, Alexandru Turza, Roxana Liana Lucaciu, Bogdan Sevastre, Emőke Páll, Luminița Simona Oprean, Gheorghe Borodi   +6 more
doaj   +1 more source

Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides as Novel Potential Anticancer Agents: Cytotoxic and Genotoxic Activities In Vitro

Molecules, 2022
In this paper, we present for the first time the evaluation of cytotoxicity and genotoxicity of de novo synthesized pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides MM129, MM130, and MM131 in human tumor cell lines: HeLa, HCT 116, PC-3, and ...
Karol Bukowski, Beata Marciniak, Mateusz Kciuk, Mariusz Mojzych, Renata Kontek   +4 more
doaj   +1 more source

Sulfonamides and trimethoprim [PDF]

Expert Review of Anti-infective Therapy, 2009
Sulfonamides and trimethoprim are inexpensive and effective antibacterial drugs that have been used extensively. The use of sulfonamides for systemic use has, however, decreased dramatically for several years, mainly because of resistance development in pathogenic bacteria and allergic side effects. Also the clinical efficiency of trimethoprim has been
openaire   +2 more sources

Automated Online Solid-Phase Extraction Coupled with Sequential Injection-HPLC-EC System for the Determination of Sulfonamides in Shrimp

International Journal of Electrochemistry, 2012
The use of fully automated online solid-phase extraction (SPE) coupled with sequential injection analysis, high-performance liquid chromatography (HPLC), and electrochemical detection (EC) for the separation and determination of sulfonamides has been ...
Pimkwan Chantarateepra, Weena Siangproh, Shoji Motomizu, Orawon Chailapakul   +3 more
doaj   +1 more source

Exploring the potential of propanamide-sulfonamide based drug conjugates as dual inhibitors of urease and cyclooxygenase-2: biological and their in silico studies

Frontiers in Chemistry, 2023
Derivative synthesis has been a crucial method for altering the effects of already-approved medications, especially to lessen adverse effects and enhance results.
Saghir Ahmad, Saghir Ahmad, Muhammad Abdul Qadir, Mahmood Ahmed, Muhammad Imran, Numan Yousaf, Tanveer A. Wani, Seema Zargar, Ijaz Ali, Muhammad Muddassar   +9 more
doaj   +1 more source

Real-life data on the efficacy and safety of ombitasvir/paritaprevir/ritonavir + dasabuvir +ribavirin in the patients with genotype 1 chronic hepatitis C virus infection in Serbia [PDF]

Vojnosanitetski Pregled, 2019
Background/Aim. The era of direct-acting antiviral (DAA) regimen in the treatment of chronic hepatitis C virus (HCV) started in 2011. The aim of this study was to assess the antiviral efficacy and safety of DAA regimen, ombitasvir (OBV)/paritaprevir (PTV)
Simonović-Babić Jasmina, Bojović Ksenija, Fabri Milotka, Cvejić Tatjana, Svorcan Petar, Nožić Darko, Jovanović Maja, Škrbić Ranko, Stojiljković Miloš P., Mijailović Željko   +9 more
doaj   +1 more source