Results 11 to 20 of about 37,484 (257)
Socio-historical analysis of the social importance of pharmacovigilance
Frontiers in Sociology, 2022 Pharmacovigilance is a scientific discipline that has changed a lot in recent years and is of great social importance. The case of the so-called sulfonamide elixir showed society the importance of this discipline.
Juan R. Coca +2 more
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Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs. [PDF]
PLoS Pathogens, 2016 The methylfolate trap, a metabolic blockage associated with anemia, neural tube defects, Alzheimer's dementia, cardiovascular diseases, and cancer, was discovered in the 1960s, linking the metabolism of folate, vitamin B12, methionine and homocysteine ...
Marissa B Guzzo +14 more
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Synthesis, Structural Elucidation, and Biological Potential of Novel Sulfonamide Drugs
Bioscientific Review, 2022 Sulfonamides are anti-microbial and anti-inflammatory agents used widely for the treatment of infections. The current research dealt with the synthesis of four sulfonamides formed by the reaction of p-toluenesulfonyl chloride with 4-amino phenyl acetic ...
Shabbir Hussain +4 more
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Sulfonamides and trimethoprim [PDF]
Expert Review of Anti-infective Therapy, 2009 Sulfonamides and trimethoprim are inexpensive and effective antibacterial drugs that have been used extensively. The use of sulfonamides for systemic use has, however, decreased dramatically for several years, mainly because of resistance development in pathogenic bacteria and allergic side effects. Also the clinical efficiency of trimethoprim has been
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Enzymatic Transformation and Bonding of Sulfonamide Antibiotics to Model Humic Substances
Journal of Chemistry, 2015 Sulfonamides are consumed as pharmaceutical antibiotics and reach agricultural soils with excreta used as fertilizer. Subsequently, nonextractable residues rapidly form in soil, which has been researched in a couple of studies.
J. Schwarz +3 more
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Molecules, 2022 Nowadays, the discovery of a new non-toxic metal complex with biological activity represents a very active area of research. Two Cu+2 complexes, [Cu(L1)2(H2O)3] (C1) (HL1= N-(5-(4-methylphenyl)-[1,3,4]–thiadiazole–2-yl)-naphtalenesulfonamide) and [Cu(L2 ...
Adriana Corina Hangan +6 more
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Pharmacy, 2019 As one of the earliest developed antimicrobial classes, sulfonamides remain important therapeutic options for the empiric and definitive treatment of various infectious diseases. In the general population, approximately 3–8% of patients are reported to experience a sulfonamide allergy. Sulfonamide allergies can result in various physical manifestations;
Amber Giles +3 more
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Molecules, 2022 In this paper, we present for the first time the evaluation of cytotoxicity and genotoxicity of de novo synthesized pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides MM129, MM130, and MM131 in human tumor cell lines: HeLa, HCT 116, PC-3, and ...
Karol Bukowski +4 more
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International Journal of Electrochemistry, 2012 The use of fully automated online solid-phase extraction (SPE) coupled with sequential injection analysis, high-performance liquid chromatography (HPLC), and electrochemical detection (EC) for the separation and determination of sulfonamides has been ...
Pimkwan Chantarateepra +3 more
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Frontiers in Chemistry, 2023 Derivative synthesis has been a crucial method for altering the effects of already-approved medications, especially to lessen adverse effects and enhance results.
Saghir Ahmad +9 more
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