Results 311 to 320 of about 110,887 (393)

The role of per‐ and polyfluoroalkyl substances in cognitive impairment and dementia

Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract Per‐ and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants. The neurotoxic and cardiometabolic effects of PFAS are well documented, leading to the hypothesis that exposure increases dementia risk. However, empirical data on PFAS in relation to cognitive impairment and dementia are weak, limited, and inconsistent ...
Hannah Gardener, Bonnie Levin, Kurunthachalam Kannan, Tatjana Rundek   +3 more
wiley   +1 more source

Exploring the Inhibition of <i>Toxoplasma gondii</i> α-Carbonic Anhydrase by Sulfonamides: Insights into Potential Drug Targeting. [PDF]

Int J Mol Sci
Giovannuzzi S, De Luca V, Capasso C, Supuran CT.   +3 more
europepmc   +1 more source

pH‐Directed Capture‐SELEX for Nanomolar Affinity Aptamers for Kanamycin Detection

Analysis &Sensing, Volume 5, Issue 3, May 2025.
Considering the four pKa values of kanamycin A being all close to 7, two parallel SELEX experiments were carried out at pH 6 and 8. The pH 6 selection yielded a kanamycin aptamer with nanomolar affinity, which was used for fluorescent biosensor development.
Yichen Zhao, Juewen Liu
wiley   +1 more source

Palladium‐Catalyzed [3+2] Cycloadditions of Alkylidenecyclopropanes to Imines: A Direct Approach to Pyrrolidine Scaffolds

ChemistryEurope, Volume 3, Issue 3, May 2025.
Pd‐catalyzed annulations of ACPs with different C=N partners in both inter‐ and intramolecular ways are described. The methods provide access to pyrrolidines and pyrrolidine‐fused polycyclic systems, featuring β‐exo‐methylene moieties. Preliminary enantioselective variant has been shown by using a chiral phosphoramidite ligand and DFT studies shed ...
Ricardo Rodiño, Felipe Verdugo, José L. Mascareñas, Fernando López   +3 more
wiley   +1 more source

Occurrence of antibiotics and antibiotic resistance genes at various stages of different aquaculture modes surrounding Tai Lake, China. [PDF]

Front Microbiol
Wu C, Ye H, Xu M, Zhao X, Zhao X, Li L, Li M, Wei Y, Li Y, Hu B.   +9 more
europepmc   +1 more source

Skeletal Rearrangements of Amides via Breaking Inert Bonds

Chemistry – A European Journal, Volume 31, Issue 25, May 5, 2025.
This review highlights advances in amide skeletal rearrangement reactions over the past two decades, categorized by the initial bond cleavages: C─N bond cleavage, C─C bond cleavage, and C═O bond activation. It summarizes emerging strategies, mechanistic insights, and synthetic applications, providing a focused perspective on recent developments in this
Rui Zhang, Guangbin Dong
wiley   +1 more source

Effect of preconception antibiotics exposure on female reproductive health and pregnancy outcomes: a systematic review and meta-analysis. [PDF]

EClinicalMedicine
Alemu BK, Wang CC, Li L, Zhu Z, Li Q, Wang Y.   +5 more
europepmc   +1 more source

Continuous Titration Based Method for Rapid In‐Solution Analysis of Non‐Covalent Interactions

Chemistry–Methods, Volume 5, Issue 5, May 2025.
This work presents cSPRING, which combines Taylor dispersion with ratiometric fluorescence detection to measure binding affinities (Kd) in a single experiment. This in‐solution method reduces sample preparation time 8‐fold, requires only nanograms of protein, and provides results in under a minute, demonstrating efficiency for screening protein‐small ...
Philipp Willmer, Adam C. Hundahl, Rodolphe Marie, Henrik Jensen   +3 more
wiley   +1 more source

Sulfilimines: An Underexplored Bioisostere for Drug Design? [PDF]

J Med Chem
Arvidsson PI.
europepmc   +1 more source

Augmenting the Anti‐Leukemic Activity of the BCL‐2 Inhibitor Venetoclax Through Its Transformation Into Polypharmacologic Dual BCL‐2/HDAC1 and Dual BCL‐2/HDAC6 Inhibitors

Drug Development Research, Volume 86, Issue 3, May 2025.
ABSTRACT Motivated by the anti‐leukemic synergy between histone deacetylase (HDAC) inhibitors and the FDA‐approved BCL‐2 inhibitor venetoclax, coupled with our interests in polypharmacology, we sought to bolster the anti‐leukemic efficacy of the clinical drug by grafting HDAC1‐selective or HDAC6‐selective inhibitor motifs onto a solvent‐accessible ...
Alexandria M. Chan, Christian Eberly, Brandon Drennen, Christopher C. Goodis, Zoe Wuyts, Curt I. Civin, Steven Fletcher   +6 more
wiley   +1 more source