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Development of Efficient Covalent Inactivators of a Fungal Aspartate Semialdehyde Dehydrogenase

open access: yesDrug Development Research, Volume 86, Issue 3, May 2025.
ABSTRACT Aspartate semialdehyde dehydrogenase (ASADH) catalyzes the second step in the fungal pathway towards the synthesis of threonine, isoleucine, and methionine, and it has been identified as a viable target for antifungal drug development. Our previous work produced a group of vinyl sulfones that function as irreversible covalent inactivators of ...
Samantha N. Friday   +14 more
wiley   +1 more source

Emerging Trends in Antimicrobial Resistance in Polar Aquatic Ecosystems. [PDF]

open access: yesAntibiotics (Basel)
Bisaccia M   +3 more
europepmc   +1 more source

Multidrug-Resistant Proteus mirabilis and Other Gram-Negative Species Isolated from Native Egyptian Chicken Carcasses. [PDF]

open access: yesTrop Med Infect Dis
El-Saeed BA   +7 more
europepmc   +1 more source

Correction: Fluorinated aromatic PCBTF and 6:2 diPAP in bridge and traffic paints.

open access: yesEnviron Sci Process Impacts
Kim-Fu ML   +5 more
europepmc   +1 more source

Risk assessment of antibiotic residues and resistance profile of E. coli in typical rivers of Sichuan, China. [PDF]

open access: yesPLoS One
Sha J   +11 more
europepmc   +1 more source

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