Results 31 to 40 of about 83,744 (322)

Sulfonamides and trimethoprim [PDF]

Expert Review of Anti-infective Therapy, 2009
Sulfonamides and trimethoprim are inexpensive and effective antibacterial drugs that have been used extensively. The use of sulfonamides for systemic use has, however, decreased dramatically for several years, mainly because of resistance development in pathogenic bacteria and allergic side effects. Also the clinical efficiency of trimethoprim has been
openaire   +2 more sources

Síntese de amidas e sulfonamidas de beta-D-galactopiranosilamina e beta-lactosilamina e avaliação de suas interações com lectinas de Erythrina cristagalli e de Ricinus communis Synthesis of amides and sulfonamides of beta-D- galactopyranosylamine and beta-lactosylamine and evaluation of their interactions with the lectins from Erythrina cristagalli and Ricinus communis

Química Nova, 2007
We report herein the synthesis of some beta-D-galactopyranosylamine and beta-lactosylamine amides and sulfonamides. The interactions of these compounds with lectins from the seeds of Erythrina cristagalli (LEC) and Ricinus communis (RCA120) were ...
Anna Paola Butera, José Dias de Souza Filho, Diogo Teixeira Carvalho, Rute Cunha Figueiredo, Luiz Carlos Alves de Faria, Maria Angélica Nunes, Maria Auxiliadora Fontes Prado, Ricardo José Alves, Milton Hércules Guerra de Andrade, Karina Taciana Santos Silva   +9 more
doaj   +1 more source

Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation

Journal of Chemistry, 2015
New amidine and benzene sulfonamide derivatives were developed and structures of the new products were confirmed by elemental and spectral analysis (FT-IR, ESI-MS, 1HNMR, and 13CNMR).
Muhammad Abdul Qadir, Mahmood Ahmed, Hina Aslam, Sadia Waseem, Muhammad Imtiaz Shafiq   +4 more
doaj   +1 more source

Reductive cleavage of sulfones and sulfonamides by neutral organic super electron-donor (S.E.D.) reagent [PDF]

, 2007
The sulfonyl group finds extensive applications in organic and medicinal chemistry both in sulfonamides, popular as robust protecting groups for amines, and in sulfones.
Miclo, Yves, Murphy, John A., Schoenebeck, Fransziska, Tuttle, Tell, Uenoyama, Yoshitaka, Zhou, Sheng-ze   +5 more
core   +1 more source

Ecofriendly Synthesis in Aqueous Medium: An Expeditious Approach to New N,N-Diethyl Amide Bearing Benzenemethanesulfonamides [PDF]

, 2013
An highly expeditious synthetic approach for the synthesis of benzenemethanesulfonamides (1a-k) and their new corresponding N,N-diethyl substituted amido moieties (2a-k) has been achieved in aqueous medium at room tem-perature. The reaction condition was
Ajani, O. O., Echeme, J. O., Familoni, O. B., Wu, F.   +3 more
core   +1 more source

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

Socio-historical analysis of the social importance of pharmacovigilance

Frontiers in Sociology, 2022
Pharmacovigilance is a scientific discipline that has changed a lot in recent years and is of great social importance. The case of the so-called sulfonamide elixir showed society the importance of this discipline.
Juan R. Coca, Raquel Coca-Asensio, Gema Esteban Bueno   +2 more
doaj   +1 more source

Predictive, Data‐Driven Design of Red‐Light Photoredox Catalysts for C─Heteroatom Bond Formation

Angewandte Chemie, EarlyView.
From redox numbers to red light: Donor oxidation and core reduction potentials predict E0‐0 in cyanoarene dyes, guiding selection of an efficient red‐light catalyst, 4MeODPATPN (PC13). Under 620 nm light, PC13 facilitates Ni‐catalyzed C─heteroatom cross‐couplings (C─N, C─O, C─S) with high functional‐group tolerance and reduced hydrodehalogenation ...
Amir Gizatullin, Tingting Yuan, Sascha Grotjahn, Luigi Cavallo, Burkhard König, Chen Zhu, Magnus Rueping   +6 more
wiley   +2 more sources

Gold-catalyzed intermolecular hydroamination of allenes with sulfonamides

Beilstein Journal of Organic Chemistry, 2013
A co-catalyst of (PPh3)AuCl/AgOTf for the intermolecular hydroamination of allenes with sulfonamides is shown. The reaction proceeded smoothly under mild conditions for differently substituted allenes giving N-allylic sulfonamides in good yields with ...
Chen Zhang, Shao-Qiao Zhang, Hua-Jun Cai, Dong-Mei Cui   +3 more
doaj   +1 more source

Special Issue: Sulfonamides

Molecules, 2017
The sulfonamides and their structurally related derivatives, such as the sulfamates and sulfamides, possess the general formula A-SO2NHR, in which the functional group is either directly bound to an aromatic, heterocyclic, aliphatic, or sugar scaffold ...
Claudiu T. Supuran
doaj   +1 more source