Metal‐Free Electrochemical Synthesis of Sulfonamides Directly from (Hetero)arenes, SO2, and Amines
Angewandte Chemie, 2020 Sulfonamides are among the most important chemical motifs in pharmaceuticals and agrochemicals. However, there is no methodology to directly introduce the sulfonamide group to a non‐prefunctionalized aromatic compound.
Stephan P. Blum +4 more
semanticscholar +1 more source
A remote hypertension management program clinical algorithm
Clinical Cardiology, Volume 45, Issue 12, Page 1147-1162, December 2022., 2022 Abstract Introduction Hypertension is the leading risk factor for death, affecting over one billion people worldwide, yet control rates are poor and stagnant. We developed a remote hypertension management program that leverages digitally transmitted home blood pressure (BP) measurements, algorithmic care pathways, and patient–navigator communications ...
Hunter Nichols +3 more
wiley +1 more source
Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators [PDF]
, 2016 This Letter was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Scottish Universities Life Sciences Alliance (SULSA) in 2011Peer ...
Abdelrahman, Mostafa Hamed +4 more
core +1 more source
Gold-catalyzed intermolecular hydroamination of allenes with sulfonamides
Beilstein Journal of Organic Chemistry, 2013 A co-catalyst of (PPh3)AuCl/AgOTf for the intermolecular hydroamination of allenes with sulfonamides is shown. The reaction proceeded smoothly under mild conditions for differently substituted allenes giving N-allylic sulfonamides in good yields with ...
Chen Zhang +3 more
doaj +1 more source
Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance [PDF]
, 2004 Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis.
Atzori, C +6 more
core +2 more sources
Synthesis of Sulfonyl Fluorides from Sulfonamides
Annalen der Pharmacie, 2020 A simple and practical synthesis of sulfonyl fluorides from sulfonamides is reported. The method capitalizes on the formation of the sulfonyl chloride by virtue of the reaction of Pyry-BF4 and MgCl2, and subsequent in situ conversion to the more robust ...
Marina Pérez-Palau, Josep Cornella
semanticscholar +1 more source
Occurrence and dissipation of the antibiotics sulfamethoxazole, sulfadiazine, trimethoprim, and enrofloxacin in the Mekong Delta, Vietnam [PDF]
, 2015 The Mekong Delta in Vietnam has seen a rapid development and intensification of aquaculture in the last decades, with a corresponding widespread use of antibiotics.
Amelung, Wulf +6 more
core +2 more sources
Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release [PDF]
, 2015 Effective and controlled drug delivery systems with on-demand release and targeting abilities have received enormous attention for biomedical applications. Here, we describe a novel enzyme-based cap system for mesoporous silica nanoparticles (MSNs) that is directly combined with a targeting ligand via bio-orthogonal click chemistry.
arxiv +1 more source
Synthesis of Novel Aryl(heteroaryl)sulfonyl Ureas of Possible Biological Interest
Molecules, 2010 The course of reaction of aryl and heteroaryl sulfonamides with diphenylcarbonate (DPC) and 4-dimethylaminopyridine (DMAP) was found to depend on the pKa of the sulfonamide used.
Maria Gdaniec +8 more
doaj +1 more source
Direct Copper-Catalyzed Three-Component Synthesis of Sulfonamides.
Journal of the American Chemical Society, 2018 First introduced into medicines in the 1930s, the sulfonamide functional group continues to be present in a wide range of contemporary pharmaceuticals and agrochemicals.
Yiding Chen +3 more
semanticscholar +1 more source