Results 11 to 20 of about 27,055 (203)

Effect of genetic polymorphisms on the development of secondary failure to sulfonylurea in Egyptian patients with type 2 diabetes

Therapeutic Advances in Endocrinology and Metabolism, 2011
Objective: This study investigated the possibility that genetic factors, such as polymorphism of K inward rectifier subunit (Kir6.2), E23K, and Arg 972 polymorphism of insulin receptor substrate-1 (IRS-1), may predispose patients to sulfonylurea failure.
Alaa E. El-sisi, Sahar K. Hegazy, Shereen S. Metwally, Alaa M. Wafa, Naglaa A. Dawood   +4 more
doaj   +2 more sources

Risk of New-Onset Prostate Cancer for Metformin Versus Sulfonylurea Use in Type 2 Diabetes Mellitus: A Propensity Score-Matched Study [PDF]

, 2022
The aim of this study was to compare the risks of new-onset prostate cancer between metformin and sulfonylurea users with type 2 diabetes mellitus (T2DM).
Liu, Xuejin, Hui, Kyle, Liu, Tong, Wai, Abraham Ka Chung, Lee, Teddy Tai Loy, Lee, Sharen, Zhou, Jiandong, Chan, Jeffrey Shi Kai, Tse, Gary, Lee, Yan Hiu Athena, Wong, Wing Tak, Zhang, Qingpeng, Ng, Kenrick, Dee, Edward Christopher, Hui, Jeremy Man Ho   +14 more
core   +2 more sources

Cognitive Function in Type 2 Diabetes Mellitus Patients Taking Metformin and Metformin-Sulfonylurea [PDF]

, 2022
The most prescribed antidiabetic drugs in Indonesian primary health care are metformin or a combination of metformin and sulfonylurea. Studies on metformin have shown various impacts on cognitive decline in patients with type 2 diabetes mellitus, whereas
Sauriasari, Rani, Rachman, Abu, Syafhan, Nadia Farhanah, Prawiroharjo, Pukovisa, Risni, Hindun Wilda   +4 more
core   +17 more sources

Adsorption of nicosulfuron herbicide in the agricultural soils of Bosnia and Herzegovina

Plant, Soil and Environment, 2020
In this study, the sorption characteristics of nicosulfuron herbicide in soils from different agricultural regions of Bosnia and Herzegovina, as well as factors influencing the sorption process, were evaluated.
Amer Sunulahpašić, Siniša Mitrić, Dragana Šunjka, Mirjana Žabić, Tihomir Predić, Milan Šipka, Luka Rodić   +6 more
doaj   +1 more source

Dynamics of total volume of pancreatic α‐ and β ‐cells under the influence sulfonylureas and their combination with dipeptidyl peptidase‐4 inhibitors

Endocrinology, Diabetes & Metabolism, 2021
Objective Sulfonylureas and dipeptidyl peptidase‐4 inhibitors have a multidirectional effect on pancreatic cells. We aimed to evaluate the effects of these drugs on β‐ and α‐cells in rats aged 12 months with type 2 diabetes mellitus when administered in ...
Tuchina Taisiia Pavlovna, Skotnikova Kseniia Petrovna, Vtorushina Anna Anatolievna, Uskov Ivan Sergeyevich, Rogoza Olga Vladimirovna, Grozov Roman Viktorovich, Babenko Alina Yurievna, Galagudza Mikhail Mikhailovich   +7 more
doaj   +1 more source

Identification of SNP rs1799854 ABCC8 gene and blood glucose levels in patients with type 2 diabetes mellitus at Moewardi hospital Surakarta Solo [PDF]

Pharmaciana, 2021
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by high blood glucose levels due to impaired insulin secretion or insulin resistance. Polymorphisms in the ABCC8 gene rs1799854 are widely found to have an association with T2DM,
Mardiana Puji Lestari, Imaniar Noor Faridah, Rita Maliza, Haafizah Dania, Melinda Widianingrum, Dyah Aryani Perwitasari   +5 more
doaj   +1 more source

Should sulfonylurea be discontinued or maintained at the lowest dose when starting ipragliflozin? A multicenter observational study in Japanese patients with type 2 diabetes

Journal of Diabetes Investigation, 2019
Aims/Introduction We investigated the difference in efficacy and safety between discontinuation and maintaining of sulfonylurea when adding a sodium–glucose cotransporter 2 inhibitor.
Kiyohiko Takahashi, Kyu Yong Cho, Akinobu Nakamura, Aika Miya, Arina Miyoshi, Chiho Yamamoto, Hiroshi Nomoto, Hirokatsu Niwa, Kiyohito Takahashi, Naoki Manda, Yoshio Kurihara, Shin Aoki, Yoichi M Ito, Tatsuya Atsumi, Hideaki Miyoshi   +14 more
doaj   +1 more source

Unintentional sulfonylurea toxicity due to a drug–drug interaction: a case report

BMC Research Notes, 2018
Background Sulfonylureas are widely used for type 2 diabetes mellitus, but these medications carry a risk of hypoglycemia. Drug–drug interactions that inhibit sulfonylurea metabolism and thus increase systemic exposure can cause unintentional ...
Keith Gunaratne, Emily Austin, Peter E. Wu   +2 more
doaj   +1 more source

Reasoned opinion on the review of the existing maximum residue levels (MRLs) for mesosulfuron according to Article 12 of Regulation (EC) No 396/2005 [PDF]

EFSA Journal, 2012
According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) has reviewed the Maximum Residue Levels (MRLs) currently established at European level for the pesticide active substance mesosulfuron.
European Food Safety Authority
doaj   +1 more source

Sulfonylurea-insensitive permanent neonatal diabetes caused by a severe gain-of-function Tyr330His substitution in Kir6.2

, 2022
Background/aims: Mutations in KCNJ11, the gene encoding the Kir6.2 subunit of pancreatic and neuronal KATP channels, are associated with a spectrum of neonatal diabetes diseases. Methods: Variant screening was used to identify cause of neonatal diabetes,
Perri, Alessandro, Nichols, Colin G, Mucciolo, Mafalda, Roeglin, Jacob, McClenaghan, Conor, Cianfarani, Stefano, Gao, Jian, Vento, Giovanni, Barbetti, Fabrizio, Schiaffini, Riccardo, De Rose, Domenico Umberto, Rapini, Novella, Tiberi, Eloisa, Deodati, Annalisa, Bizzarri, Carla, Deodati, A, Schiaffini, R, Mucciolo, M, Roeglin, J, Rapini, N, McClenaghan, C, Bizzarri, C, De, Rose DU, Tiberi, E, Gao, J, Jian Gao, Giovanni Vento, Colin G. Nichols, Eloisa Tiberi, Alessandro Perri, Annalisa Deodati, Riccardo Schiaffini, Domenico Umberto De Rose, Carla Bizzarri, Novella Rapini, Mafalda Mucciolo, Jacob Roeglin, Fabrizio Barbetti, Stefano Cianfarani, Conor McClenaghan   +39 more
core   +1 more source