Results 121 to 130 of about 1,586,237 (267)

Treatment progression in sulfonylurea and dipeptidyl peptidase-4-inhibitor cohorts of type 2 diabetes patients on metformin

, 2016
Xiaomei Peng, Dingfeng Jiang, Dongju Liu, Oralee J Varnado, Jay P Bae Eli Lilly and Company, Global Patient Outcomes and Real World Evidence, Indianapolis, IN, USA Background: Metformin is an oral antidiabetic drug (OAD) widely used as first-line ...
Peng X, Varnado OJ, Bae JP, Jiang D, Liu D   +4 more
core  

SGLT2i use and fracture risk compared with DPP4i in patients with T2DM

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Introduction The association between sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) use and fracture risk remains inconclusive. Most previous studies have focused on treatment‐naïve patients, despite many patients in routine clinical practice initiating SGLT2i therapy after prior dipeptidyl peptidase‐4 inhibitor (DPP4i) use.
Sung‐Yen Lin, Shih‐Hao Huang, Ching‐Han Chiang, Cheng‐Jung Ho, Chung‐Hwan Chen, Li‐Nien Chien   +5 more
wiley   +1 more source

Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency

Life Science Alliance
The NLRP3 inflammasome drives various diseases. Here, we describe novel potent and selective NLRP3-targeted inhibitors to bolster pharmacological studies and development of NLRP3-targeted therapies.
Lieselotte Vande Walle, Madhukar Said, Oonagh Paerewijck, Arinna Bertoni, Marco Gattorno, Bruno Linclau, Mohamed Lamkanfi   +6 more
doaj   +1 more source

The Generics Revolution and the New Economic Geography of the Global Pesticide Industry

Journal of Agrarian Change, EarlyView.
ABSTRACT The global pesticide industry transformed from one dominated by patented products and legacy multinationals with strong manufacturing bases in the United States and EU to one dominated by generic products produced in India and China. We use proprietary market research data, data from regulatory filings, industry press and bilateral trade data ...
Christian Berndt, Marion Werner, Finn Mempel, Annie Shattuck, Zackary Okun Dunivin   +4 more
wiley   +1 more source

The Sulfonylurea Drug, Glimepiride, Stimulates Glucose Transport, Glucose Transporter Translocation, and Dephosphorylation In Insulin-Resistant Rat Adipocytes In Vitro [PDF]

, 1993
Wied, Susanne, Müller, Günter
core   +1 more source

Signaling and sites of interaction for RX-871024 and sulfonylurea in the stimulation of insulin release

, 1998
The objective of this study was to compare effects of RX-871024, a compound with imidazoline structure, and the sulfonylurea glibenclamide, representatives of two groups of ATP-dependent potassium channel (KATP) blockers, on insulin secretion and ...
Berggren, PO, Claes-Göran Östenson, Zaitsev, SV, Zaitsev, Sergei V., Efendic, S, Efanova, IB, Berggren, Per-Olof, Suad Efendić, Ioulia B. Efanova, Alexandre M. Efanov, Östenson, CG, Zhu, SS, Sergei V. Zaitsev, Efanova, Ioulia B., Zhu, Shunsheng, Efanov, Alexandre M., Efanov, AM, Shunsheng Zhu, Efendić, Suad, Östenson, Claes-Göran, Per-Olof Berggren   +20 more
core   +1 more source

The Capital–Labour–State Dynamics of Herbicide Adoption in Rainfed India

Journal of Agrarian Change, EarlyView.
ABSTRACT This paper engages debates around the capital–labour–state dynamics of agrarian transitions to address the oft‐studied but still little‐understood question of why farmers adopt herbicides when they do. Over the last several years, smallholder farmers in India have begun using the herbicide bispyribac sodium at breakneck speeds, particularly in
Carly Nichols, Nidhi Kumari
wiley   +1 more source

Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study

, 2020
Background: Due to several limitations in the study designs of sulfonylurea pharmacogenomics studies, we investigated the clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients.
Vethakkan, Shireene Ratna, Hussein, Zanariah, Huri, Hasniza Zaman, Loganadan, Navin Kumar   +3 more
core  

Sulfonylurea Receptor-1: A Novel Biomarker for Cerebral Edema in Severe Traumatic Brain Injury

, 2017
OBJECTIVES: Cerebral edema is a key poor prognosticator in traumatic brain injury. There are no biomarkers identifying patients at-risk, or guiding mechanistically-precise therapies.
Chang, Chung-Chou H, Wallisch, Jessica S, Ruchira M. Jha, Ava M. Puccio, Patrick M. Kochanek, Keri L. Janesko-Feldman, Bradley J. Molyneaux, Sherry Hsiang-Yi Chou, Chung-Chou H. Chang, David O. Okonkwo, Jha, Ruchira M, Jessica S. Wallisch, Shutter, Lori A, Lori A. Shutter, Janesko-Feldman, Keri L, Chou, Sherry Hsiang-Yi, Molyneaux, Bradley J, Okonkwo, David O, Samuel M. Poloyac, Zusman, Benjamin E, Benjamin E. Zusman, Puccio, Ava M, Kochanek, Patrick M, Poloyac, Samuel M   +23 more
core   +1 more source

Habitual fasting duration and accelerated multimorbidity in older adults

Journal of Internal Medicine, EarlyView.
Abstract Background Prolonged fasting has been linked to metabolic benefits in younger adults, but its effects on chronic diseases in older populations remain unclear. Objective To examine the association between habitual fasting duration and 15‐year chronic disease accumulation in older adults, overall, within organ systems, and between age groups ...
Luis Kalmbach, David Abbad‐Gomez, Giorgi Beridze, Fernando Rodríguez‐Artalejo, Davide Liborio Vetrano, Amaia Calderón‐Larrañaga, Adrián Carballo‐Casla   +6 more
wiley   +1 more source