Results 131 to 140 of about 29,600 (252)

Novel Broccoli Sulforaphane-Based Analogues Inhibit the Progression of Pancreatic Cancer without Side Effects

Biomolecules, 2020
The naturally occurring isothiocyanate sulforaphane, found in Brassicaceae vegetables, is promising in cancer treatment, e.g., by the normalization of enhanced levels of NF-κB-signaling in tumor stem cells.
Christina Georgikou, Laura Buglioni, Maximilian Bremerich, Nico Roubicek, Libo Yin, Wolfgang Gross, Carsten Sticht, Carsten Bolm, Ingrid Herr   +8 more
doaj   +1 more source

Can sulforaphane prevent the onset or slow the progression of osteoarthritis? [PDF]

, 2016
Osteoarthritis (OA) is a degenerative joint disease characterised in part by destruction of articular cartilage. There are currently no disease-modifying drugs to treat OA, with joint replacement the only treatment offered to patients at end-stage ...
Burrage, Cawston, Chen, Conaway, Dashwood, Davidson, Dinkova-Kostova, Fosang, Gasper, Goldring, Goldring, Green, Healy, Heiss, Jakubikova, Juge, Kim, Kong, McHughes, Richmond, Shane Anderson   +20 more
core   +1 more source

The PI3K/AKT/mTOR Pathway and Oral Diseases: A Bibliometric Analysis From 2008 to 2025

Clinical and Experimental Dental Research, Volume 11, Issue 5, October 2025.
ABSTRACT Objectives The phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is a key therapeutic target for oral diseases. This study uses bibliometric analysis to identify research trends, knowledge gaps, and the development of PI3K/AKT/mTOR‐targeted therapies.
Yena Gan, Duoduo Li, He Xu, Sheng Han, He Zhu, Zening Wei, Zhigang Cai, Jinwei Huang   +7 more
wiley   +1 more source

Anticancer activity of sulforaphane against human hepatoblastoma cells involves apoptosis, autophagy and inhibition of β-catenin signaling pathway

Archives of Medical Science, 2020
Introduction Sulforaphane is an active isothiocyanate and has been reported to exhibit many pharmacological and biological activities including anticancer activity.
Junshan Lin, Yali Xu, Xing Zhao, Zhixin Qiu   +3 more
doaj   +1 more source

Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia. [PDF]

, 2014
Inherited deficiency in the mitochondrial protein frataxin (FXN) causes the rare disease Friedreich's ataxia (FA), for which there is no successful treatment. We identified a redox deficiency in FA cells and used this to model the disease.
Al-Mahdawi, Al-Mahdawi, Al-Mahdawi, Albano, Bidichandani, Brandon Brown, Brian D. Scott, Bridwell-Rabb, Campuzano, Catterall, Chantrel-Groussard, Chorley, Chutake, Condò, Cossée, Cox, De Biase, Deutsch, Drechsel, Dürr, Fahey, Filla, Florestano, Frank, Friedman, Gino A. Cortopassi, Greene, Hashemy, Heike Wulff, Huang, Kalinin, Kensler, Kim, Kim, Koeppen, Koeppen, Kosower, Kosower, Kruger, Lai, Larkin, Liu, Lopert, Lu, Lu, Marissa Z. McMackin, Mark A. Pook, Miranda, Mittal Jasoliya, Montermini, Osburn, Paredes-Gonzalez, Paupe, Riah, Sandi, Sangster, Saveliev, Schmitz-Hübsch, Selak, Shan, Shan, Shan, Shelmire, Sinha, Streck, Subramaniam, Sunil Sahdeo, Susan L. Perlman, Tan, Tan, Tella, Verdon, Wang, Wang, Weaver, Willis, Yang, Yu, Zhang   +78 more
core   +1 more source

Chemopreventive Activities of Sulforaphane and Its Metabolites in Human Hepatoma HepG2 Cells [PDF]

, 2018
Sulforaphane (SFN) exhibits chemopreventive effects through various mechanisms. However, few studies have focused on the bioactivities of its metabolites.
Bao, Yongping, Bowater, Richard P, Chen, Yuqiong, Liu, Peng, Smith, Andrew, Wang, Wei, Wormstone, Ian Michael, Zhou, Zhigang   +7 more
core   +3 more sources

Contents of sulforaphane and total isothiocyanates, antimutagenic activity, and inhibition of clastogenicity in pulp

Czech Journal of Food Sciences, 2011
The consumption of Cruciferous vegetables is important for the prevention of cancerous diseases, particularly colorectal cancer. The effects of technological treatments (freezing, pasteurisation, high-pressure treatment) on the content of isothiocyanates,
Jiří Totušek, Jan Tříska, Danuše Lefnerová, Jan Strohalm, Naděžda Vrchotová, Ondřej Zendulka, Jiřina Průchová, Jana Chaloupková, Pavla Novotná, Milan Houška   +9 more
doaj   +1 more source

Sulforaphane Prevents Colitis-associated Cancer by Inducing Phase II Enzymes Activity of Liver Detoxification [PDF]

, 2011
Ulcerative colitis (UC) is a kind of Inflammatory Bowel Disease (IBD) characterized by chronic inflammation that causes ulceration of the colonic mucosa and extends proximally from the rectum into the colon.
Darsono, L. (Lusiana), Khiong, K. (Khie), Yolanda, R. (Raissa)   +2 more
core  

Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

Acta Pharmaceutica Sinica B, 2021
Xiang Wang, Xinxin Chen, Wenqian Zhou, Hongbo Men, Terigen Bao, Yike Sun, Quanwei Wang, Yi Tan, B. Keller, Qian Tong, Yang Zheng, L. Cai   +11 more
semanticscholar   +1 more source

Sulforaphane Delays Intervertebral Disc Degeneration by Alleviating Endoplasmic Reticulum Stress in Nucleus Pulposus Cells via Activating Nrf-2/HO-1 [PDF]

, 2023
Xiao Lu, Guangyu Xu, Zhidi Lin, Jian Song, Yuxuan Zhang, Hongli Wang, Feizhou Lu, Xinlei Xia, Xiaosheng Ma, Fei Zou, Jianyuan Jiang   +10 more
openalex   +1 more source