Results 111 to 120 of about 22,428 (226)

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

The potential for dietary factors to prevent or treat osteoarthritis [PDF]

, 2014
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this ...
Bao, Yongping, Cassidy, Aedín, Clark, Ian M., Davidson, Rose K., Donell, Simon T., Green, Jonathan A., Hirst-Jones, Kimberley L., Jupp, Orla, Macgregor, Alexander J.   +8 more
core   +1 more source

The Dual Role of Methyl Caffeate: Growth Inhibition of Pseudomonas syringae and Induction of Resistance to Bacterial Speck Disease in Tomato

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
Methyl caffeate exhibits dual functionality against Pseudomonas syringae pv. tomato. It directly disrupts bacterial membrane integrity, induces reactive oxygen species accumulation, and inhibits flagellar motility and the type III secretion system. Concurrently, it primes plant defence by activating defence‐related gene expression and enzyme activities,
Yarui Yang, Jikai Yu, Jinxi Yang, Yulin Wang, Wenrui Hou, Dongfang Zhang, Jianquan Wang, Wenfeng Nie, Yan Zhang, Xiaoyun Wang, Xiuming Li, Qinghua Shi   +11 more
wiley   +1 more source

Friend and foe: factors influencing the movement of the bacterium Helicobacter pylori along the parasitism-mutualism continuum. [PDF]

, 2014
Understanding the transition of bacterial species from commensal to pathogen, or vice versa, is a key application of evolutionary theory to preventative medicine.
Koskella, Britt, Lin, Derek
core   +1 more source

Investigating Sulforaphane’s anti-virulence and anti-quorum sensing properties against Pseudomonas aeruginosa

Frontiers in Pharmacology
BackgroundP. aeruginosa, a significant bacterium, can cause severe illness and resistance to antibiotics. Quorum sensing (QS) systems regulate virulence factors production.
Mahmoud M. Bendary, Mohamed A. M. Ali, Mohamed A. M. Ali, Alyaa S. Abdel Halim, Fehmi Boufahja, Anis Ahmad Chaudhary, Amr Elkelish, Amr Elkelish, Rania H. M. Soliman, Wael A. H. Hegazy, Wael A. H. Hegazy   +10 more
doaj   +1 more source

Supplementation of the diet by exogenous myrosinase via mustard seeds to increase the bioavailability of sulforaphane in healthy human subjects after the consumption of cooked broccoli [PDF]

, 2018
Broccoli contains the glucosinolate glucoraphanin which, in the presence of myrosinase, can hydrolyse to the isothiocyanate sulforaphane, reported to have anti-carcinogenic activity. However, the myrosinase enzyme is denatured on cooking.
Armah, Bones, Clarke, Conaway, Cramer, Dekker, Dosz, Eylen, Eylen, Eylen, Ghawi, Kassahun, Keck, Lampe, Ludikhuyze, Matusheski, Matusheski, Murashima, Myzak, Oerlemans, Okunade, Perez, Radhika, Rouzaud, Rouzaud, Rungapamestry, Shapiro, Song, Verkerk, Vermeulen, Williams, Wu, Yen, Zhang   +33 more
core   +1 more source

Contents of sulforaphane and total isothiocyanates, antimutagenic activity, and inhibition of clastogenicity in pulp

Czech Journal of Food Sciences, 2011
The consumption of Cruciferous vegetables is important for the prevention of cancerous diseases, particularly colorectal cancer. The effects of technological treatments (freezing, pasteurisation, high-pressure treatment) on the content of isothiocyanates,
Jiří Totušek, Jan Tříska, Danuše Lefnerová, Jan Strohalm, Naděžda Vrchotová, Ondřej Zendulka, Jiřina Průchová, Jana Chaloupková, Pavla Novotná, Milan Houška   +9 more
doaj   +1 more source

Identifying chondroprotective diet-derived bioactives and investigating their synergism [PDF]

, 2018
Osteoarthritis (OA) is a multifactorial disease and nutrition is a modifiable factor that may contribute to disease onset or progression. A detailed understanding of mechanisms through which diet-derived bioactive molecules function and interact in OA is
A Facchini, A Mobasheri, A Moncada-Pazos, A Yokomizo, AA Kiadaliri, AD Woolf, AD Woolf, AT Dinkova-Kostova, AT Dinkova-Kostova, B Javaheri, B Ji, B Ji, BJ Kang, BM Kaminski, C Sun, C Wang, C Zhuang, CD Kay, CJ Billington, E Heiss, F Berenbaum, FM Williams, G Valdameri, H Chen, H Lim, J Bondeson, J Cao, J Wang, J Yan, J Zeng, JA Green, JS Park, JY Ko, K Barnett, KH Miean, L Crasci, L Zhang, M Durigova, M Lopez-Lazaro, Marita Cross, MF Allam, MT Veeman, O Korchynskyi, Organization, G. W. H., Q Liu, R Balez, RK Davidson, RK Nuttall, S Mirzoeva, S Porter, SL Brennan-Olsen, T-C Chou, TC Chou, TF Heathfield, UR Kuppusamy, WD Shingleton, Y Li, Y Zhang, Y Zhang, Y Zhang, YJ Choi   +60 more
core   +2 more sources

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells [PDF]

, 2017
Silybum marianum (milk thistle) is a medicinal plant used for the treatment of various liver disorders. This study examined whether the main flavonolignans from S. marianum (i.e.
Abenavoli, Albena T. Dinkova-Kostova, Baird, Begum, Biedermann, Biedermann, Bonifaz, Borsari, Chambers, Chow, David Biedermann, Dinkova-Kostova, Dvorak, Dzubak, Fahey, Federico, Feher, Gazak, Gazak, Hayes, Jitka Ulrichová, Jiří Vrba, Krenek, Lenka Roubalová, Liang, Nioi, Prochazkova, Pyszkova, Roubalova, Surai, Tanigawa, Thongphasuk, Trouillas, Varga, Vladimír Křen, Vrba, Wang, Zhan, Zhang, Zhao   +39 more
core   +2 more sources

Oxidative stress in Duchenne muscular dystrophy: focus on the NRF2 redox pathway [PDF]

, 2017
Oxidative stress is involved in the pathogenesis of Duchenne muscular dystrophy (DMD), an X-linked genetic disorder caused by mutations in the dystrophin gene and characterized by progressive, lethal muscle degeneration and chronic inflammation.
Bertini, Enrico, Catteruccia, Michela, D'Amico, Adele, FORCINA, LAURA, MUSARO', Antonio, PELOSI, LAURA, Petrillo, Sara, Petrini, Stefania, Piemonte, Fiorella, Travaglini, Lorena, Verardo, Margherita   +10 more
core   +1 more source