Glucoraphanin conversion into sulforaphane and related compounds by gut microbiota [PDF]
Frontiers in PhysiologyGlucosinolate glucoraphanin, common in cruciferous vegetables, is a biologically stable precursor of isothiocyanates, such as sulforaphane and erucin, potent activators of Nrf2 signaling coordinating an adaptive response to oxidative stress. Sulforaphane
Tetiana R. Dmytriv +5 more
exaly +8 more sources
Optimization of Engineered Production of the Glucoraphanin Precursor Dihomomethionine in Nicotiana benthamiana [PDF]
Frontiers in Bioengineering and Biotechnology, 2016 Glucosinolates are natural products characteristic of the Brassicales order which include vegetables such as cabbages and the model plant Arabidopsis thaliana.
Christoph Crocoll +2 more
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Factors Influencing Glucoraphanin and Sulforaphane Formation in Brassica Plants: A Review
Journal of Integrative Agriculture, 2012 Sulforaphane is a type of sulfur-containing isothiocyanates hydrolyzed from glucosinolates by myrosinase found in Brassica plants. Sulforaphane is a naturally occurring inducer of phase II enzymes in human and animal bodies to detoxify cancer-causing ...
Zhen-xin GU, Qiang-hui GUO, Ying-juan GU
exaly +5 more sources
Anti-inflammatory activity of synthetic and natural glucoraphanin [PDF]
Journal of the Serbian Chemical Society, 2019 Glucoraphanin is one of the best known glucosinolates because of its health benefits. The compound is known to eliminate carcinogens in tissue and hence is frequently studied for its cancer preventative properties. In this work, the total synthesis of α-
Vo Quan V. +4 more
doaj +4 more sources
Glucoraphanin Accumulation via Glucoraphanin Synthesis Promotion during Broccoli Germination [PDF]
Foods, 2023 Glucoraphanin is an important glucosinolate which is widely distributed in Brassica vegetables and poses an anticancer effect to humans. Although researchers have paid a lot of attention to the changes in glucoraphanin concentration in seedlings of ...
Guangmin Liu +4 more
doaj +4 more sources
Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study [PDF]
Frontiers in NutritionBackgroundNuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates cellular defense mechanisms and has been proposed as a therapeutic target for Alzheimer’s disease (AD).
Sunao Shimizu +13 more
doaj +4 more sources
Effects of broccoli sprout supplements enriched in glucoraphanin on liver functions in healthy middle-aged adults with high-normal serum hepatic biomarkers: A randomized controlled trial [PDF]
Frontiers in Nutrition, 2022 Sulforaphane (SFN), an isothiocyanate derived from glucoraphanin, has antioxidant, and anti-inflammatory effects that may be beneficial for improving liver function.
Shohei Satomi +6 more
doaj +2 more sources
Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention—results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial [PDF]
, 2019 Background Epidemiological evidence suggests that consumption of cruciferous vegetables is associated with reduced risk of prostate cancer progression, largely attributed to the biological activity of glucosinolate degradation products, such as ...
Al Kadhi, Omar +18 more
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Broccoli or Sulforaphane: Is It the Source or Dose That Matters? [PDF]
Molecules, 2019 There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the isothiocyanate sulforaphane.
Yoko Yagishita +3 more
doaj +4 more sources
Sulforaphane in cancer precision medicine: from biosynthetic origins to multiscale mechanisms and clinical translation [PDF]
Frontiers in ImmunologySulforaphane (SFN), an isothiocyanate derived from glucoraphanin in cruciferous vegetables, has evolved from a dietary antioxidant to a sophisticated multi-target agent in oncology.
Zhipeng Zhao +11 more
doaj +2 more sources