Glucoraphanin conversion into sulforaphane and related compounds by gut microbiota [PDF]
Frontiers in PhysiologyGlucosinolate glucoraphanin, common in cruciferous vegetables, is a biologically stable precursor of isothiocyanates, such as sulforaphane and erucin, potent activators of Nrf2 signaling coordinating an adaptive response to oxidative stress. Sulforaphane
Tetiana R Dmytriv +2 more
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Glucoraphanin Accumulation via Glucoraphanin Synthesis Promotion during Broccoli Germination
Foods, 2023 Glucoraphanin is an important glucosinolate which is widely distributed in Brassica vegetables and poses an anticancer effect to humans. Although researchers have paid a lot of attention to the changes in glucoraphanin concentration in seedlings of ...
Guangmin Liu +4 more
doaj +5 more sources
Optimization of Heterologous Glucoraphanin Production In Planta [PDF]
ACS Synthetic Biology, 2022 Glucoraphanin is a plant specialized metabolite found in cruciferous vegetables that has long been a target for production in a heterologous host because it can subsequently be hydrolyzed to form the chemopreventive compound sulforaphane before and ...
Collin R Barnum, Patrick M Shih
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Optimization of Engineered Production of the Glucoraphanin Precursor Dihomomethionine in Nicotiana benthamiana [PDF]
Frontiers in Bioengineering and Biotechnology, 2016 Glucosinolates are natural products characteristic of the Brassicales order which include vegetables such as cabbages and the model plant Arabidopsis thaliana.
Christoph Crocoll +2 more
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In Vitro Insights into the Dietary Role of Glucoraphanin and Its Metabolite Sulforaphane in Celiac Disease. [PDF]
NutrientsSulforaphane is considered the bioactive metabolite of glucoraphanin after dietary consumption of broccoli sprouts. Although both molecules pass through the gut lumen to the large intestine in stable form, their biological impact on the first intestinal ...
Sonzogni E +10 more
europepmc +7 more sources
Reduction of the sulfoxide in glucoraphanin and sulforaphane by E. coli VL11 and BL21 (DE3) [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2016 Sulfoxide reductase activity of two Escherichia coli strains VL11 from human feces and BL21(DE3) from a molecular cloning host was expressed upon glucoraphanin induction for 16 hrs at 37°C under aerobic conditions.
Vijitra Luang-In +1 more
doaj +3 more sources
Factors Influencing Glucoraphanin and Sulforaphane Formation in Brassica Plants: A Review
Journal of Integrative Agriculture, 2012 Sulforaphane is a type of sulfur-containing isothiocyanates hydrolyzed from glucosinolates by myrosinase found in Brassica plants. Sulforaphane is a naturally occurring inducer of phase II enzymes in human and animal bodies to detoxify cancer-causing ...
Zhen-xin GU, Qiang-hui GUO, Ying-juan GU
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Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase. [PDF]
PLoS ONE, 2015 Glucoraphanin from broccoli and its sprouts and seeds is a water soluble and relatively inert precursor of sulforaphane, the reactive isothiocyanate that potently inhibits neoplastic cellular processes and prevents a number of disease states ...
Jed W Fahey +5 more
doaj +5 more sources
Enriching Glucoraphanin in Brassica rapa Through Replacement of BrAOP2.2/BrAOP2.3 with Non-functional Genes [PDF]
Frontiers in Plant Science, 2017 Sulforaphane, the hydrolytic product of glucoraphanin glucosinolate, is a potent anticarcinogen that reduces the risk of several human cancers. However, in most B. rapa vegetables, glucoraphanin is undetectable or only present in trace amounts, since the
Jianli Liang +2 more
exaly +4 more sources
Effect of Glucoraphanin on the Abundance of Nrf2 Regulated Genes Within Circulating Small Extracellular Vesicles: A Pilot Dietary Intervention. [PDF]
Mol Nutr Food ResCruciferous vegetables, including broccoli, are associated with a reduced risk of age‐related chronic diseases. Broccoli accumulates glucoraphanin, which is hydrolyzed to sulforaphane, an isothiocyanate, that activates antioxidant genes via nuclear ...
Mitra N +10 more
europepmc +3 more sources