Results 1 to 10 of about 2,803 (180)

Glucoraphanin conversion into sulforaphane and related compounds by gut microbiota [PDF]

Frontiers in Physiology
Glucosinolate glucoraphanin, common in cruciferous vegetables, is a biologically stable precursor of isothiocyanates, such as sulforaphane and erucin, potent activators of Nrf2 signaling coordinating an adaptive response to oxidative stress. Sulforaphane
Volodymyr Lushchak, Oleh Lushchak
exaly   +8 more sources

Optimization of Engineered Production of the Glucoraphanin Precursor Dihomomethionine in Nicotiana benthamiana [PDF]

Frontiers in Bioengineering and Biotechnology, 2016
Glucosinolates are natural products characteristic of the Brassicales order which include vegetables such as cabbages and the model plant Arabidopsis thaliana.
Jonathan Gershenzon, Barbara Halkier, Michael Reichelt   +2 more
exaly   +11 more sources

Glucoraphanin Accumulation via Glucoraphanin Synthesis Promotion during Broccoli Germination

Foods, 2023
Glucoraphanin is an important glucosinolate which is widely distributed in Brassica vegetables and poses an anticancer effect to humans. Although researchers have paid a lot of attention to the changes in glucoraphanin concentration in seedlings of ...
Guangmin Liu, Hongju He, Pengjie Wang, Xirui Zhao, Fazheng Ren   +4 more
doaj   +4 more sources

Factors Influencing Glucoraphanin and Sulforaphane Formation in Brassica Plants: A Review

Journal of Integrative Agriculture, 2012
Sulforaphane is a type of sulfur-containing isothiocyanates hydrolyzed from glucosinolates by myrosinase found in Brassica plants. Sulforaphane is a naturally occurring inducer of phase II enzymes in human and animal bodies to detoxify cancer-causing ...
Zhen-xin GU, Qiang-hui GUO, Ying-juan GU
exaly   +5 more sources

Sulforaphane in cancer precision medicine: from biosynthetic origins to multiscale mechanisms and clinical translation [PDF]

Frontiers in Immunology
Sulforaphane (SFN), an isothiocyanate derived from glucoraphanin in cruciferous vegetables, has evolved from a dietary antioxidant to a sophisticated multi-target agent in oncology.
Zhipeng Zhao, Zhipeng Zhao, Zhipeng Zhao, Qianyue Chen, Xinyu Qiao, Xinyu Qiao, Xinyu Qiao, Jianjiang Wang, Zaid Tala Abdulqader Ali, Jun Li, Ling Yin, Ling Yin   +11 more
doaj   +2 more sources

Sulforaphane Determination by GC-MS Analysis: Mitigation of Thermal Degradation and Quality Evaluation of Two Broccoli-Based Supplements [PDF]

Molecules
Sulforaphane (SF), the renowned hydrolysis product of glucoraphanin from broccoli, is known to undergo thermal degradation to 3-butenyl isothiocyanate (3-BITC) during gas chromatography–mass spectrometry (GC-MS) analysis. In this study, the effects on SF
Valentina Melini, Irene Baiamonte, Francesca Masciola, Antonio Raffo, Gina Rosalinda De Nicola   +4 more
doaj   +2 more sources

Sulforaphane and Broccoli-Derived Preparations in Obesity and Obesity-Related Metabolic Dysfunction: Mechanistic Insights, Preclinical Evidence, and Clinical Perspectives [PDF]

Pharmaceuticals
Background/Objectives: Obesity is a major global health challenge characterized by adipose tissue dysfunction, insulin resistance, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, and increased cardiometabolic risk.
Efthymios Poulios, Sousana K. Papadopoulou, Evmorfia Psara, Dimitrios Tasoulas, Constantinos Giaginis   +4 more
doaj   +2 more sources

Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study [PDF]

Frontiers in Nutrition
BackgroundNuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates cellular defense mechanisms and has been proposed as a therapeutic target for Alzheimer’s disease (AD).
Sunao Shimizu, Sunao Shimizu, Shuya Kasai, Shuya Kasai, Chieko Suzuki, Tomoya Kon, Hiroyuki Suganuma, Shigenori Suzuki, Koichi Murashita, Shigeyuki Nakaji, Kazushige Ihara, Masahiko Tomiyama, Ken Itoh, Ken Itoh   +13 more
doaj   +2 more sources

Hydrogel Beads Loaded with Glucosinolate-Rich Brassicaceae Extract as a Controlled-Release Alternative to Biofumigation [PDF]

Molecules
Biofumigation was originally proposed as an alternative to toxic fumigants for the treatment of agricultural soils, owing to the biocidal effect of isothiocyanates (ITCs) released by some plant species like Brassicaceae.
Michele Baglioni, Ilaria Clemente, Raffaello Nardin, Flavia Bisozzi, Sara Costantini, Giacomo Fattori, Gabriella Tamasi, Claudio Rossi   +7 more
doaj   +2 more sources

Glucoraphanin Triggers Rapid Antidepressant Responses in a Rat Model of Beta Amyloid-Induced Depressive-like Behaviour

Pharmaceuticals, 2022
Glucoraphanin (GRA) is a natural compound that has shown beneficial effects in chronic diseases and in central nervous system disorders. Moreover, GRA displayed antidepressant activity in preclinical models.
Paolo Tucci, Lorenzo di Cesare Mannelli, Carla Ghelardini   +2 more
exaly   +3 more sources