Glucoraphanin conversion into sulforaphane and related compounds by gut microbiota [PDF]
Frontiers in PhysiologyGlucosinolate glucoraphanin, common in cruciferous vegetables, is a biologically stable precursor of isothiocyanates, such as sulforaphane and erucin, potent activators of Nrf2 signaling coordinating an adaptive response to oxidative stress. Sulforaphane
Volodymyr Lushchak, Oleh Lushchak
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Sulforaphane in cancer precision medicine: from biosynthetic origins to multiscale mechanisms and clinical translation [PDF]
Frontiers in ImmunologySulforaphane (SFN), an isothiocyanate derived from glucoraphanin in cruciferous vegetables, has evolved from a dietary antioxidant to a sophisticated multi-target agent in oncology.
Zhipeng Zhao +11 more
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Frontiers in Plant Science, 2017 Sulforaphane, the hydrolytic product of glucoraphanin glucosinolate, is a potent anticarcinogen that reduces the risk of several human cancers. However, in most B. rapa vegetables, glucoraphanin is undetectable or only present in trace amounts, since the
Wencai Yang, Xiaowu Wang, Feng Cheng
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Frontiers in Bioengineering and Biotechnology, 2016 Glucosinolates are natural products characteristic of the Brassicales order which include vegetables such as cabbages and the model plant Arabidopsis thaliana.
Jonathan Gershenzon +2 more
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Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study [PDF]
Frontiers in NutritionBackgroundNuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates cellular defense mechanisms and has been proposed as a therapeutic target for Alzheimer’s disease (AD).
Sunao Shimizu +13 more
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Hydrogel Beads Loaded with Glucosinolate-Rich Brassicaceae Extract as a Controlled-Release Alternative to Biofumigation [PDF]
MoleculesBiofumigation was originally proposed as an alternative to toxic fumigants for the treatment of agricultural soils, owing to the biocidal effect of isothiocyanates (ITCs) released by some plant species like Brassicaceae.
Michele Baglioni +7 more
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Glucosinolate–Myrosinase Formulations for Adult Obesity: Towards Next Generation of Bioactive Therapies [PDF]
FoodsThe rising global prevalence of obesity and metabolic disorders calls for innovative dietary strategies that can modulate key enzymatic pathways involved in lipid and carbohydrate metabolism.
Concepción Medrano-Padial +4 more
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Factors Influencing Glucoraphanin and Sulforaphane Formation in Brassica Plants: A Review
Journal of Integrative Agriculture, 2012 Sulforaphane is a type of sulfur-containing isothiocyanates hydrolyzed from glucosinolates by myrosinase found in Brassica plants. Sulforaphane is a naturally occurring inducer of phase II enzymes in human and animal bodies to detoxify cancer-causing ...
Zhen-xin GU, Qiang-hui GUO, Ying-juan GU
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Glucoraphanin Accumulation via Glucoraphanin Synthesis Promotion during Broccoli Germination
Foods, 2023 Glucoraphanin is an important glucosinolate which is widely distributed in Brassica vegetables and poses an anticancer effect to humans. Although researchers have paid a lot of attention to the changes in glucoraphanin concentration in seedlings of ...
Guangmin Liu +4 more
doaj +1 more source
Anti-inflammatory activity of synthetic and natural glucoraphanin [PDF]
Journal of the Serbian Chemical Society, 2019 Glucoraphanin is one of the best known glucosinolates because of its health benefits. The compound is known to eliminate carcinogens in tissue and hence is frequently studied for its cancer preventative properties. In this work, the total synthesis of α-
Vo Quan V. +4 more
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