Glucoraphanin conversion into sulforaphane and related compounds by gut microbiota [PDF]
Frontiers in PhysiologyGlucosinolate glucoraphanin, common in cruciferous vegetables, is a biologically stable precursor of isothiocyanates, such as sulforaphane and erucin, potent activators of Nrf2 signaling coordinating an adaptive response to oxidative stress. Sulforaphane
Volodymyr I. Lushchak, Oleh Lushchak
exaly +4 more sources
Glucoraphanin Accumulation via Glucoraphanin Synthesis Promotion during Broccoli Germination
Foods, 2023 Glucoraphanin is an important glucosinolate which is widely distributed in Brassica vegetables and poses an anticancer effect to humans. Although researchers have paid a lot of attention to the changes in glucoraphanin concentration in seedlings of ...
Guangmin Liu +4 more
doaj +2 more sources
Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase. [PDF]
PLoS ONE, 2015 Glucoraphanin from broccoli and its sprouts and seeds is a water soluble and relatively inert precursor of sulforaphane, the reactive isothiocyanate that potently inhibits neoplastic cellular processes and prevents a number of disease states ...
Jed W Fahey +5 more
doaj +2 more sources
Optimization of engineered production of the glucoraphanin precursor dihomo-methionine in Nicotiana benthamiana [PDF]
Frontiers in Bioengineering and Biotechnology, 2016 Glucosinolates are natural products characteristic of the Brassicales order which include vegetables such as cabbages and the model plant Arabidopsis thaliana.
Christoph eCrocoll +7 more
doaj +3 more sources
Reduction of the sulfoxide in glucoraphanin and sulforaphane by E. coli VL11 and BL21 (DE3) [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2016 Sulfoxide reductase activity of two Escherichia coli strains VL11 from human feces and BL21(DE3) from a molecular cloning host was expressed upon glucoraphanin induction for 16 hrs at 37°C under aerobic conditions.
Vijitra Luang-In +1 more
doaj +2 more sources
Enriching Glucoraphanin in Brassica rapa Through Replacement of BrAOP2.2/BrAOP2.3 with Non-functional Genes [PDF]
Frontiers in Plant Science, 2017 Sulforaphane, the hydrolytic product of glucoraphanin glucosinolate, is a potent anticarcinogen that reduces the risk of several human cancers. However, in most B. rapa vegetables, glucoraphanin is undetectable or only present in trace amounts, since the
Zhiyuan Liu +8 more
doaj +2 more sources
Molecules, 2015 Glucoraphanin is a plant secondary metabolite that is involved in plant defense and imparts health-promoting properties to cruciferous vegetables. In this study, three genes involved in glucoraphanin metabolism, branched-chain aminotransferase 4 (BCAT4),
Ling Yin +4 more
doaj +2 more sources
Sulforaphane Determination by GC-MS Analysis: Mitigation of Thermal Degradation and Quality Evaluation of Two Broccoli-Based Supplements [PDF]
MoleculesSulforaphane (SF), the renowned hydrolysis product of glucoraphanin from broccoli, is known to undergo thermal degradation to 3-butenyl isothiocyanate (3-BITC) during gas chromatography–mass spectrometry (GC-MS) analysis. In this study, the effects on SF
Valentina Melini +4 more
doaj +2 more sources
Sulforaphane in cancer precision medicine: from biosynthetic origins to multiscale mechanisms and clinical translation [PDF]
Frontiers in ImmunologySulforaphane (SFN), an isothiocyanate derived from glucoraphanin in cruciferous vegetables, has evolved from a dietary antioxidant to a sophisticated multi-target agent in oncology.
Zhipeng Zhao +11 more
doaj +2 more sources
Sulforaphane and Broccoli-Derived Preparations in Obesity and Obesity-Related Metabolic Dysfunction: Mechanistic Insights, Preclinical Evidence, and Clinical Perspectives [PDF]
PharmaceuticalsBackground/Objectives: Obesity is a major global health challenge characterized by adipose tissue dysfunction, insulin resistance, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, and increased cardiometabolic risk.
Efthymios Poulios +4 more
doaj +2 more sources