Results 11 to 20 of about 3,475 (207)

Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study [PDF]

Frontiers in Nutrition
BackgroundNuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates cellular defense mechanisms and has been proposed as a therapeutic target for Alzheimer’s disease (AD).
Sunao Shimizu, Sunao Shimizu, Shuya Kasai, Shuya Kasai, Chieko Suzuki, Tomoya Kon, Hiroyuki Suganuma, Shigenori Suzuki, Koichi Murashita, Shigeyuki Nakaji, Kazushige Ihara, Masahiko Tomiyama, Ken Itoh, Ken Itoh   +13 more
doaj   +3 more sources

Beneficial Effect of H2S-Releasing Molecules in an In Vitro Model of Sarcopenia: Relevance of Glucoraphanin

International Journal of Molecular Sciences, 2022
Sarcopenia is a gradual and generalized skeletal muscle (SKM) syndrome, characterized by the impairment of muscle components and functionality. Hydrogen sulfide (H2S), endogenously formed within the body from the activity of cystathionine-γ-lyase (CSE ...
L. Micheli, E. Mitidieri, Carlotta Turnaturi, D. Vanacore, C. Ciampi, E. Lucarini, G. Cirino, C. Ghelardini, R. Sorrentino, L. di Cesare Mannelli, R. d'Emmanuele di Villa Bianca   +10 more
semanticscholar   +6 more sources

Correction: Liu et al. Glucoraphanin Accumulation via Glucoraphanin Synthesis Promotion during Broccoli Germination. Foods 2024, 13, 41. [PDF]

Foods
In the original publication [...].
Liu G, He H, Wang P, Zhao X, Ren F.
europepmc   +4 more sources

Broccoli-Derived Glucoraphanin Activates AMPK/PGC1α/NRF2 Pathway and Ameliorates Dextran-Sulphate-Sodium-Induced Colitis in Mice

Antioxidants, 2022
As the prevalence of inflammatory bowel diseases (IBD) rises, the etiology of IBD draws increasing attention. Glucoraphanin (GRP), enriched in cruciferous vegetables, is a precursor of sulforaphane, known to have anti-inflammatory and antioxidative ...
Qiyu Tian, Zhixin Xu, Qi Sun, Alejandro Bravo Iniguez, Min Du, Mei-Jun Zhu   +5 more
doaj   +3 more sources

Genetic regulation of glucoraphanin accumulation in Beneforté^® broccoli [PDF]

New Phytologist, 2013
Summary Diets rich in broccoli (Brassica oleracea var italica) have been associated with maintenance of cardiovascular health and reduction in risk of cancer. These health benefits have been attributed to glucoraphanin that specifically accumulates in broccoli.
Traka, Maria H., Saha, Shikha, Huseby, Stine, Kopriva, Stanislav, Walley, Peter Glen, Barker, Guy C., Moore, Jonathan D., Mero, Gene, van den Bosch, Frans, Constant, Howard, Kelly, Leo, Schepers, Hans, Boddupalli, Sekhar, Mithen, Richard F.   +13 more
openaire   +4 more sources

Anti-inflammatory activity of synthetic and natural glucoraphanin [PDF]

Journal of the Serbian Chemical Society, 2019
Glucoraphanin is one of the best known glucosinolates because of its health benefits. The compound is known to eliminate carcinogens in tissue and hence is frequently studied for its cancer preventative properties. In this work, the total synthesis of α-
Vo Quan V., Nam Pham C., Dinh Thuc N., Mechler Adam, Tran Thi T.V.   +4 more
doaj   +3 more sources

High-level production of health-beneficial glucoraphanin by multiplex editing of AOP2 gene family in mustard. [PDF]

Plant Biotechnol J
Intake of glucosinolates through the consumption of cruciferous vegetables has been associated with numerous health benefits. In recent decades, glucosinolate glucoraphanin has gained a lot of attention, as its hydrolysis product (sulforaphane) is known ...
Kumar P, Bisht NC.
europepmc   +2 more sources

Sulforaphane in cancer precision medicine: from biosynthetic origins to multiscale mechanisms and clinical translation [PDF]

Frontiers in Immunology
Sulforaphane (SFN), an isothiocyanate derived from glucoraphanin in cruciferous vegetables, has evolved from a dietary antioxidant to a sophisticated multi-target agent in oncology.
Zhipeng Zhao, Zhipeng Zhao, Zhipeng Zhao, Qianyue Chen, Xinyu Qiao, Xinyu Qiao, Xinyu Qiao, Jianjiang Wang, Zaid Tala Abdulqader Ali, Jun Li, Ling Yin, Ling Yin   +11 more
doaj   +2 more sources

Short-Term Effects of Broccoli-Derived Glucoraphanin on Recovery from Eccentric Muscle Damage: A Double-Blind Randomized Crossover Study. [PDF]

Nutrients
Background/Objectives: Broccoli-derived glucoraphanin (a sulforaphane precursor that activates Nrf2 defenses) may aid repair; however, its short-term effects in humans remain unknown.
Cesanelli L, Thomas R, Mickevičius M, Sniečkus A, Mickevičienė D, Venckūnas T, Stasiulis A, Kamandulis S.   +7 more
europepmc   +2 more sources

Exogenous myrosinase from mustard seed increases bioavailability of sulforaphane from a glucoraphanin-rich broccoli seed extract in a randomized clinical study. [PDF]

Sci Rep
Inactive glucoraphanin (GR) in broccoli is converted to the antioxidant, anti-inflammatory, and anti-bacterial sulforaphane (SF) by cruciferous vegetable enzyme myrosinase (Myr), or similar enzymes from specific gut bacteria; both sources have variable ...
Mastaloudis A, Holcomb L, Fahey JW, Olson C, Nieman DC, Kay C, O'Donnell R, Pecorelli A, Kinney M, Li Y, Ishaq SL, Valacchi G.   +11 more
europepmc   +2 more sources