Glucosinolate–Myrosinase Formulations for Adult Obesity: Towards Next Generation of Bioactive Therapies [PDF]
FoodsThe rising global prevalence of obesity and metabolic disorders calls for innovative dietary strategies that can modulate key enzymatic pathways involved in lipid and carbohydrate metabolism.
Concepción Medrano-Padial +4 more
doaj +2 more sources
Glucoraphanin Triggers Rapid Antidepressant Responses in a Rat Model of Beta Amyloid-Induced Depressive-like Behaviour [PDF]
Pharmaceuticals, 2022 Glucoraphanin (GRA) is a natural compound that has shown beneficial effects in chronic diseases and in central nervous system disorders. Moreover, GRA displayed antidepressant activity in preclinical models.
Paolo Tucci +8 more
doaj +2 more sources
Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: evidence from randomised controlled trials [PDF]
Molecular Nutrition & Food Research, 2015 Cruciferous-rich diets have been associated with reduction in plasma LDL-cholesterol (LDL-C), which may be due to the action of isothiocyanates derived from glucosinolates that accumulate in these vegetables.
Armah, Charlotte N. +9 more
core +8 more sources
High-level production of health-beneficial glucoraphanin by multiplex editing of AOP2 gene family in mustard. [PDF]
Plant Biotechnol JKumar P, Bisht NC.
europepmc +3 more sources
Exogenous myrosinase from mustard seed increases bioavailability of sulforaphane from a glucoraphanin-rich broccoli seed extract in a randomized clinical study. [PDF]
Sci RepMastaloudis A +11 more
europepmc +3 more sources
Optimization of Heterologous Glucoraphanin Production In Planta [PDF]
ACS Synthetic Biology, 2022 Glucoraphanin is a plant specialized metabolite found in cruciferous vegetables that has long been a target for production in a heterologous host because it can subsequently be hydrolyzed to form the chemopreventive compound sulforaphane before and during consumption.
Collin R. Barnum +4 more
openaire +3 more sources
Effect of Glucoraphanin on the Abundance of Nrf2 Regulated Genes Within Circulating Small Extracellular Vesicles: A Pilot Dietary Intervention. [PDF]
Mol Nutr Food ResBroccoli accumulates glucoraphanin, converted to sulforaphane, which activates nuclear factor erythroid 2‐related factor 2 (Nrf2), which may reduce age‐related inflammation. Given sulforaphane's rapid excretion, we hypothesised that its effects are mediated via plasma extracellular vesicles (EVs).
Mitra N +10 more
europepmc +2 more sources
In Vitro Insights into the Dietary Role of Glucoraphanin and Its Metabolite Sulforaphane in Celiac Disease. [PDF]
NutrientsSonzogni E +10 more
europepmc +3 more sources
Toxicological assessment of truebroc® glucoraphanin-rich broccoli seed extract [PDF]
Toxicology Research and Application, 2022 TrueBroc® Glucoraphanin-Rich Broccoli Seed Extract (TrueBroc®), is a hot water extract of Brassica oleracea var. Italica Plenck (Brassicaceae) seeds. The broccoli seeds are non-genetically modified and are tested and selected for their specific glucosinolate content.
Claire Kruger +2 more
openalex +3 more sources