Results 21 to 30 of about 2,817 (157)

Novel Gram-Scale Production of Enantiopure R-Sulforaphane from Tuscan Black Kale Seeds

Molecules, 2014
Dietary R-sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. Furthermore, sulforaphane is currently being used in clinical trials to assess its effects against different tumour processes. This study reports an efficient preparation of
Gina Rosalinda De Nicola, Patrick Rollin, Emanuela Mazzon, Renato Iori   +3 more
doaj   +2 more sources

A Comparative Study of Brassica Sprout Extracts on Intestinal Inflammation and Epithelial Barrier Integrity [PDF]

Foods
The consumption of Brassica spp. vegetables has been associated with antioxidant, anti-inflammatory, and prebiotic effects, mainly attributed to glucosinolates and polyphenols which are abundant in sprouts.
Stefano Piazza, Carola Pozzoli, Marco Fumagalli, Nicole Maranta, Safwa Moheb El Haddad, Lorenzo Zanardo, Luigi Alberto Marrari, Chiara Di Lorenzo, Giulia Martinelli, Enrico Sangiovanni, Mario Dell’Agli   +10 more
doaj   +2 more sources

Factors Influencing Glucoraphanin and Sulforaphane Formation in Brassica Plants: A Review

Journal of Integrative Agriculture, 2012
Sulforaphane is a type of sulfur-containing isothiocyanates hydrolyzed from glucosinolates by myrosinase found in Brassica plants. Sulforaphane is a naturally occurring inducer of phase II enzymes in human and animal bodies to detoxify cancer-causing ...
Zhen-xin GU, Qiang-hui GUO, Ying-juan GU
doaj   +2 more sources

Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study [PDF]

Frontiers in Nutrition
BackgroundNuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates cellular defense mechanisms and has been proposed as a therapeutic target for Alzheimer’s disease (AD).
Sunao Shimizu, Sunao Shimizu, Shuya Kasai, Shuya Kasai, Chieko Suzuki, Tomoya Kon, Hiroyuki Suganuma, Shigenori Suzuki, Koichi Murashita, Shigeyuki Nakaji, Kazushige Ihara, Masahiko Tomiyama, Ken Itoh, Ken Itoh   +13 more
doaj   +2 more sources

Hydrogel Beads Loaded with Glucosinolate-Rich Brassicaceae Extract as a Controlled-Release Alternative to Biofumigation [PDF]

Molecules
Biofumigation was originally proposed as an alternative to toxic fumigants for the treatment of agricultural soils, owing to the biocidal effect of isothiocyanates (ITCs) released by some plant species like Brassicaceae.
Michele Baglioni, Ilaria Clemente, Raffaello Nardin, Flavia Bisozzi, Sara Costantini, Giacomo Fattori, Gabriella Tamasi, Claudio Rossi   +7 more
doaj   +2 more sources

Sulforaphane-Producing <i>Lacticaseibacillus paracasei</i>CCFM1221 Combining Broccoli Seed Extract Improved the Hepatoprotective Effect on Lipopolysaccharide-Treated Mice. [PDF]

Food Sci Nutr
L. paracasei CCFM1221 was capable of converting glucoraphanin into sulforaphane. In LPS‐induced mice, co‐administration of L. paracasei CCFM1221 with BSE (rich in glucoraphanin) alleviated liver injury. This combined intervention increased colonic sulforaphane levels and enriched gut bacteria involved in SCFAs and sulforaphane production. These changes
Tang X, Wei Y, Guo W, Zhang Q, Zhao J, Chen W, Mao B, Cui S.   +7 more
europepmc   +2 more sources

Field investigation of glucosinolates and morphological traits in mitigating Psylliodes chrysocephala larval infestation through crop varieties and companion planting. [PDF]

Pest Manag Sci
Genotype and cropping system influenced oilseed rape ecophysiological traits, including glucosinolate compounds (glucoraphanin, glucobrassicanapin, and butyl‐glucosinolates) and biomass, which were linked to Psylliodes chrysocephala larval infestation, with varietal effects stronger than faba bean companion planting.
Magnin L, Jullien A, Baux A, Barbu C, Glauser G, Hiltpold I.   +5 more
europepmc   +2 more sources

Mechanism of Action and Therapeutic Potential of Sulforaphane in Skeletal Muscle Diseases: Molecular Pathways and Precision Medicine. [PDF]

Food Sci Nutr
Sulforaphane modulates mTOR, Nrf2, NF‐κB, and AMPK/PGC‐1α pathways to protect skeletal muscle and enable precision‐medicine intervention in ICU‐acquired weakness, sarcopenia, and diabetic myopathy. ABSTRACT Sulforaphane (SFN), a bioactive isothiocyanate abundant in cruciferous vegetables, has attracted growing interest as a potential nutraceutical ...
Zhao M, Huang B, Chen J, Li J, Zhu Z, Zhu G, Hu J, Li F, Feng J.   +8 more
europepmc   +2 more sources

Effects of broccoli sprout supplements enriched in glucoraphanin on liver functions in healthy middle-aged adults with high-normal serum hepatic biomarkers: A randomized controlled trial

Frontiers in Nutrition, 2022
Sulforaphane (SFN), an isothiocyanate derived from glucoraphanin, has antioxidant, and anti-inflammatory effects that may be beneficial for improving liver function.
Shohei Satomi, Shingo Takahashi, Kazutaka Yoshida, Sunao Shimizu, Takuro Inoue, Tsuyoshi Takara, Hiroyuki Suganuma   +6 more
doaj   +1 more source

Anti-inflammatory activity of synthetic and natural glucoraphanin [PDF]

Journal of the Serbian Chemical Society, 2019
Glucoraphanin is one of the best known glucosinolates because of its health benefits. The compound is known to eliminate carcinogens in tissue and hence is frequently studied for its cancer preventative properties. In this work, the total synthesis of α-
Vo Quan V., Nam Pham C., Dinh Thuc N., Mechler Adam, Tran Thi T.V.   +4 more
doaj   +1 more source