Results 21 to 30 of about 2,803 (180)

Beneficial Effect of H2S-Releasing Molecules in an In Vitro Model of Sarcopenia: Relevance of Glucoraphanin

International Journal of Molecular Sciences, 2022
Sarcopenia is a gradual and generalized skeletal muscle (SKM) syndrome, characterized by the impairment of muscle components and functionality. Hydrogen sulfide (H2S), endogenously formed within the body from the activity of cystathionine-γ-lyase (CSE), cystathionine- β-synthase (CBS), and mercaptopyruvate sulfurtransferase, is involved in SKM function.
Laura Micheli, Emma Mitidieri, Carlotta Turnaturi, Domenico Vanacore, Clara Ciampi, Elena Lucarini, Giuseppe Cirino, Carla Ghelardini, Raffaella Sorrentino, Lorenzo Di Cesare Mannelli, Roberta d’Emmanuele di Villa Bianca   +10 more
openaire   +5 more sources

Engineering of methionine chain elongation part of glucoraphanin pathway in E. coli

Metabolic Engineering, 2016
The methionine-derived glucosinolate glucoraphanin is associated with the health-promoting properties of broccoli. This has developed a strong interest in producing this compound in high amounts from a microbial source. Glucoraphanin synthesis starts with a five-gene chain elongation pathway that converts methionine to dihomo-methionine, which is ...
Mirza, Nadia Muhammad Akram, Crocoll, Christoph, Olsen, Carl Erik, Halkier, Barbara Ann   +3 more
openaire   +4 more sources

Quantitative determination of glucoraphanin in Brassica vegetables by micellar electrokinetic capillary chromatography

Analytica Chimica Acta, 2010
Glucoraphanin, a glucosinolate, is found naturally in plants and is present in relatively high concentrations in broccoli. Glucosinolates have received much attention as studies have indicated that a diet rich in them may provide some protection from certain cancers.
Iris, Lee, Mary C, Boyce, Michael C, Breadmore   +2 more
openaire   +3 more sources

In Vitro Insights into the Dietary Role of Glucoraphanin and Its Metabolite Sulforaphane in Celiac Disease [PDF]

Nutrients
Sulforaphane is considered the bioactive metabolite of glucoraphanin after dietary consumption of broccoli sprouts. Although both molecules pass through the gut lumen to the large intestine in stable form, their biological impact on the first intestinal tract is poorly described.
Sonzogni, Elisa, Martinelli, Giulia, Fumagalli, Marco, Maranta, Nicole, Pozzoli, Carola, Bani, Corinne, Marrari, Luigi Alberto, Di Lorenzo, Chiara, Sangiovanni, Enrico, Dell'Agli, Mario, Piazza, Stefano   +10 more
openaire   +4 more sources

Sulforaphane-Producing <i>Lacticaseibacillus paracasei</i>CCFM1221 Combining Broccoli Seed Extract Improved the Hepatoprotective Effect on Lipopolysaccharide-Treated Mice. [PDF]

Food Sci Nutr
L. paracasei CCFM1221 was capable of converting glucoraphanin into sulforaphane. In LPS‐induced mice, co‐administration of L. paracasei CCFM1221 with BSE (rich in glucoraphanin) alleviated liver injury. This combined intervention increased colonic sulforaphane levels and enriched gut bacteria involved in SCFAs and sulforaphane production. These changes
Tang X, Wei Y, Guo W, Zhang Q, Zhao J, Chen W, Mao B, Cui S.   +7 more
europepmc   +2 more sources

Mechanism of Action and Therapeutic Potential of Sulforaphane in Skeletal Muscle Diseases: Molecular Pathways and Precision Medicine. [PDF]

Food Sci Nutr
Sulforaphane modulates mTOR, Nrf2, NF‐κB, and AMPK/PGC‐1α pathways to protect skeletal muscle and enable precision‐medicine intervention in ICU‐acquired weakness, sarcopenia, and diabetic myopathy. ABSTRACT Sulforaphane (SFN), a bioactive isothiocyanate abundant in cruciferous vegetables, has attracted growing interest as a potential nutraceutical ...
Zhao M, Huang B, Chen J, Li J, Zhu Z, Zhu G, Hu J, Li F, Feng J.   +8 more
europepmc   +2 more sources

Effects of broccoli sprout supplements enriched in glucoraphanin on liver functions in healthy middle-aged adults with high-normal serum hepatic biomarkers: A randomized controlled trial

Frontiers in Nutrition, 2022
Sulforaphane (SFN), an isothiocyanate derived from glucoraphanin, has antioxidant, and anti-inflammatory effects that may be beneficial for improving liver function.
Shohei Satomi, Shingo Takahashi, Kazutaka Yoshida, Sunao Shimizu, Takuro Inoue, Tsuyoshi Takara, Hiroyuki Suganuma   +6 more
doaj   +1 more source

Effects of nanocarbon solution treatment on the nutrients and glucosinolate metabolism in broccoli

Food Chemistry: X, 2022
The effects of a nanocarbon solution on the nutrients, glucosinolate metabolism and glucoraphanin pathway in broccoli were investigated. Significant positive linear relationships were observed between the nanocarbon solution and total protein yield ...
Zhansheng Li, Guangmin Liu, Hongju He, Yumei Liu, Fengqing Han, Wei Liu   +5 more
doaj   +1 more source

Production of the Cancer-Preventive Glucoraphanin in Tobacco [PDF]

Molecular Plant, 2010
Epidemiological studies have demonstrated reduced risk of developing cancer upon consumption of diets rich in cruciferous vegetables. This chemoprevention has been largely attributed to the presence of the natural products glucosinolates, particularly the methionine-derived glucoraphanin from broccoli.
Mikkelsen, Michael Dalgaard, Olsen, Carl Erik, Halkier, Barbara Ann   +2 more
openaire   +3 more sources

Influence of sequential exogenous pretreatment and contact ultrasound-assisted air drying on the metabolic pathway of glucoraphanin in broccoli florets

Ultrasonics Sonochemistry, 2022
In this investigation, the combinations of exogenous pretreatment (melatonin or vitamin C) and contact ultrasound-assisted air drying were utilized to dry broccoli florets. To understand the influences of the studied dehydration methods on the conversion
Beini Liu, Yang Tao, Sivakumar Manickam, Dandan Li, Yongbin Han, Ying Yu, Dongfeng Liu   +6 more
doaj   +1 more source