Results 91 to 100 of about 16,517 (209)

Discovery of ERα‐Targeting Phytochemicals With In Vitro Cytotoxicity and Computational Prediction of Y537S Mutant Inhibition

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
Integrating high‐throughput virtual screening, cytotoxicity assays, and molecular dynamics simulations, this study identifies the phytochemical ibs‐04156 as a reliable dual‐action candidate across both wild‐type and mutated estrogen receptor alpha (ERα), while ibs‐18821 emerges as a potent allosteric inhibitor specifically targeting the drug‐resistant ...
Dejun Jiang, Oh Wook Kwon, Hanbin Joe, Euijeong Shin, Sungjoon Cho, Hyuk‐Ku Kwon, Youngjin Choi   +6 more
wiley   +1 more source

Transcriptome reveals the gene expression patterns of sulforaphane metabolism in broccoli florets.

PLoS ONE, 2019
Sulforaphane is a new and effective anti-cancer component that is abundant in broccoli. In the past few years, the patterns of variability in glucosinolate content and its regulation in A. thaliana have been described in detail. However, the diversity of
Zhansheng Li, Yumei Liu, Lingyun Li, Zhiyuan Fang, Limei Yang, Mu Zhuang, Yangyong Zhang, Honghao Lv   +7 more
doaj   +1 more source

17β-Estradiol enhances sulforaphane cardioprotection against oxidative stress [PDF]

, 2017
The lower incidence of ischemic heart disease in female with respect to male gender suggests the possibility that female sex hormones could have specific effects in cardiovascular protection.
ANGELONI, Cristina, Falconi, M, HRELIA, SILVANA, Malaguti, M, Hrelia, S., MALAGUTI, MARCO, Teti, G, Barbalace, Mc, BARBALACE, MARIA CRISTINA, FALCONI, MIRELLA, Angeloni, C, TETI, GABRIELLA   +11 more
core   +1 more source

Sulforaphane: a natural organosulfur having potential to modulate apoptosis and survival signalling in cancer

Discover Oncology
Owing to its ever-growing range of pharmacological advantages, sulforaphane, an isothiocyanate from cruciferous vegetables such as broccoli, is becoming increasingly popular.
Hemant Joshi, Isha Rani, Vikas Sharma, Ujjawal Sharma, Tanisha Dimri, Manoj Kumar, Ritu Chauhan, Abhishek Chauhan, Damandeep Kaur, Shafiul Haque, Faraz Ahmad, Hardeep Singh Tuli   +11 more
doaj   +1 more source

Repeated Nrf2 stimulation using sulforaphane protects fibroblasts from ionizing radiation

, 2014
Most of the cytotoxicity induced by ionizing radiation is mediated by radical-induced DNA double-strand breaks. Cellular protection from free radicals can be stimulated several fold by sulforaphane-mediated activation of the transcription factor Nrf2 ...
Mathew, Sherin T,, Bergström, Petra,, Hammarsten, Ola,   +2 more
core   +1 more source

Investigating Sulforaphane’s anti-virulence and anti-quorum sensing properties against Pseudomonas aeruginosa

Frontiers in Pharmacology
BackgroundP. aeruginosa, a significant bacterium, can cause severe illness and resistance to antibiotics. Quorum sensing (QS) systems regulate virulence factors production.
Mahmoud M. Bendary, Mohamed A. M. Ali, Mohamed A. M. Ali, Alyaa S. Abdel Halim, Fehmi Boufahja, Anis Ahmad Chaudhary, Amr Elkelish, Amr Elkelish, Rania H. M. Soliman, Wael A. H. Hegazy, Wael A. H. Hegazy   +10 more
doaj   +1 more source

Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment

, 2017
n the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate derived from glucoraphanin, occurring in large amounts in Brassica genus plants.
Daglia, Maria, Nabavi, Seyed Fazel, Russo, Maria, Russo, Gian Luigi, Spagnuolo, Carmela, Nabavi, Seyed Mohammad, Sobarzo-Sánchez, Eduardo, Skalicka-WoÅoniak, Krystyna   +7 more
core   +1 more source

Bioavailability of glucoraphanin and sulforaphane from high-glucoraphanin broccoli [PDF]

, 2018
Scope: Broccoli accumulates 4-methylsulphinylbutyl glucosinolate (glucoraphanin) which is hydrolyzed to the isothiocyanate sulforaphane. Through the introgression of novel alleles of the Myb28 transcription factor from Brassica villosa, broccoli ...
Maria H. Traka, Tapp, Henri S., Henri Tapp, Richard F. Mithen, Saha, Shikha, Paul W. Needs, Needs, Paul W., Traka, Maria H., Tharsini Sivapalan, Sivapalan, Tharsini, Shikha Saha, Antonietta Melchini, Dainty, Jack R., Mithen, Richard F., Jack R. Dainty, Melchini, Antonietta   +15 more
core   +1 more source

Contents of sulforaphane and total isothiocyanates, antimutagenic activity, and inhibition of clastogenicity in pulp

Czech Journal of Food Sciences, 2011
The consumption of Cruciferous vegetables is important for the prevention of cancerous diseases, particularly colorectal cancer. The effects of technological treatments (freezing, pasteurisation, high-pressure treatment) on the content of isothiocyanates,
Jiří Totušek, Jan Tříska, Danuše Lefnerová, Jan Strohalm, Naděžda Vrchotová, Ondřej Zendulka, Jiřina Průchová, Jana Chaloupková, Pavla Novotná, Milan Houška   +9 more
doaj   +1 more source

Sulforaphane as a Promising Molecule for Fighting Cancer

, 2013
Cancer is a complex disease characterized by multiple genetic and molecular alterations involving transformation, deregulation of apoptosis, proliferation, invasion, angiogenesis, and metastasis. To grow, invade, and metastasize, tumors need host components and primary dysfunction in the tumor microenvironment, in addition to cell dysfunction, can be ...
LENZI, MONIA, FIMOGNARI, CARMELA, HRELIA, PATRIZIA   +2 more
openaire   +2 more sources