Results 71 to 80 of about 16,517 (209)

Novel targets of sulforaphane in primary cardiomyocytes identified by proteomic analysis. [PDF]

PLoS ONE, 2013
Cardiovascular diseases represent the main cause of mortality in the industrialized world and the identification of effective preventive strategies is of fundamental importance.
Cristina Angeloni, Silvia Turroni, Laura Bianchi, Daniele Fabbri, Elisa Motori, Marco Malaguti, Emanuela Leoncini, Tullia Maraldi, Luca Bini, Patrizia Brigidi, Silvana Hrelia   +10 more
doaj   +1 more source

BoMyrosinase plays an essential role in sulforaphane accumulation in response to selenite treatment in broccoli

Horticultural Plant Journal
Sulforaphane, a naturally specialized metabolite, plays significant roles in human disease prevention and plant defense. Myrosinase (MY) is a key gene responsible for the catalysis of sulforaphane formation, but the molecular mechanisms through which MY ...
Qiuyun Wu, Qi Wu, Yuxiao Tian, Chunyan Zhou, Shuxiang Mao, Junwei Wang, Ke Huang   +6 more
doaj   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Interaction of Sulforaphane with DNA and RNA

PLOS ONE, 2015
Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables with anti-inflammatory, anti-oxidant and anti-cancer activities. However, the antioxidant and anticancer mechanism of sulforaphane is not well understood. In the present research, we reported binding modes, binding constants and stability of SFN-DNA and -RNA complexes by Fourier ...
Farzaneh Abassi Joozdani, Faramarz Yari, Parvaneh Abassi Joozdani, Shohreh Nafisi   +3 more
openaire   +4 more sources

Neuroprotective Effect of Sulforaphane against Methylglyoxal Cytotoxicity [PDF]

, 2015
Glycation, an endogenous process that leads to the production of advanced glycation end products (AGEs), plays a role in the etiopathogenesis of different neurodegenerative diseases, such as Alzheimer's disease (AD).
ANGELONI, Cristina, Malaguti, Marco, Barbalace, Maria Cristina, Hrelia, Silvana, Rizzo, Benedetta, Fabbri, Daniele   +5 more
core   +1 more source

Glutathione Biosynthesis via Activation of the Nuclear Factor E2–Related Factor 2 (Nrf2) – Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate

Journal of Pharmacological Sciences, 2011
Oxidative stress plays pivotal roles in aging, neurodegenerative disease, and pathological conditions such as ischemia. We investigated the effect of sulforaphane and 6-(methysulfinyl) hexyl isothiocyanate (6-HITC), a naturally occurring isothiocyanate ...
Keita Mizuno, Toshiaki Kume, Chie Muto, Yuki Takada-Takatori, Yasuhiko Izumi, Hachiro Sugimoto, Akinori Akaike   +6 more
doaj   +1 more source

Pharmacological Modulation of Nrf2 Signaling Regulates Oxidative Stress, Inflammation, and Alveolar Bone Loss in Experimental Periodontitis

Journal of Periodontal Research, EarlyView.
Pharmacological activation of Nrf2 attenuated alveolar bone loss and protected periodontal tissues by reducing inflammation and oxidative stress, preserving collagen organization, and favoring bone homeostasis. Reversal of these effects by Nrf2 inhibition further supports Nrf2 signaling as a promising therapeutic target in periodontitis.
Vitória Bonan Costa, Mariely Araújo de Godoi, Angelo Constantino Camilli, Isabela Rinaldi Gomes Nogueira, Veronica Canela Estevam dos Santos, Lucas Nogueira Ramos, Juliana Silva Siqueira, Camila Renata Corrêa Camacho, Morgana Rodrigues Guimarães Stabili   +8 more
wiley   +1 more source

Sulforaphane in experimental hypertension

Libyan International Medical University Journal, 2020
Abstract Background: Hypertension is defined as a failure to achieve a blood pressure (BP) target – smaller than 140/90 mmHg. The worldwide burden of hypertension has been associated with globally increased rates of death and disability. There is increasing evidence of strong relation between hypertension and oxidative stress, where either ...
Ali Banigesh, Vijitha Senanayake, Salma Bukhatwa, Bernhard Juurlink   +3 more
openaire   +2 more sources

Use of sulforaphane in COVID-19:Clinical trials are needed

, 2022
We read with interest the narrative review authored by Kiser et al. (2021), which discussed extensively the antioxidant effect and anti-inflammatory effect of sulforaphane, a dietary supplement found in high amounts in cruciferous vegetables that is ...
Ramachandram, Dinesh Sangarran, Kow, Chia Siang, Hasan, Syed Shahzad   +2 more
core   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source