Results 71 to 80 of about 12,016 (182)

Transcriptome reveals the gene expression patterns of sulforaphane metabolism in broccoli florets.

PLoS ONE, 2019
Sulforaphane is a new and effective anti-cancer component that is abundant in broccoli. In the past few years, the patterns of variability in glucosinolate content and its regulation in A. thaliana have been described in detail. However, the diversity of
Zhansheng Li, Yumei Liu, Lingyun Li, Zhiyuan Fang, Limei Yang, Mu Zhuang, Yangyong Zhang, Honghao Lv   +7 more
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, Volume 13, Issue 42, 28 July 2026.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Advances in the Core Role and Mechanisms of Mitochondrial Dysfunction in Alzheimer's Disease

Brain and Behavior, Volume 16, Issue 7, July 2026.
In Alzheimer's disease, Aβ and Tau trigger mitochondrial dysfunction, driving a pathological cascade that results in cognitive decline. Gut microbiota dysbiosis exacerbates this via the gut–brain axis, making mitochondria a key therapeutic target. ABSTRACT Introduction Alzheimer's disease (AD) is a complex neurodegenerative disorder whose pathogenesis ...
Tianyi Gu, Hangyan Guo, Zixin Guo, Shengyu Hua   +3 more
wiley   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Sulforaphane: a natural organosulfur having potential to modulate apoptosis and survival signalling in cancer

Discover Oncology
Owing to its ever-growing range of pharmacological advantages, sulforaphane, an isothiocyanate from cruciferous vegetables such as broccoli, is becoming increasingly popular.
Hemant Joshi, Isha Rani, Vikas Sharma, Ujjawal Sharma, Tanisha Dimri, Manoj Kumar, Ritu Chauhan, Abhishek Chauhan, Damandeep Kaur, Shafiul Haque, Faraz Ahmad, Hardeep Singh Tuli   +11 more
doaj   +1 more source

Investigating Sulforaphane’s anti-virulence and anti-quorum sensing properties against Pseudomonas aeruginosa

Frontiers in Pharmacology
BackgroundP. aeruginosa, a significant bacterium, can cause severe illness and resistance to antibiotics. Quorum sensing (QS) systems regulate virulence factors production.
Mahmoud M. Bendary, Mohamed A. M. Ali, Mohamed A. M. Ali, Alyaa S. Abdel Halim, Fehmi Boufahja, Anis Ahmad Chaudhary, Amr Elkelish, Amr Elkelish, Rania H. M. Soliman, Wael A. H. Hegazy, Wael A. H. Hegazy   +10 more
doaj   +1 more source

Contents of sulforaphane and total isothiocyanates, antimutagenic activity, and inhibition of clastogenicity in pulp

Czech Journal of Food Sciences, 2011
The consumption of Cruciferous vegetables is important for the prevention of cancerous diseases, particularly colorectal cancer. The effects of technological treatments (freezing, pasteurisation, high-pressure treatment) on the content of isothiocyanates,
Jiří Totušek, Jan Tříska, Danuše Lefnerová, Jan Strohalm, Naděžda Vrchotová, Ondřej Zendulka, Jiřina Průchová, Jana Chaloupková, Pavla Novotná, Milan Houška   +9 more
doaj   +1 more source

Geraniol treatment enhances sulforaphane content through modulation of the glucosinolate biosynthetic pathway in kale (Brassica oleracea)

Applied Biological Chemistry
Kale (Brassica oleracea) is a cruciferous vegetable known for health benefits, primarily due to sulforaphane, a compound with notable anticancer properties.
Jong-Moon Ju, Heang-Lim Lee, Yu-Sin Jang, Jaeil Byeon   +3 more
doaj   +1 more source

Sulforaphane as a Promising Molecule for Fighting Cancer

, 2013
Cancer is a complex disease characterized by multiple genetic and molecular alterations involving transformation, deregulation of apoptosis, proliferation, invasion, angiogenesis, and metastasis. To grow, invade, and metastasize, tumors need host components and primary dysfunction in the tumor microenvironment, in addition to cell dysfunction, can be ...
LENZI, MONIA, FIMOGNARI, CARMELA, HRELIA, PATRIZIA   +2 more
openaire   +2 more sources

Optimization of the Extraction Process of Extract Containing Sulforaphane from Broccoli Seeds and Evaluation of Its Immunomodulatory Activity

Shipin gongye ke-ji
In order to investigate the optimal extraction process of sulforaphane from broccoli seeds and evaluate its immunomodulatory activity, broccoli seeds as the raw material, the effects of parameters including solid-liquid ratio, ethanol concentration ...
Wan TANG, Fuli LAI, Guifang HAO, Yang CHEN, Wanyin SHI, Suqin WANG, Zhe WANG, Qiang YANG, Jian XU   +8 more
doaj   +1 more source