Results 71 to 80 of about 22,428 (226)

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization [PDF]

, 2016
Scope: Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown adipose tissue dissipating energy to produce heat in mammals.
Bao, Yong P., Chen, Fen, Chen, Shi Y, Fu, Jian F, Shan, Yu J, Wang, An S, Yao, An J, Zhang, Hui Q, Zhang, Xiao H, Zhao, Jin S, Zhou, Zu Q   +10 more
core   +1 more source

1,2,6‐Thiadiazin‐4‐ones: Robust Photocatalysts for the Green Aerobic Oxidation of Sulfides to Sulfoxides

European Journal of Organic Chemistry, EarlyView.
A new photocatalyst for the aerobic photochemical oxidation of sulfides to sulfoxides is described under really low catalyst loading (0.01 mol%) and methanol as the green solvent. The chemoselective oxidation of sulfides to sulfoxides is accomplished using a new family of photocatalysts, namely 1,2,6‐thiadiazin‐4‐ones. Utilizing a low catalyst loading (
Charikleia I. Karaousta, Stamatis K. Serviou, Chrysanthi K. Spyropoulou, Nikolaos Stavridis, Andreas S. Kalogirou, Panayiotis A. Koutentis, Christoforos G. Kokotos   +6 more
wiley   +1 more source

Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase. [PDF]

PLoS ONE, 2015
Glucoraphanin from broccoli and its sprouts and seeds is a water soluble and relatively inert precursor of sulforaphane, the reactive isothiocyanate that potently inhibits neoplastic cellular processes and prevents a number of disease states ...
Jed W Fahey, W David Holtzclaw, Scott L Wehage, Kristina L Wade, Katherine K Stephenson, Paul Talalay   +5 more
doaj   +1 more source

Sulforaphane reduces obesity by reversing leptin resistance

eLife, 2022
The ascending prevalence of obesity in recent decades is commonly associated with soaring morbidity and mortality rates, resulting in increased health-care costs and decreased quality of life.
Işın Çakır, Pauline Lining Pan, Colleen K Hadley, Abdulrahman El-Gamal, Amina Fadel, Dina Elsayegh, Omnia Mohamed, Nasser M Rizk, Masoud Ghamari-Langroudi   +8 more
doaj   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Sulforaphane Target Protein Prediction: A Bioinformatics Analysis

Applied Sciences
Sulforaphane, a phytochemical found in cruciferous vegetables and various nutraceutical foods, plays a crucial role in promoting well-being and combating various diseases.
Francisco Alejandro Lagunas-Rangel
doaj   +1 more source

Glutathione Biosynthesis via Activation of the Nuclear Factor E2–Related Factor 2 (Nrf2) – Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate

Journal of Pharmacological Sciences, 2011
Oxidative stress plays pivotal roles in aging, neurodegenerative disease, and pathological conditions such as ischemia. We investigated the effect of sulforaphane and 6-(methysulfinyl) hexyl isothiocyanate (6-HITC), a naturally occurring isothiocyanate ...
Keita Mizuno, Toshiaki Kume, Chie Muto, Yuki Takada-Takatori, Yasuhiko Izumi, Hachiro Sugimoto, Akinori Akaike   +6 more
doaj   +1 more source

Novel targets of sulforaphane in primary cardiomyocytes identified by proteomic analysis. [PDF]

PLoS ONE, 2013
Cardiovascular diseases represent the main cause of mortality in the industrialized world and the identification of effective preventive strategies is of fundamental importance.
Cristina Angeloni, Silvia Turroni, Laura Bianchi, Daniele Fabbri, Elisa Motori, Marco Malaguti, Emanuela Leoncini, Tullia Maraldi, Luca Bini, Patrizia Brigidi, Silvana Hrelia   +10 more
doaj   +1 more source

Therapeutic effects of sulforaphane in ulcerative colitis: effect on antioxidant activity, mitochondrial biogenesis and DNA polymerization

Redox Report, 2022
Objectives Ulcerative colitis (UC), an inflammatory bowel disease, affects mucosal lining of colon leading to inflammation and ulcers. Sulforaphane is a natural compound obtained from cruciferous vegetables.
Abdullah Alattar, Reem Alshaman, Mohammed M. H. Al-Gayyar   +2 more
doaj   +1 more source