Results 51 to 60 of about 12,016 (182)
Horticultural Plant JournalSulforaphane, a naturally specialized metabolite, plays significant roles in human disease prevention and plant defense. Myrosinase (MY) is a key gene responsible for the catalysis of sulforaphane formation, but the molecular mechanisms through which MY ...
Qiuyun Wu +6 more
doaj +1 more source
Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase. [PDF]
PLoS ONE, 2015 Glucoraphanin from broccoli and its sprouts and seeds is a water soluble and relatively inert precursor of sulforaphane, the reactive isothiocyanate that potently inhibits neoplastic cellular processes and prevents a number of disease states ...
Jed W Fahey +5 more
doaj +1 more source
Microbiome–Driven Carcinogenesis and Circulating Microbial Signals in Genitourinary Cancers
Cancer Science, EarlyView.Experimental BBN models link gut microbial metabolism and diet‐microbiome interactions to urothelial carcinogenesis, while circulating extracellular vesicle‐associated bacterial DNA signals may reflect tumor immune contexture and immune checkpoint inhibitor outcomes in urothelial and renal cell carcinoma.
Atsunari Kawashima +12 more
wiley +1 more source
Journal of Pharmacological Sciences, 2011 Oxidative stress plays pivotal roles in aging, neurodegenerative disease, and pathological conditions such as ischemia. We investigated the effect of sulforaphane and 6-(methysulfinyl) hexyl isothiocyanate (6-HITC), a naturally occurring isothiocyanate ...
Keita Mizuno +6 more
doaj +1 more source
Novel targets of sulforaphane in primary cardiomyocytes identified by proteomic analysis. [PDF]
PLoS ONE, 2013 Cardiovascular diseases represent the main cause of mortality in the industrialized world and the identification of effective preventive strategies is of fundamental importance.
Cristina Angeloni +10 more
doaj +1 more source
Sulforaphane reduces obesity by reversing leptin resistance
eLife, 2022 The ascending prevalence of obesity in recent decades is commonly associated with soaring morbidity and mortality rates, resulting in increased health-care costs and decreased quality of life.
Işın Çakır +8 more
doaj +1 more source
Stimulating proteasomal degradation in human proteinopathies
The FEBS Journal, EarlyView.The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch +2 more
wiley +1 more source
Interaction of Sulforaphane with DNA and RNA
PLOS ONE, 2015 Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables with anti-inflammatory, anti-oxidant and anti-cancer activities. However, the antioxidant and anticancer mechanism of sulforaphane is not well understood. In the present research, we reported binding modes, binding constants and stability of SFN-DNA and -RNA complexes by Fourier ...
Farzaneh Abassi Joozdani +3 more
openaire +4 more sources
Sulforaphane in experimental hypertension
Libyan International Medical University Journal, 2020 Abstract Background: Hypertension is defined as a failure to achieve a blood pressure (BP) target – smaller than 140/90 mmHg. The worldwide burden of hypertension has been associated with globally increased rates of death and disability. There is increasing evidence of strong relation between hypertension and oxidative stress, where either ...
Ali Banigesh +3 more
openaire +2 more sources
Redox Report, 2022 Objectives Ulcerative colitis (UC), an inflammatory bowel disease, affects mucosal lining of colon leading to inflammation and ulcers. Sulforaphane is a natural compound obtained from cruciferous vegetables.
Abdullah Alattar +2 more
doaj +1 more source