Results 51 to 60 of about 22,428 (226)

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom [PDF]

, 2018
Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these ...
Arnold, Walter, Johnson, Richard J., Kuro-o, Makoto, Lanaspa, Miguel, Painer, Johanna, Ruf, Thomas, Shiels, Paul G., Stenvinkel, Peter   +7 more
core   +1 more source

Anticancer properties of sulforaphane: current insights at the molecular level

Frontiers in Oncology, 2023
Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature ...
Muhammad Asif Ali, Noohela Khan, Nabeeha Kaleem, Waqas Ahmad, Salem Hussain Alharethi, Bandar Alharbi, Hassan H. Alhassan, Maher M. Al-Enazi, Ahmad Faizal Abdull Razis, Ahmad Faizal Abdull Razis, Babagana Modu, Babagana Modu, Daniela Calina, Javad Sharifi-Rad   +13 more
doaj   +1 more source

Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis [PDF]

, 2017
Osteoarthritis (OA), affecting joints and bone, causes physical gait disability with huge socio-economic burden; treatment remains palliative. Roles for antioxidants in protecting against such chronic disorders have been examined previously. Sulforaphane
Ahmed Aljazzar, Alam, Andrea Pollard, Andrew A. Pitsillides, Behzad Javaheri, Bellido, Blandine Poulet, Boris Chan, Brewster, Carbone, Castañeda, Chambers, Chambers, Chiusaroli, Christiansen, Clarke, Conaghan, Custers, Davidson, Davidson, Doube, Duarte, Elaine Shervill, Foster, Glasson, Glasson, Goldring, Goldring, Haseeb, Hayami, Henrotin, Ho, Hochman, Isabel R. Orriss, Javaheri, Javaheri, Juge, Juhl, Karsdal, Kim, Li, Little, Lo, Mark Hopkinson, Mason, Miriam Piles, Mündermann, Pasold, Pastoureau, Pauli, Pearson, Peter D. Lee, Piles, Poulet, Poulet, Poulet, Poulet, Poulet, Pritzker, Radin, Roberto de Souza, Scheller, Schnitzer, Tat, Taylor, Thaler, Uchida, Valdes, Vincelette, Wang, Wu, Xiao, Yu-Mei Chang, Zakkar   +73 more
core   +3 more sources

Sulforaphane and ophthalmic diseases

Food Science & Nutrition
AbstractSulforaphane (SFN) is an organosulfur compound categorized as an isothiocyanate (ITC), primarily extracted from cruciferous vegetables like broccoli and cabbage. The molecular formula of sulforaphane (SFN) is C6H11NOS2. SFN is generated by the hydrolysis of glucoraphanin (GRP) through the enzyme myrosinase, showing notable properties including ...
Yichi Zhang, Xiaojing Zhao, Yang Liu, Xiuxia Yang   +3 more
openaire   +2 more sources

Microwave cooking increases sulforaphane level in broccoli [PDF]

Food Science & Nutrition, 2020
AbstractSulforaphane (SFR), an anticarcinogenic compound, forms from the hydrolysis of glucoraphanin (GLR) in broccoli. Cooking methods have been shown to affect broccoli GLR and SFR levels, but little is known about the effect of lightly cooking processes on them.
Yingjian Lu, Xinyi Pang, Tianbao Yang
openaire   +3 more sources

Glucoraphanin conversion into sulforaphane and related compounds by gut microbiota

Frontiers in Physiology
Glucosinolate glucoraphanin, common in cruciferous vegetables, is a biologically stable precursor of isothiocyanates, such as sulforaphane and erucin, potent activators of Nrf2 signaling coordinating an adaptive response to oxidative stress. Sulforaphane
Tetiana R. Dmytriv, Tetiana R. Dmytriv, Oleh Lushchak, Oleh Lushchak, Volodymyr I. Lushchak, Volodymyr I. Lushchak   +5 more
doaj   +1 more source

Bioavailability of Glucoraphanin and Sulforaphane From High-Glucoraphanin Broccoli [PDF]

, 2018
Scope: Broccoli accumulates 4-methylsulphinylbutyl glucosinolate (glucoraphanin) which is hydrolyzed to the isothiocyanate sulforaphane. Through the introgression of novel alleles of the Myb28 transcription factor from Brassica villosa, broccoli ...
Al Janobi, Aune, Clarke, Clarke, Cotton, Covault, Fuentes, Gasper, Gigolashvili, Juge, Kassahun, Liu, Liu, Luang-In, Mithen, Saha, Sonderby, Thomson, Traka, Tse, Vermeulen, Wu, Zhang   +22 more
core   +1 more source

Sulforaphane attenuates EGFR signaling in NSCLC cells [PDF]

Journal of Biomedical Science, 2015
EGFR, a receptor tyrosine kinase (RTK), is frequently overexpressed and mutated in non-small cell lung cancer (NSCLC). Tyrosine kinase inhibitors (TKIs) have been widely used in the treatment of many cancers, including NSCLC. However, intrinsic and acquired resistance to TKI remains a common obstacle.
Chen, Chi-Yuan, Yu, Zhu-Yun, Chuang, Yen-Shu, Huang, Rui-Mei, Wang, Tzu-Chien V   +4 more
openaire   +2 more sources

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

Advanced Science, EarlyView.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei, Wei Liu, Bili Cao, Dan Zhao, Chengqiang Wang, Xin Hou, Tangyuan Ning, Biao Gong   +7 more
wiley   +1 more source

Nutrigenomics: Using Sulforaphane Consumption as a Mechanism to Prevent Cardiovascular Disease through Epigenetic Regulation [PDF]

, 2018
Cardiovascular disease is the leading cause of death in the United States. Diet composition and reduced expression of the transcription factor Nrf2 are both possible factors contributing to cardiovascular disease.
Agrawal, Alisha
core   +1 more source