Results 41 to 50 of about 11,962 (184)
Frontiers in Cell and Developmental Biology, 2021 Broccoli-derived isothiocyanate sulforaphane inhibits inflammation and cancer. Sulforaphane may support healthy aging, but the underlying detailed mechanisms are unclear. We used the C. elegans nematode model to address this question.
Huihui Ji +9 more
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Exploring the anti‐inflammatory activity of sulforaphane
Immunology & Cell Biology, 2023 AbstractDysregulation of innate immune responses can result in chronic inflammatory conditions. Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but come with a trade‐off of cumulative and serious side effects. Therefore, alternative drug options with improved safety profiles are urgently needed.
Katie Treasure +2 more
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Stimulation of Suicidal Erythrocyte Death by Sulforaphane [PDF]
Basic & Clinical Pharmacology & Toxicology, 2014 AbstractSulforaphane, an isothiocyanate from cruciferous vegetable, counteracts malignancy. The effect is at least in part due to the stimulation of suicidal death or apoptosis of tumour cells. Mechanisms invoked in sulforaphane‐induced apoptosis include mitochondrial depolarization and altered gene expression.
Alzoubi K. +3 more
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浙江大学学报. 农业与生命科学版, 2013 Sulforaphane (SFN) is an isothiocyanate (ITC) which exists as a precursor of glucosinolate (GS) in various cruciferous vegetables especially in broccoli. Sulforaphane has been regarded as a potential of anti-cancer agent derived from diet, mostly because
LI Baolong +5 more
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Sulforaphane in experimental hypertension
Libyan International Medical University Journal, 2020 Abstract Background: Hypertension is defined as a failure to achieve a blood pressure (BP) target – smaller than 140/90 mmHg. The worldwide burden of hypertension has been associated with globally increased rates of death and disability. There is increasing evidence of strong relation between hypertension and oxidative stress, where either ...
Ali Banigesh +3 more
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Interaction of Sulforaphane with DNA and RNA
PLOS ONE, 2015 Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables with anti-inflammatory, anti-oxidant and anti-cancer activities. However, the antioxidant and anticancer mechanism of sulforaphane is not well understood. In the present research, we reported binding modes, binding constants and stability of SFN-DNA and -RNA complexes by Fourier ...
Farzaneh Abassi Joozdani +3 more
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Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma [PDF]
BMB Reports, 2012 Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)-butane), belongingto a family of natural compounds that are abundant in broccoli,has received significant therapeutic interest in recent years.However, the molecular basis of its effects remains to ...
Jun Ho Park +11 more
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Anticancer properties of sulforaphane: current insights at the molecular level
Frontiers in Oncology, 2023 Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature ...
Muhammad Asif Ali +13 more
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Broccoli for the brain: a review of the neuroprotective mechanisms of sulforaphane
Frontiers in Cellular NeuroscienceSulforaphane, a phytochemical abundant in the sprouts of cruciferous vegetables, protects plants during a critical period of development. Through sulforaphane’s ability to activate the mammalian Nuclear Factor Erythroid 2-related Factor 2 (NRF2) pathway,
Riley N. Bessetti +3 more
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D, L-Sulforaphane Loaded Fe3O4@ Gold Core Shell Nanoparticles: A Potential Sulforaphane Delivery System. [PDF]
PLoS ONE, 2016 A novel design of gold-coated iron oxide nanoparticles was fabricated as a potential delivery system to improve the efficiency and stability of d, l-sulforaphane as an anticancer drug.
Hamidreza Kheiri Manjili +5 more
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