Results 41 to 50 of about 22,428 (226)
Characterization of theThreshold for NAD(P)H:quinone Oxidoreductase Activity in Intact Sulforaphane-treated Pulmonary Arterial Endothelial Cells [PDF]
, 2011 Treatment of bovine pulmonary arterial endothelial cells in culture with the phase II enzyme inducer sulforaphane (5 μM, 24 h; sulf-treated) increased cell-lysate NAD(P)H:quinone oxidoreductase (NQO1) activity by 5.7 ± 0.6 (mean ± SEM)-fold, but intact ...
Bongard, Robert D. +5 more
core +2 more sources
Stability of sulforaphane for topical formulation [PDF]
Drug Development and Industrial Pharmacy, 2013 Sulforaphane (SFN) is a natural compound that has been investigated as a chemopreventive agent. SFN has been shown to inhibit the activator-protein-1 (AP-1) transcription factor and may be effective for inhibition of ultraviolet (UV) induced skin carcinogenesis.
Stephen J, Franklin +4 more
openaire +2 more sources
NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]
, 2018 Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena +19 more
core +1 more source
Prion degradation pathways: Potential for therapeutic intervention [PDF]
, 2015 Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrP(C) into the disease-associated form PrP(Sc) that accumulates in the brain as disease progresses. Although treatments have yet to be
Goold, R, McKinnon, C, Tabrizi, SJ
core +1 more source
Sulforaphane improves cognitive function administered following traumatic brain injury. [PDF]
, 2009 Recent studies have shown that sulforaphane, a naturally occurring compound that is found in cruciferous vegetables, offers cellular protection in several models of brain injury.
Dash, Pramod K +4 more
core +1 more source
Exploring the anti‐inflammatory activity of sulforaphane
Immunology & Cell Biology, 2023 AbstractDysregulation of innate immune responses can result in chronic inflammatory conditions. Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but come with a trade‐off of cumulative and serious side effects. Therefore, alternative drug options with improved safety profiles are urgently needed.
Katie Treasure +2 more
openaire +3 more sources
浙江大学学报. 农业与生命科学版, 2013 Sulforaphane (SFN) is an isothiocyanate (ITC) which exists as a precursor of glucosinolate (GS) in various cruciferous vegetables especially in broccoli. Sulforaphane has been regarded as a potential of anti-cancer agent derived from diet, mostly because
LI Baolong +5 more
doaj +1 more source
Sulforaphane - role in aging and neurodegeneration [PDF]
GeroScience, 2019 In the last several years, numerous molecules derived from plants and vegetables have been tested for their antioxidant, anti-inflammatory, and anti-aging properties. One of them is sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables.
Santín-Márquez R. +4 more
openaire +3 more sources
Stimulation of Suicidal Erythrocyte Death by Sulforaphane [PDF]
Basic & Clinical Pharmacology & Toxicology, 2014 AbstractSulforaphane, an isothiocyanate from cruciferous vegetable, counteracts malignancy. The effect is at least in part due to the stimulation of suicidal death or apoptosis of tumour cells. Mechanisms invoked in sulforaphane‐induced apoptosis include mitochondrial depolarization and altered gene expression.
Alzoubi K. +3 more
openaire +4 more sources
Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma [PDF]
BMB Reports, 2012 Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)-butane), belongingto a family of natural compounds that are abundant in broccoli,has received significant therapeutic interest in recent years.However, the molecular basis of its effects remains to ...
Jun Ho Park +11 more
doaj +1 more source