Results 21 to 30 of about 16,993 (221)

Xenobiotic Sulforaphane in Head and Neck Cancer: Beyond the Nrf2 Pathway [PDF]

Journal of Xenobiotics
Head and neck cancers (HNCs) represent a major global health burden and remain associated with substantial morbidity and limited therapeutic options, particularly in advanced or recurrent disease.
Alessandro Polizzi, Rossella Rotondo, Sabrina Donati Zeppa, Monia Cecati, Magdalena Smolik, Valentina Schiavoni, Angelo Montana, Valentina Pozzi, Davide Sartini, Roberto Campagna, Gaetano Isola   +10 more
doaj   +2 more sources

Sulforaphane as a Therapeutic Target for Sarcopenia in Type 2 Diabetes: Mechanistic Insights and Translational Evidence [PDF]

Antioxidants
Sulforaphane, a bioactive isothiocyanate abundant in cruciferous vegetables, has emerged as a potential multi-target therapeutic agent capable of mitigating these pathological processes.
Ayanda Ngcobo, Samukelisiwe C. Shabalala, Nokulunga Hlengwa, Ndivhuwo Muvhulawa, Patrick Orlando, Sonia Silvestri, Luca Tiano, Phiwayinkosi V. Dludla   +7 more
doaj   +2 more sources

Sulforaphane: a natural organosulfur having potential to modulate apoptosis and survival signalling in cancer

Discover Oncology
Owing to its ever-growing range of pharmacological advantages, sulforaphane, an isothiocyanate from cruciferous vegetables such as broccoli, is becoming increasingly popular.
Hemant Joshi, Isha Rani, Vikas Sharma, Ujjawal Sharma, Tanisha Dimri, Manoj Kumar, Ritu Chauhan, Abhishek Chauhan, Damandeep Kaur, Shafiul Haque, Faraz Ahmad, Hardeep Singh Tuli   +11 more
doaj   +2 more sources

Inhibition of pancreatic cancer progression by sulforaphane-mediated downregulation of miR30a-3p and sulforaphane derivatives [PDF]

, 2021
PDA is one of the deadliest cancers with poor prognosis and profound therapy resistance, which is associated with the loss of gap junctional intercellular communication and Cx43 expression. A promising bioactive agent with multiple anti-cancer activities
Georgikou, Christina
core   +1 more source

Effect of a sulforaphane supplement on muscle soreness and damage induced by eccentric exercise in young adults: A pilot study

Physiological Reports, 2021
Objective Excessive exercise increases the production of reactive oxygen species in skeletal muscles. Sulforaphane activates nuclear factor erythroid 2‐related factor 2 (Nrf2) and induces a protective effect against oxidative stress.
Shoichi Komine, Ikuru Miura, Nao Miyashita, Sechang Oh, Katsuyuki Tokinoya, Junichi Shoda, Hajime Ohmori   +6 more
doaj   +1 more source

Sulforaphane modulates TGFβ2-induced conjunctival fibroblasts activation and fibrosis by inhibiting PI3K/Akt signaling [PDF]

International Journal of Ophthalmology, 2020
AIM: To examine the effects of sulforaphane on fibrotic changes of transforming growth factor (TGFβ2) induced human conjunctival fibroblast (HConFs).
Han-Ruo Liu, Zi-Yao Xia, Ning-Li Wang
doaj   +1 more source

Sulforaphane is anticonvulsant and improves mitochondrial function [PDF]

, 2015
The nuclear factor erythroid 2-related factor 2 pathway (Nrf2) has been previously identified to protect the brain against various impacts. Here, we investigated the effect of the Nrf2 activator sulforaphane in various seizure models and hippocampal ...
Carrasco-Pozo, Catalina, Borges, Karin, Kah, Ni Tan   +2 more
core   +2 more sources

Helicobacter pylori Outer Membrane Vesicles Engage TLR2 Through NapA to Promote Epithelial Association and Inflammatory Signalling. [PDF]

J Extracell Vesicles
ABSTRACT Helicobacter pylori infection is characterized by chronic gastric inflammation driven by persistent activation of innate immune signaling pathways. Outer membrane vesicles (OMVs) released by H. pylori are important mediators of host–pathogen interactions.
Rubilar M, Brito R, Palavecino A, Villena J, Mellado M, Silva MI, Valenzuela-Valderrama M.   +6 more
europepmc   +2 more sources

Studies on exogenous elicitors promotion of sulforaphane content in broccoli sprouts and its effect on the MDA-MB-231 breast cancer cell line

Annals of Agricultural Sciences, 2021
Broccoli (Brassica oleracea var. italica) belongs to the Brassicaceae family and is one of the most important cruciferous vegetables. It has gained popularity due to its high glucosinolate concentrations that have positive potential in cancer treatment ...
May Ahmed Amer, Thoria Rashad Mohamed, Raoufa A. Abdel Rahman, Manal Ali, Abdelfattah Badr   +4 more
doaj   +1 more source

Stimulation of phagocytosis by sulforaphane [PDF]

Biochemical and Biophysical Research Communications, 2011
Sulforaphane, a major isothiocyanate derived from cruciferous vegetables, protects living systems against electrophile toxicity, oxidative stress, inflammation, and radiation. A major protective mechanism is the induction of a network of endogenous cytoprotective (phase 2) genes that are regulated by transcription factor Nrf2. To obtain a more detailed
Hiroyuki, Suganuma, Jed W, Fahey, Kelley E, Bryan, Zachary R, Healy, Paul, Talalay   +4 more
openaire   +2 more sources