Results 31 to 40 of about 16,517 (209)

Effect of Storage Conditions and Cooking Methods on Chlorophyll, Glucosinolate, and Sulforaphane Content in Broccoli Florets

Horticulturae, 2021
The effects of storage conditions and cooking methods on chlorophyll, glucosinolate (GSL), and sulforaphane content in broccoli florets were investigated in this study.
Junwei Wang, Shuxiang Mao, Yiming Yuan, Na Zhang, Qi Wu, Mantian Liang, Shengze Wang, Ke Huang, Qiuyun Wu   +8 more
doaj   +1 more source

Natural Sulforaphane From Broccoli Seeds Against Influenza A Virus Replication in MDCK Cells

Natural Product Communications, 2019
We explored the potential application of sulforaphane against influenza A virus and elucidated the underlying cytopathic effect (CPE) and cytotoxicity. In the present study, 2 sulforaphane products were used to investigate the CPEs on influenza A virus ...
Zhansheng Li, Yumei Liu, Zhiyuan Fang, Limei Yang, Mu Zhuang, Yangyong Zhang, Honghao Lv   +6 more
doaj   +1 more source

Sulforaphane-driven reprogramming of gut microbiome and metabolome ameliorates the progression of hyperuricemia

Journal of Advanced Research, 2023
Introduction: Currently, revealing how to prevent and control hyperuricemia has become an essential public health issue. Sulforaphane has a wide range of applications in the management of hyperuricemia.
Ruoyu Wang, Mairepaiti Halimulati, Xiaojie Huang, Yuxin Ma, Lutong Li, Zhaofeng Zhang   +5 more
doaj   +1 more source

Sulforaphanes: disruptors of phagophores and autolysosomes

Autophagy Reports, 2022
Sulforaphane and its metabolites (SFNs) cause apoptosis in cancers and could be potential anti-cancer drugs. We focused on investigating the underlying mechanisms through which SFNs inhibit cancers. First, SFNs cause microtubule disruption by phosphorylated MAPK1/ERK2-MAPK3/ERK1-mediated activation of 26S proteasome leading to a microtubule-associated ...
Yan Zhou, Wei Wu
openaire   +3 more sources

The emerging role of Nrf2 in mitochondrial function [PDF]

, 2015
The transcription factor NF-E2 p45-related factor 2 (Nrf2, gene name NFE2L2) allows adaptation and survival under conditions of stress by regulating the gene expression of diverse networks of cytoprotective proteins, including antioxidant, anti ...
Dinkova-Kostova, AT, Abramov, Andrey Y., Dinkova-Kostova, Albena T.; id_orcid, Abramov, AY, Dinkova-Kostova, Albena T.   +4 more
core   +1 more source

Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids [PDF]

, 2014
The transcription factor Nrf2 protects against a number of experimental pathologies, and is a promising therapeutic target. The clinical investigation of a potent Nrf2-inducing agent, the triterpenoid (TP) bardoxolone methyl (BARD), was recently halted ...
Lister, Adam, Shelton, Luke M., Kratschmar, Denise V., Copple, Ian M., Park, B. Kevin, Goldring, Christopher E., Honda, Tadashi, Odermatt, Alex, Walsh, Joanne, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T.   +10 more
core   +1 more source

Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane. [PDF]

PLoS ONE, 2012
Sulforaphane-induced activation of the transcription factor NF-E2 related factor 2 (Nrf2 or the gene Nfe2l2) and subsequent induction of the phase II antioxidant system has previously been shown to exert neuroprotective action in a transient model of ...
Michelle J Porritt, Helene C Andersson, Linda Hou, Åsa Nilsson, Marcela Pekna, Milos Pekny, Michael Nilsson   +6 more
doaj   +1 more source

Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate [PDF]

, 2008
Epidemiological studies suggest that people who consume more than one portion of cruciferous vegetables per week are at lower risk of both the incidence of prostate cancer and of developing aggressive prostate cancer but there is little understanding of ...
Richard Y Ball, Amy V Gasper, David A Barrett, Catharine A. Ortori, Richard F Mithen, Richard F. Mithen, Catharine A Ortori, Amy V. Gasper, Paul W. Needs, Traka, Maria H., Maria Traka, Ball, Richard Y., Traka, Maria, Barrett, David A., David A. Barrett, Jones, Alexandra M. E., Antonietta Melchini, Chantry, Andrew, Ortori, Catharine A., Bacon, James R., Mills, Robert D., Richard Y. Ball, Melchini, Antonietta, Frost, Victoria, Victoria Frost, Paul W Needs, Robert D. Mills, Needs, Paul W., James R. Bacon, James R Bacon, Jones, Alexandra M., Gasper, Amy V., Alexandra M. E. Jones, Andrew Chantry, Alexandra M E Jones, Mithen, Richard F., Robert D Mills   +36 more
core   +1 more source

Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction

Journal of the Formosan Medical Association, 2017
Background/Purpose: Cancer stem cells (CSCs) are deemed as the driving force of tumorigenesis in oral squamous cell carcinomas (OSCCs). In this study, we investigated the chemotherapeutic effect of sulforaphane, a dietary component from broccoli sprouts,
Chia-Ming Liu, Chih-Yu Peng, Yi-Wen Liao, Ming-Yi Lu, Meng-Lun Tsai, Jung-Chun Yeh, Chuan-Hang Yu, Cheng-Chia Yu   +7 more
doaj   +1 more source

The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory cytokines.

PLoS ONE, 2021
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an important transcription factor that plays a pivotal role in cellular defense against oxidative injury.
Su-Jin Moon, Jooyeon Jhun, Jaeyoon Ryu, Ji Ye Kwon, Se-Young Kim, KyoungAh Jung, Mi-La Cho, Jun-Ki Min   +7 more
doaj   +1 more source