Results 81 to 90 of about 11,962 (184)

Solanesol Alleviates Perfluoroheptanoic Acid‐Induced Premature Senescence in Human Skin Fibroblasts via RNA Methylation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Perfluoroheptanoic acid (PFHpA) induces premature senescence in normal human skin fibroblasts (HSFs), as characterized by decreased cell viability, increased SA‐β‐gal staining, impaired wound healing, cell cycle dysregulation, elevated ROS levels, and upregulated SASP mRNA expression.
Jiaqi Fu, Tingting Huang, Guisong Li, Xinyu Zhang, Luyi Tan, Chenyu Zhu, Wenji Zhang, Wenjuan Zhang   +7 more
wiley   +1 more source

Sulforaphane regulates AngII-induced podocyte oxidative stress injury through the Nrf2-Keap1/ho-1/ROS pathway

Renal Failure
Objective This study aimed to investigate the therapeutic effects of sulforaphane and the role of the Nrf2-Keap1/HO-1/ROS pathway in AngII-induced oxidative stress in podocyte injury.Methods Mouse mpc5 podocytes were divided into four groups: control ...
Wen Lu
doaj   +1 more source

Sulforaphane Attenuates Endometriosis in Rat Models Through Inhibiting PI3K/Akt Signaling Pathway

Dose-Response, 2019
Sulforaphane exerts anti-inflammatory activity in inflammatory diseases. The endometriosis (EM) is accompanied by chronic inflammation. The present study aims to explore the therapeutic effects of sulforaphane on EM and its underlying mechanism.
Aixiu Zhou, Yiting Hong, Yuchun Lv
doaj   +1 more source

Sulforaphane as a preventive agent in Oral Cancer- A Systematic Review

Oral Oncology Reports
Background: Cancer is one of the leading causes of death worldwide. Of these, oral cancer is the sixth most common malignancy. Several phytochemicals are emerging these days in prevention of oral cancer. Sulforaphane present in broccoli is one such agent
M. Parasakthi, Kavitha Sanjeev
doaj   +1 more source

Transcriptome reveals the gene expression patterns of sulforaphane metabolism in broccoli florets.

PLoS ONE, 2019
Sulforaphane is a new and effective anti-cancer component that is abundant in broccoli. In the past few years, the patterns of variability in glucosinolate content and its regulation in A. thaliana have been described in detail. However, the diversity of
Zhansheng Li, Yumei Liu, Lingyun Li, Zhiyuan Fang, Limei Yang, Mu Zhuang, Yangyong Zhang, Honghao Lv   +7 more
doaj   +1 more source

Sulforaphane as a Promising Molecule for Fighting Cancer

, 2013
Cancer is a complex disease characterized by multiple genetic and molecular alterations involving transformation, deregulation of apoptosis, proliferation, invasion, angiogenesis, and metastasis. To grow, invade, and metastasize, tumors need host components and primary dysfunction in the tumor microenvironment, in addition to cell dysfunction, can be ...
LENZI, MONIA, FIMOGNARI, CARMELA, HRELIA, PATRIZIA   +2 more
openaire   +2 more sources

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

MedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao   +12 more
wiley   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Sulforaphane: a natural organosulfur having potential to modulate apoptosis and survival signalling in cancer

Discover Oncology
Owing to its ever-growing range of pharmacological advantages, sulforaphane, an isothiocyanate from cruciferous vegetables such as broccoli, is becoming increasingly popular.
Hemant Joshi, Isha Rani, Vikas Sharma, Ujjawal Sharma, Tanisha Dimri, Manoj Kumar, Ritu Chauhan, Abhishek Chauhan, Damandeep Kaur, Shafiul Haque, Faraz Ahmad, Hardeep Singh Tuli   +11 more
doaj   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source