Results 81 to 90 of about 16,993 (221)
Metabolic reprogramming of the immune response in periodontitis
Periodontology 2000, EarlyView.Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon +3 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract (Poly)phenols are a diverse group of bioactive chemical compounds present in a wide range of plant‐ and animal‐based foods. Several thousands of (poly)phenols exist; many have potent biological effects, most notably antioxidant, anti‐inflammatory and vasodilatory.
Glyn Howatson, Tom Clifford
wiley +1 more source
Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
, 2017 n the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate derived from glucoraphanin, occurring in large amounts in Brassica genus plants.
Daglia, Maria +15 more
core +1 more source
Journal of Pharmacological Sciences, 2011 Oxidative stress plays pivotal roles in aging, neurodegenerative disease, and pathological conditions such as ischemia. We investigated the effect of sulforaphane and 6-(methysulfinyl) hexyl isothiocyanate (6-HITC), a naturally occurring isothiocyanate ...
Keita Mizuno +6 more
doaj +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.Tumor‐derived exosomal factors prime cardiomyocytes for ferroptosis by suppressing the GPX4–SLC7A11–Nrf2 antioxidant axis, depleting glutathione, and promoting iron‐dependent lipid peroxidation. While PD‐1 blockade alone induces only mild oxidative stress, it acts synergistically with tumor signals to markedly amplify ferroptosis, leading to ...
Xiaohua Ma +5 more
wiley +1 more source
Sulforaphane Attenuates Endometriosis in Rat Models Through Inhibiting PI3K/Akt Signaling Pathway
Dose-Response, 2019 Sulforaphane exerts anti-inflammatory activity in inflammatory diseases. The endometriosis (EM) is accompanied by chronic inflammation. The present study aims to explore the therapeutic effects of sulforaphane on EM and its underlying mechanism.
Aixiu Zhou, Yiting Hong, Yuchun Lv
doaj +1 more source
Sepsis: Epidemiology, Pathophysiology, and Management
MedComm, Volume 7, Issue 11, November 2026.Sepsis remains a major global health burden characterized by substantial geographical heterogeneity and a considerable disease burden in China. Its pathophysiology reflects an interconnected network involving excessive inflammation, oxidative stress, immune imbalance and immunoparalysis, mitochondrial damage, endothelial injury, gut dysbiosis ...
Guang‐Tao Pan +8 more
wiley +1 more source
Thiol-reducing agents prevent sulforaphane-induced growth inhibition in ovarian cancer cells
, 2019 The inhibitory potential of sulforaphane against cancer has been suggested for different types of cancer, including ovarian cancer. We examined whether this effect is mediated by mitogen-activated protein kinase (MAPK) and reactive oxygen species (ROS ...
김승철, 권영주
core +1 more source
An Ultra-Performance Liquid Chromatoghraphy-Tandem Mass Spectrometry (UPLC-MS/MS) Method for the Rapid and Sensitive Determination of Sulforaphane and Sulforaphane Nitrile in Brassica Vegetables [PDF]
, 2013 A rapid UPLC-MS/MS method has been developed and validated for the simultaneous analysis of sulforaphane and sulforaphane nitrile from Brassica Oleracea L.
Valverde, Juan +4 more
core +1 more source
Renal FailureObjective This study aimed to investigate the therapeutic effects of sulforaphane and the role of the Nrf2-Keap1/HO-1/ROS pathway in AngII-induced oxidative stress in podocyte injury.Methods Mouse mpc5 podocytes were divided into four groups: control ...
Wen Lu
doaj +1 more source