Results 101 to 110 of about 16,993 (221)

Advanced Glycation End Products: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
Therapeutic landscape of AGE‐targeted intervention. Schematic representation of intervention strategies targeting distinct stages of AGE biology. Upstream prevention aims to reduce exposure and formation through low‐AGE cooking, smoking cessation, glycemic control, and metabolic optimization.
Tak‐Ho Lo, Junying Zou, Jingyi Zhang, Kaijun Lin, Minhui Zhu, Shuangqi Lu, Xin Liu, Mengyao Wu   +7 more
wiley   +1 more source

Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids [PDF]

, 2014
The transcription factor Nrf2 protects against a number of experimental pathologies, and is a promising therapeutic target. The clinical investigation of a potent Nrf2-inducing agent, the triterpenoid (TP) bardoxolone methyl (BARD), was recently halted ...
Lister, Adam, Shelton, Luke M., Kratschmar, Denise V., Copple, Ian M., Park, B. Kevin, Goldring, Christopher E., Honda, Tadashi, Odermatt, Alex, Walsh, Joanne, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T., Kratschmar DV, Walsh J, Park BK, Dinkova-Kostova AT, Odermatt A, Goldring CE, Copple IM, Lister A, Shelton LM, Honda T   +20 more
core   +1 more source

Receptor‐Targeted Niosomal Nanocarriers: Advances, Challenges, and Opportunities in Natural Compound Delivery for Cancer Therapy

Nano Select, Volume 7, Issue 10, October 2026.
Surface‐modified niosomes are introduced as multifunctional nanoparticles for precision tumor treatment that combine hydrophilic and lipophilic drug encapsulation with ligand‐based targeting via antibodies, peptides, transferrin, and folic acid. This modification leads to increased tumor selectivity, facilitates cell entry, and enables enhanced ...
Narges Sahraei, Aryan M. Faraj, Faezeh Molaei, Abolfazl Barzegar   +3 more
wiley   +1 more source

Sulforaphane modulates cell cycle and apoptosis in transformed and non-transformed human T lymphocytes.

, 2003
Isothiocyanates exert chemopreventive effects against chemically induced tumors in animals, modulating enzymes required for carcinogens' activation/detoxification and/or the induction of cell-cycle arrest and apoptosis in tumor cell lines.
Berti, F., Nüsse, M., Iori, R., MICHAEL NÜSSE, Cantelli-Forti, G., PATRIZIA HRELIA, GIORGIO CANTELLI‐FORTI, Fimognari, C., Hrelia, P., FAUSTO BERTI, CARMELA FIMOGNARI, RENATO IORI   +11 more
core   +1 more source

Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo [PDF]

, 2013
Sulforaphane (SFN) has been reported to regulate signaling pathways relevant to chronic diseases. The aim of this study was to investigate the impact of SFN treatment on signaling pathways in chondrocytes and to determine whether sulforaphane could block
Donell, Simon T., Culley, Kirsty L, Rose K. Davidson, Vincent, Tonia L., Kirsty L. Culley, Rachel de Ferrars, Yongping Bao, Colin D. Kay, Clark, Ian M., Bao, Yongping, Kay, Colin D., Clare Driscoll, Orla Jupp, Norton, Rosemary, Davidson, Rose K., Tonia L. Vincent, Jupp, Orla, de Ferrars, Rachel, Rosemary Norton, Simon T. Donell, Driscoll, Clare, Ian M. Clark   +21 more
core   +1 more source

Investigating Sulforaphane’s anti-virulence and anti-quorum sensing properties against Pseudomonas aeruginosa

Frontiers in Pharmacology
BackgroundP. aeruginosa, a significant bacterium, can cause severe illness and resistance to antibiotics. Quorum sensing (QS) systems regulate virulence factors production.
Mahmoud M. Bendary, Mohamed A. M. Ali, Mohamed A. M. Ali, Alyaa S. Abdel Halim, Fehmi Boufahja, Anis Ahmad Chaudhary, Amr Elkelish, Amr Elkelish, Rania H. M. Soliman, Wael A. H. Hegazy, Wael A. H. Hegazy   +10 more
doaj   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, Volume 40, Issue 10, Page 5973-5987, October 2026.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Sulforaphane induces glioprotection after LPS challenge

, 2022
Sulforaphane is a natural compound that presents anti-inflammatory and antioxidant properties, including in the central nervous system (CNS). Astroglial cells are involved in several functions to maintain brain homeostasis, actively participating in the ...
Goncalves, Carlos Alberto Saraiva, Bobermin, Larissa Daniele, Belló-Klein, Adriane, Wyse, Angela Terezinha de Souza, Weber, Fernanda Becker, Santos, Tiago Marcon dos, Quincozes-Santos, André   +6 more
core   +1 more source

Commercial Oat‐Based Cosmetic Ingredients Promote Antioxidant Capacity and Reduce Inflammatory Markers in Skin Cellular Stress Models: An Insight Into Molecular Mechanisms In Vitro

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background Dermal products containing oat (Avena sativa L.) have a wide range of benefits on human skin and are commonly incorporated into skincare products. Aims The study focused on evaluating the antioxidant, cytoprotective, and anti‐inflammatory potential of three commercial sources of oat bioactive compounds—Aurafirm P, AvenaPLex, and Oat
Jiří Hanyk, Alena Rajnochová Svobodová, Zdeněk Dostál, Bohumil Zálešák, Jitka Vostálová   +4 more
wiley   +1 more source

The qRT-PCR genes related sulforaphane metabolism and their primers.

, 2019
The qRT-PCR genes related sulforaphane metabolism and their primers.
Honghao Lv (800307), Mu Zhuang (537090), Yangyong Zhang (537091), Zhansheng Li (537088), Limei Yang (223781), Yumei Liu (286628), Lingyun Li (142918), Zhiyuan Fang (537089)   +7 more
core   +1 more source