Results 11 to 20 of about 20,368 (201)
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2020 Heparan sulfate (HS) is a glycosaminoglycan found mainly in its protein-conjugated form at the cell surface and the extracellular matrix. Its high sulfation degree mediates functional interactions with positively charged amino acids in proteins.
Felipe C. O. B. Teixeira +11 more
doaj +1 more source
Computational Analysis of Chemical Space of Natural Compounds Interacting with Sulfotransferases
Molecules, 2021 The aim of this study was to investigate the chemical space and interactions of natural compounds with sulfotransferases (SULTs) using ligand- and structure-based in silico methods.
Iglika Lessigiarska +10 more
doaj +1 more source
Angewandte Chemie, EarlyView.A glycan having a hydrazide tag enables chemoenzymatic synthesis of HS oligosaccharides. The hydrazide can, under mild acidic conditions, react with an aldehyde‐containing resin to give an immobilized hydrazone that is stable under neutral conditions, allowing washing. The product can be released by transiminolysis using aqueous hydroxylamine to give a
Francesco Palmieri +4 more
wiley +2 more sources
Structure of sulfatides biosynthesized in vitro
Journal of Lipid Research, 1971 Starting from galactose-14C-labeled phrenosine and 3′-phosphoadenosine-5′-phosphosulfate, radioactive sulfatides have been obtained in vitro with a biosynthetic system similar to the one described by McKhann and Ho (Ref. 6).
PIERRE STOFFYN +2 more
doaj +1 more source
Paralytic Shellfish Toxins (PST)-Transforming Enzymes: A Review
Toxins, 2020 Paralytic shellfish toxins (PSTs) are a group of toxins that cause paralytic shellfish poisoning through blockage of voltage-gated sodium channels.
Mariana I. C. Raposo +3 more
doaj +1 more source
A Unique Sulfotransferase-Involving Strigolactone Biosynthetic Route in Sorghum
Frontiers in Plant Science, 2021 LOW GERMINATION STIMULANT 1 (LGS1) plays an important role in strigolactones (SLs) biosynthesis and Striga resistance in sorghum, but the catalytic function remains unclear.
Sheng Wu, Yanran Li
doaj +1 more source
Molecules, 2018 Heparan sulfate 3-O-sulfotransferases (HS3STs) catalyze the maturation step of heparan sulfate (HS) 3-O-sulfation. This modification is relatively rare.
Charles Hellec +4 more
doaj +1 more source
Sulfotransferases and Sulfatases in Mycobacteria [PDF]
Chemistry & Biology, 2002 Analysis of the genomes of M. tuberculosis, M. leprae, M. smegmatis, and M. avium has revealed a large family of genes homologous to known sulfotransferases. Despite reports detailing a suite of sulfated glycolipids in many mycobacteria, a corresponding family of sulfotransferase genes remains uncharacterized.
Mougous, Joseph D +4 more
openaire +2 more sources
Structure and Function of Sulfotransferases [PDF]
Archives of Biochemistry and Biophysics, 2001 Sulfotransferases (STs) catalyze the transfer reaction of the sulfate group from the ubiquitous donor 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor group of numerous substrates. This reaction, often referred to as sulfuryl transfer, sulfation, or sulfonation, is widely observed from bacteria to humans and plays a key role in various ...
Negishi, Masahiko +6 more
openaire +3 more sources