Results 61 to 70 of about 21,198 (194)

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Two different sulfotransferases modify sugars of the N-linked tetrasaccharide decorating Halobacterium salinarum glycoproteins

mBio
Despite providing the first example of archaeal N-glycosylation almost 50 years ago, detailed insight into the pathway used by Halobacterium salinarum to assemble and attach an N-linked tetrasaccharide decorating glycoproteins in this haloarchaea has ...
Marianna Zaretsky, Zlata Vershinin, Lihi Erez, Iris Grossman-Haham, Jerry Eichler   +4 more
doaj   +1 more source

In Vitro Sulfotransferase Activity of NoeE, a Nodulation Protein of Rhizobium sp. NGR234

Molecular Plant-Microbe Interactions, 1998
Soil bacteria of the genera Azorhizobium, Bradyrhizobium, and Rhizobium liberate morphogenetic lipochitin-oligosac-charides (Nod factors) into legume rhizospheres.
D. Quesada-Vincens, M. Hanin, W. J. Broughton, S. Jabbouri   +3 more
doaj   +1 more source

Genome‐wide prediction of cloned disease resistance homologues across the Oryza genus

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract The wild relatives of rice (Oryza sativa L.) represent reservoirs of genetic diversity and potential sources of novel pest and disease resistance. The recent availability of high‐quality Oryza genome assemblies has enabled greater exploration of this diversity across the genus.
Sabrina Morrison, Jacqueline Batley, Ian Paul Navea, Van Schepler‐Luu, Robert J. Henry   +4 more
wiley   +1 more source

GlcNAc6ST2/CHST4 Is Essential for the Synthesis of R-10G-Reactive Keratan Sulfate/Sulfated N-Acetyllactosamine Oligosaccharides in Mouse Pleural Mesothelium

Molecules
We recently showed that 6-sulfo sialyl N-acetyllactosamine (LacNAc) in O-linked glycans recognized by the CL40 antibody is abundant in the pleural mesothelium under physiological conditions and that these glycans undergo complementary synthesis by ...
Yoshiko Takeda-Uchimura, Midori Ikezaki, Tomoya O. Akama, Yoshito Ihara, Fabrice Allain, Kazuchika Nishitsuji, Kenji Uchimura   +6 more
doaj   +1 more source

Effects of ethinylestradiol on enzymes catalyzing bile acid conjugation and sulfation

Journal of Lipid Research, 1980
Administration of large doses of estrogens has been shown to result in decreased conjugation and increased sulfation of bile acids as well as cholestasis. There have been no previous studies on the effects of low doses of estrogens on these parameters of
R B Kirkpatrick, P G Killenberg
doaj   +1 more source

Multiplexed Nanosensors for Real‐Time Monitoring of VOC‐Mediated Signalling Response in Plants

Plant, Cell &Environment, Volume 49, Issue 12, Page 9907-9931, December 2026.
ABSTRACT To enhance crop performance, intercropping strategies leverage volatile organic compound (VOC)‐driven interactions with companion plants that constitutively emit VOCs. Despite the agricultural importance, the mechanisms and kinetics of VOC‐mediated sensory transduction in receiver plants eavesdropping on neighbouring non‐kin emitters remain ...
Mervin Chun‐Yi Ang, Jolly Madathiparambil Saju, Sayyid Mohaideen, Niha Dhar, Sarangapani Sreelatha, Sayuj Koyyappurath, Thomas K. Porter, Gabriel Sánchez‐Velázquez, Vaishnavi Reddy Amarr, Song Wang, Duc Thinh Khong, Suh In Loh, Michael S. Strano, Sarojam Rajani   +13 more
wiley   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1338-1347, November 2026.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1368-1378, November 2026.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

Identification and Characterization of Tyrosylprotein Sulfotransferase from Human Saliva

International Journal of Biological Sciences, 2005
Tyrosylprotein sulfotransferase (TPST), the enzyme responsible for the sulfation of tyrosine residues, has been identified and characterized in submandibular salivary glands previously (William et al. Arch Biochem Biophys 338: 90-96).
doaj