Results 71 to 80 of about 20,368 (201)

Identification and Characterization of Tyrosylprotein Sulfotransferase from Human Saliva

International Journal of Biological Sciences, 2005
Tyrosylprotein sulfotransferase (TPST), the enzyme responsible for the sulfation of tyrosine residues, has been identified and characterized in submandibular salivary glands previously (William et al. Arch Biochem Biophys 338: 90-96).
doaj  

Galactosylceramide containing omega-amino-fatty acids: preparation, characterization, and sulfotransferase acceptor.

Journal of Lipid Research, 1992
For preparation of an affinity ligand, an N-fatty acyl moiety of galactosylceramide (GalCer) was chemically replaced with omega-amino-fatty acid including amino-n-hexanoic acid or amino-n-dodecanoic acid to obtain omega-aminoGalCer.
K Kamio, S Gasa, A Makita
doaj   +1 more source

Keratan Sulfate: An Electroconductive Glycosaminoglycan at the Interface of Sensory Perception and Neural Signaling

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley   +1 more source

Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak, Rachael Moorin, Jeff Hughes, Karl Gruber, David Youens   +4 more
wiley   +1 more source

Insights into the N-sulfation mechanism: molecular dynamics simulations of the N-sulfotransferase domain of NDST1 and mutants.

PLoS ONE, 2013
Sulfation patterns along glycosaminoglycan (GAG) chains dictate their functional role. The N-deacetylase N-sulfotransferase family (NDST) catalyzes the initial downstream modification of heparan sulfate and heparin chains by removing acetyl groups from ...
Tarsis F Gesteira, Laércio Pol-Fachin, Vivien Jane Coulson-Thomas, Marcelo A Lima, Hugo Verli, Helena B Nader   +5 more
doaj   +1 more source

Tinospora cordifolia consumption ameliorates changes in kidney chondroitin sulphate/dermatan sulphate in diabetic rats

Journal of Nutritional Science, 2012
Diabetes is known to alter kidney extracellular matrix (ECM) components. Chondroitin sulphate (CS)/dermatan sulphate (DS), an ECM component, which plays an essential role in kidney is altered during diabetes.
Darukeshwara Joladarashi, Nandini D. Chilkunda, Paramahans V. Salimath   +2 more
doaj   +1 more source

Encounters With Traditional Medicine and Further Multidisciplinary and International Cooperation

Traditional &Kampo Medicine, Volume 13, Issue 2, August 2026.
ABSTRACT Background The integration of traditional medicine (TM) into modern healthcare has gained global momentum. Following the inclusion of TM in the 11th revision of the International Classification of Diseases, multidisciplinary and international cooperation has become increasingly essential.
Kokoro Ichihara, Ryota Sakoda, Yuto Matsuura, Hong‐Wook Choi, Toshiaki Makino, Tomoko Suzuki, Shin Takayama   +6 more
wiley   +1 more source

A sulfotransferase dosage-dependently regulates mouthpart polyphenism in the nematode Pristionchus pacificus

Nature Communications, 2018
Certain genotypes define developmental plasticity and discrete morphologies, but a mechanism as to how this arises is unclear. Here, the authors show that dosage-specific sulfotransferase (SEUD-1) expression specifies which mouthparts are expressed in ...
Linh T. Bui, Nicholas A. Ivers, Erik J. Ragsdale   +2 more
doaj   +1 more source

Pharmacokinetic Drug–Drug Interactions of Imlunestrant in Healthy Female Participants of Nonchildbearing Potential

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Imlunestrant is a next‐generation, oral, selective estrogen receptor degrader approved for treating adults with estrogen receptor‐positive, human epidermal growth factor receptor 2‐negative, ESR1‐mutated advanced/metastatic breast cancer. Imlunestrant is metabolized partly by cytochrome P450 (CYP)3A4 oxidation and conjugation with glucuronic ...
Amita Datta‐Mannan, Elaine Shanks, Eunice Yuen, Vivian Rodriguez Cruz, Xuejing Aimee Wang, Stephen David Hall   +5 more
wiley   +1 more source

Garadacimab for the long‐term prophylaxis of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 8, Page e1034-e1044, August 2026.
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl   +5 more
wiley   +1 more source