Results 241 to 250 of about 9,711 (311)

A comprehensive review on magnetic manganese as catalysts in organic synthesis. [PDF]

RSC Adv
Kazemi M, Ali R, Jain V, Ballal S, Abosaoda MK, Singh A, Krithiga T, Joshi KK, Javahershenas R.   +8 more
europepmc   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

From perfluoroalkyl aryl sulfoxides to ortho thioethers. [PDF]

Beilstein J Org Chem
Li Y, Dagousset G, Dagousset G, Magnier E, Pégot B.   +4 more
europepmc   +1 more source

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

Phenothiazine Sulfoxides as Active Photocatalysts for the Synthesis of γ-Lactones. [PDF]

J Am Chem Soc
Hölter N, Rendel NH, Spierling L, Kwiatkowski A, Kleinmans R, Daniliuc CG, Wenger OS, Glorius F.   +7 more
europepmc   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Sulfilimines: An Underexplored Bioisostere for Drug Design? [PDF]

J Med Chem
Arvidsson PI.
europepmc   +1 more source

Stereoselective Synthesis of Chiral C₂-Symmetric 1,3- and 1,5-Bis-Sulfoxides Guided by the Horeau Principle: Understanding the Influence of the Carbon Chain Nature in Its Ability for Metal Coordination. [PDF]

J Org Chem
Moreno-Rodríguez N, Prieto LA, Valdivia V, Recio R, Fernández I.   +4 more
europepmc   +1 more source

Enantioselectivity in Vanadium-Dependent Haloperoxidases of Different Marine Sources for Sulfide Oxidation to Sulfoxides. [PDF]

Mar Drugs
Zhang YH, Zou YT, Zeng YY, Liu L, Chen BS.   +4 more
europepmc   +1 more source