Results 1 to 10 of about 12,154 (204)

Discovery of novel sulphonamide hybrids that inhibit LSD1 against bladder cancer cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Aim:A series of sulphonamide hybrids were designed, synthesised, and identified as potential lysine-specific demethylase 1 (LSD1) inhibitors.Materials and methods: Bladder cancer cell lines were cultured to evaluate the antiproliferative activity ...
Jia Liu, Xingwang Zhu, Liu Yu, Minghuan Mao   +3 more
doaj   +2 more sources

Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancer

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A series of tertiary sulphonamide derivatives were synthesised and evaluated for their antiproliferative activity against liver cancer cell lines (SNU-475, HepG-2, and Bel-7402).
Lijuan Ding, Nanya Wang
exaly   +2 more sources

Evaluation of sulphonamide derivatives acting as inhibitors of human carbonic anhydrase isoforms I, II and Mycobacterium tuberculosisβ-class enzyme Rv3273

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
A series of novel sulphonamide derivatives was obtained from sulphanilamide which was N4-alkylated with ethyl bromoacetate followed by reaction with hydrazine hydrate. The hydrazide obtained was further reacted with various aromatic aldehydes.
Mrunmayee P Toraskar, Silvia Bua, Claudiu T Supuran   +2 more
exaly   +2 more sources

Antimicrobial Resistance Among Selected Zoonotic Bacteria: A Case Study of Tortoises and Birds at the Uganda Wildlife Conservation Education Centre. [PDF]

Vet Med Sci
This study investigated antimicrobial resistance in birds and tortoises at the Uganda Wildlife Conservation Education Centre. Escherichia coli predominated in birds, whereas Salmonella enteritidis predominated in tortoises with resistance to sulphonamides detected.
Namara DD, Ssajjakambwe P, Nakabuye SR, Katabazi VA, Sente C.   +4 more
europepmc   +2 more sources

Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Sulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, 13C NMR, 1H NMR, LC-MS and elemental analysis.
Zeid A. Al-Othman, Cüneyt Türkeş, Mesut Işık   +2 more
exaly   +2 more sources

Diverse role, structural trends, and applications of fluorinated sulphonamide compounds in agrochemical and pharmaceutical fields [PDF]

Heliyon
Our knowledge of fluorine's unique and complex properties has significantly increased over the past 20 years. Consequently, more sophisticated and innovative techniques have emerged to incorporate this feature into the design of potential drug candidates.
Shankar B. Chaudhari, Anupam Kumar, Viraj H. Mankar, Shaibal Banerjee, Deepak Kumar, Nabisab Mujawar Mubarak, Mohammad Hadi Dehghani   +6 more
doaj   +2 more sources

Antimicrobial resistance in Escherichia coli from Swedish piglets with diarrhoea and associations with potential risk factors [PDF]

Acta Veterinaria Scandinavica
Background Antibiotic treatments of diarrhoea in suckling piglets and in pigs after weaning are common worldwide and contribute to antimicrobial resistance (AMR) in Escherichia coli from pigs.
Estelle Ågren, Annette Backhans, Maria Lindberg, Marie Sjölund, Björn Bengtsson, Arianna Comin   +5 more
doaj   +2 more sources

Resistance evolution under potentiated sulphonamide pressure in Escherichia coli [PDF]

Frontiers in Veterinary Science
IntroductionAntimicrobial resistance (AMR) poses an escalating global health threat. Potentiated sulphonamides are widely used in both veterinary and human medicine.
Ádám Kerek, Ádám Kerek, Bence Török, Ábel Szabó, Levente Laczkó, Levente Laczkó, Levente Laczkó, Gábor Kardos, Gábor Kardos, Gábor Kardos, Gábor Kardos, Krisztián Bányai, Krisztián Bányai, Krisztián Bányai, Krisztián Bányai, Eszter Kaszab, Eszter Kaszab, Eszter Kaszab, Eszter Kaszab, Krisztina Bali, Krisztina Bali, Ákos Jerzsele, Ákos Jerzsele   +22 more
doaj   +2 more sources

The gram-negative bacterium Escherichia coli as a model for testing the effect of carbonic anhydrase inhibition on bacterial growth

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Carbonic anhydrases, catalysing the reversible CO2 hydration reaction, contribute in all living organisms to the maintenance of stable metabolic functions depending on intracellular concentrations of carbon dioxide, bicarbonate, and protons.
Viviana De Luca, Vincenzo Carginale, Claudiu T. Supuran, Clemente Capasso   +3 more
doaj   +1 more source

MICROBIOLOGICAL EVALUATION AND MYCOTOXIN RESIDUES IN SOME FROZEN CAMEL'S MEAT PRODUCTS [PDF]

Veterinary Medical Journal - Giza, 2004
A total of 120 birds (thirty from each of: ostrich “Struthio camelus”, ducks “Anas plathyrhyn chus”. Geese “Anser domesticus” and turkeys “Meleagris gallopavonis”) were collected from different farms in Egypt and freshly slaughtered except ostrich ...
JEHAN OUF
doaj   +1 more source