Results 31 to 40 of about 12,154 (204)

Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The Carbonic anhydrase isoforms IX and XII play a significant role in regulating the intracellular and extracellular pH in hypoxic tumours abetting the metastasis of solid tumours.
Shaik Mahammad Ghouse, Kavyaraj Bahatam, Andrea Angeli, Gaurav Pawar, Krishna Kartheek Chinchilli, Venkata Madhavi Yaddanapudi, Arifuddin Mohammed, Claudiu T. Supuran, Srinivas Nanduri   +8 more
doaj   +1 more source

Synthesis and human carbonic anhydrase I, II, VA, and XII inhibition with novel amino acid–sulphonamide conjugates

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of amino acid–sulphonamide conjugates was prepared through benzotriazole mediated coupling reactions and characterised by 1H-NMR, 13C-NMR, MS, and FTIR spectroscopic techniques as well as elemental analysis.
Hasan Küçükbay, Nesrin Buğday, F. Zehra Küçükbay, Andrea Ageli, Gianluca Bartolucci, Claudiu T. Supuran   +5 more
doaj   +1 more source

Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoni

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Schistosoma mansoni is an intestinal parasite with one β-class carbonic anhydrase, SmaBCA. We report the sequence enhancing, production, catalytic activity, and inhibition results of the recombinant SmaBCA. It showed significant catalytic activity on CO2
Susanna Haapanen, Andrea Angeli, Martti Tolvanen, Reza Zolfaghari Emameh, Claudiu T. Supuran, Seppo Parkkila   +5 more
doaj   +1 more source

Iodine-mediated one-pot intramolecular decarboxylation domino reaction for accessing functionalised 2-(1,3,4-oxadiazol-2-yl)anilines with carbonic anhydrase inhibitory action

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
A practical and transition metal-free one-pot domino synthesis of diversified (1,3,4-oxadiazol-2-yl)anilines has been developed employing isatins and hydrazides as the starting materials, in the presence of molecular iodine. The prominent feature of this
Srinivas Angapelly, P. V. Sri Ramya, Rohini Sodhi, Andrea Angeli, Krishnan Rangan, Narayana Nagesh, Claudiu T. Supuran, Mohammed Arifuddin   +7 more
doaj   +1 more source

Novel sulphonamides incorporating triazene moieties show powerful carbonic anhydrase I and II inhibitory properties

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of compounds incorporating 3-(3-(2/3/4-substituted phenyl)triaz-1-en-1-yl) benzenesulfonamide moieties were synthesised and their chemical structure was confirmed by physico-chemical methods.
Sinan Bilginer, Baris Gonder, Halise Inci Gul, Ruya Kaya, Ilhami Gulcin, Baris Anil, Claudiu T. Supuran   +6 more
doaj   +1 more source

EFFECTS OF INHIBITORS OF SULFANILAMIDE ACETYLATION ON SULPHONAMIDE BLOOD CONCENTRATIONS

, 1955
The effect of inhibitors of sulphanilamide acetylation on free and total sulphonamide blood levels has been investigated. p-Aminosalicylic acid hydrazide, administered to rabbits in combination with sulphanilamide, produced a twofold increase in the ...
Willard Johnson
core   +1 more source

Sulphonamide Resistance in Neisseria meningitidis and Commensal Neisseria Species

, 2003
Extensive use of the sulphonamide drugs against the bacterium Neisseria meningitidis has resulted in drug resistance development. Sulphonamide resistance in N.
Qvarnström, Yvonne
core   +2 more sources

Synthesis and complexation of some azo-sulphonamide derivatives

, 2006
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11884, Egypt E-mail: hammad@yahoo.com Chemistry Department, Faculty of Science, AI-Azhar University, at Assiut, Assiut, 71524, Egypt Manuscript received 11 October 2004 ...
Hamdy A. Hammad, Abu Bakr A. A. M. EI-Adasy, Ahmed z. Sayed   +2 more
core   +1 more source

Sulphonamide inhibition studies of the β-carbonic anhydrase from the bacterial pathogen Clostridium perfringens

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The β-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacterium Clostridium perfringens (CpeCA) was recently characterised kinetically and for its anion inhibition profile. In the search of effective CpeCA inhibitors, possibly useful to inhibit
Daniela Vullo, R. Siva Sai Kumar, Andrea Scozzafava, James G. Ferry, Claudiu T. Supuran   +4 more
doaj   +1 more source

Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Selective inhibition with sulphonamides of carbonic anhydrase (CA) IX reduces cell proliferation and induces apoptosis in human cancer cells. The effect on CA IX expression of seven previously synthesised sulphonamide inhibitors, with high affinity for ...
Ismail Koyuncu, Ataman Gonel, Abdurrahim Kocyigit, Ebru Temiz, Mustafa Durgun, Claudiu T. Supuran   +5 more
doaj   +1 more source